A concise method for the preparation of deuterium-labeled cortisone: Synthesis of [6,7-2H]cortisone

Steroids

Volumn 70, Issue 11, 2005, Pages 763-769

  Sulima, Agnieszka ^a   Prisinzano, Thomas E ^a,e   Spande, Thomas ^a   Deschamps, Jeffrey R ^b   Whittaker, Noel ^c   Hochberg, Zeev ^d   Jacobson, Arthur E ^a   Rice, Kenner C ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NAVAL RESEARCH LABORATORY   (United States)

^c University of Maryland   (United States)

^d MEYER CHILDREN S HOSPITAL   (Israel)

^e UNIVERSITY OF IOWA   (United States)

Author keywords

11 HSD; 6,7 2H Cortisone; Cortisol; Cortisone; Deuterium label

Indexed keywords

17ALPHA,20:20,21 BISMETHYLENEDIOXYPREGNA 4,6 DIENE 3,11 DIONE; 17ALPHA,21 DIHYDROXYPREGNA 4,6 DIENE 3,11,20 TRION 21 ACETATE; 17ALPHA,21 DIHYDROXYPREGNA 4,6 DIENE 3,11,20 TRIONE; [6,7 2 H 2] 17ALPHA,20:20,21 BISMETHYLENEDIOXYPREGN 4 ENE 3,11 DIONE; [6,7 2 H 2] 17ALPHA,21 DIHYDROXYPREGN 4 ENE 3,11,20 TRIONE; [6,7 H 2] CORTISONE; ACETIC ACID DERIVATIVE; ALKADIENE; CORTISONE; CORTISONE ACETATE; CORTISONE DERIVATIVE; DEUTERIUM; DIENONE ACETATE; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; CATALYST; DRUG SYNTHESIS; HORMONE METABOLISM; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROLYSIS; LABELING INDEX;

CORTISONE; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; ISOTOPE LABELING; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR;

EID: 23844539772     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2005.04.006     Document Type: Article

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