A simple approach to azirines containing an aldehyde functionality and their stabilization as palladium(II) complexes

Tetrahedron Letters

Volumn 46, Issue 38, 2005, Pages 6575-6578

  Brahma, Sulagna ^a   Ray, Jayanta K ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Azirines; Bromo chloro aldehyde; Palladium complex; Vinyl nitrene

Indexed keywords

ALDEHYDE DERIVATIVE; AZIRINE DERIVATIVE; BROMINE DERIVATIVE; CHLORINE DERIVATIVE; PALLADIUM COMPLEX;

ARTICLE; DRUG STABILITY; DRUG SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; ROOM TEMPERATURE; THIN LAYER CHROMATOGRAPHY;

EID: 23844504377     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.07.086     Document Type: Article

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19. 3, these two peaks were shifted upfield (10.10 ppm to 9.97 ppm and 6.94 ppm to 5.76 ppm), which clearly supported the formation of azido-aldehyde 6a. Due to the formation of NaCl, we could not take further clear NMR spectra. So after work-up, followed by separation using preparative TLC, azirine 7a (60%) and isoxazole 8a (8%) were obtained.
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