Cortisol, 11β-hydroxysteroid dehydrogenase type 1 and central obesity

Trends in Endocrinology and Metabolism

Volumn 13, Issue 3, 2002, Pages 94-96

  Stewart, Paul M ^a   Tomlinson, Jeremy W ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 11BETA HYDROXYSTEROID DEHYDROGENASE INHIBITOR; ENZYME INHIBITOR; GLYCYRRHETINIC ACID; HYDROCORTISONE; ISOENZYME; UNCLASSIFIED DRUG; HYDROXYSTEROID DEHYDROGENASE;

ADIPOCYTE; BODY FAT; CELL DIFFERENTIATION; CUSHING SYNDROME; DISEASE ASSOCIATION; DRUG EFFECT; HUMAN; HYDROCORTISONE BLOOD LEVEL; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; STROMA CELL; TREATMENT PLANNING; ADIPOSE TISSUE; ARTICLE; CYTOLOGY; ENZYMOLOGY; METABOLISM;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ADIPOCYTES; ADIPOSE TISSUE; CUSHING SYNDROME; HUMANS; HYDROCORTISONE; HYDROXYSTEROID DEHYDROGENASES; OBESITY; STROMAL CELLS;

EID: 0036547966     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(02)00566-0     Document Type: Review

References (10)

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2. White, P.C. et al. (1997) 11β-hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocr. Rev. 18, 135-136
3. Stewart, P.M. and Krozowski, Z.S. (1999) 11β-hydroxysteroid dehydrogenase. Vitam. Horm. 57, 249-324
4. Bujalska, I.J. et al. (1997) Does central obesity reflect 'Cushing's disease of the omentum?' Lancet 349, 1210-1213
5. Hauner, H. et al. (1989) Promoting effects of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium. J. Clin. Invest. 84, 1663-1670
6. Bujalska, I.J. et al. (1999) Differentiation of human adipose stromal cells: the roles of glucocorticoids and 11β-hydroxysteroid dehydrogenase. Endocrinology 140, 3188-3196
7. Masuzaki, H. et al. (2001) A transgenic model of visceral obesity and the metabolic syndrome. Science 294, 2166-2170
8. Stewart, P.M. et al. (1999) Cortisol metabolism in human obesity: impaired cortisone-cortisol conversion in subjects with central obesity. J. Clin. Endocrinol. Metab. 84, 1022-1027
9. Rask, E. et al. (2001) Tissue-specific dysregulation of cortisol metabolism in human obesity. J. Clin. Endocrinol. Metab. 86, 1418-1421
10. Rabbitt, E. et al. (2002) Prereceptor regulation of glucocorticoid action by 11β-hydroxysteroid dehydrogenase: a novel determinant of cell proliferation. FASEB J 16, 36-44