Recent advances in our understanding of intercalated cells

Current Opinion in Nephrology and Hypertension

Volumn 14, Issue 5, 2005, Pages 480-484

  Wall, Susan M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Ammonium; Bicarbonate; Chloride; Intercalated cells; Net Acid secretion

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ALDOSTERONE; AMMONIA; AQUAPORIN 2; BICARBONATE; CARBONATE DEHYDRATASE II; CHLORIDE; HYDROGEN; PENDRIN; VASOPRESSIN;

ACID BASE BALANCE; ACID SECRETION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BLOOD PRESSURE REGULATION; CELL FUNCTION; CELLULAR DISTRIBUTION; CHLORIDE TRANSPORT; CONTROLLED STUDY; GENE DISRUPTION; INTERCALATED CELL; KIDNEY CELL; KIDNEY COLLECTING TUBULE; KIDNEY DISTAL TUBULE; KNOCKOUT MOUSE; METABOLIC ALKALOSIS; MOUSE; NONHUMAN; ONTOGENY; PENDRED SYNDROME; PRIORITY JOURNAL; REVIEW; SODIUM RESTRICTION;

EID: 23844498531     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mnh.0000168390.04520.06     Document Type: Review

References (48)

1. +-ATPase. Proc Natl Acad Sci U S A 1989; 86:5429-5433.
2. Kim J, Kim Y-H, Cha J-H, et al. Intercalated cell subtypes in connecting tubule and cortical collecting duct of rat and mouse. J Am Soc Nephrol 1999; 10:1-12.
3. Schuster VL. Function and regulation of collecting duct intercalated cells. Annu Rev Physiol 1993; 55:267-288.
4. Teng-ummnuay P, Verlander JW, Yuan W, et al. Identification of distinct subpopulations of intercalated cells in the mouse collecting duct. J Am Soc Nephrol 1996; 7:260-274.
5. Wall SM, Hassell KA, Royaux IE, et al. Localization of pendrin in mouse kidney. Am J Physiol Renal Physiol 2003; 284:F229-F241.
6. Brown D, Hirsch S, Gluck S. Localization of a proton-pumping ATPase in rat kidney. J Clin Invest 1988; 82:2114-2126.
7. Emmons C. New subtypes of rabbit CCD intercalated cells as functionally defined by anion exchange and H+-ATPase activity [abstract]. J Am Soc Nephrol 1993; 4:838.
8. Weiner ID, Hamm LL. Regulation of intracellular pH in the rabbit cortical collecting tubule. J Clin Invest 1990; 85:274-281.
9. Emmons C, Kurtz I. Functional characterization of three intercalated cell subtypes in the rabbit outer cortical collecting duct. J Clin Invest 1994; 93:417-423.
10. Blomqvist SR, Vidarsson H, Fitzgerald S, et al. Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1. J Clin Invest 2004; 113:1560-1570. This study provides novel observations regarding the mechanism of the differentiation of precursor cells into mature intercalated cell subtypes and principal cells.
11. Schwartz GJ, Tsuruoka S, Vijayakumar S, et al. Acid incubation reverses the polarity of intercalated cell transporters, an effect mediated by hensin. J Clin Invest 2002; 109:89-99.
12. Al-Awqati Q, Vijayakumar S, Takito J. Terminal differentiation of epithelia from trophectoderm to the intercalated cell: the role of hensin. J Am Soc Nephrol 2003; 14:S16-S21.
13. Schlatter E, Greger R, Schafer JA. Principal cells of cortical collecting ducts of the rat are not a route of transepithelial Cl transport. Pflugers Arch 1990; 417:317-323.
14. Royaux IE, Wall SM, Karniski LP, et al. Pendrin, encoded by the pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion. Proc Natl Acad Sci U S A 2001; 98:4221-4226.
15. Kim Y-H, Kwon T-H, Frische S, et al. Immunocytochemical localization of pendrin in intercalated cell subtypes in rat and mouse kidney. Am J Physiol Renal Physiol 2002; 283:F744-F754.
16. Scott DA, Wang R, Kreman TM, et al. The Pendred syndrome gene encodes a chloride-iodide transport protein. Nat Genet 1999; 21:440-443.
17. Emmons C. Halide transport patterns of apical anion exchange in rabbit cortical collecting duct intercalated cells. Am J Physiol Renal Physiol 1996; 271:F799-F805.
18. 3 exchanger in the kidney cortex. Am J Physiol Renal Physiol 2001; 280:F356-F364.
19. - conservation. Hypertension 2004; 44:1-6. This study demonstrated the role of pendrin in renal chloride conservations and hence its role in the maintenance of vascular volume.
20. Frische S, Kwon T-H, Frokiaer J, et al. Regulated expression of pendrin in rat kidney in response to chronic NH4Cl or NaHCOS loading. Am J Physiol Renal Physiol 2003; 284:F584-F593.
21. Verlander JW, Hassell KA, Royaux IE, et al. Deoxycorticosterone upregulates Pds (Slc26a4) in mouse kidney: role of pendrin in mineralocorticoid-induced hypertension. Hypertension 2003; 42:356-362. This study demonstrated a role of pendrin in blood pressure regulates.
22. Everett LA, Glaser B, Beck JC, et al. Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS). Nat Genet 1997; 17:411-422.
23. Pendred V. Deaf-mutism and goitre. Lancet 1896; 2:532.
24. - /anion exchanger pendrin in mouse kidney by acid-base status. Kidney Int 2002; 62:2109-2117.
25. Quentin F, Chambrey R, Trinh-Trang-Tan MM, et al. The Cl /HCO3 exchanger pendrin in the rat kidney is regulated in response to chronic alterations in chloride balance. Am J Physiol Renal Physiol 2004; 287:F1179-F1188. This study demonstrated that pendrin expression is regulated through aldosterone- independent mechanism(s).
26. Kwon T-H, Pushkin A, Abuladze N, et al. Immunoelectron microscopic localization of NBC3 sodium-bicarbonate cotransporter in rat kidney. Am J Physiol Renal Physiol 2000; 278:F327-F336.
27. Ko SBH, Luo X, Hager H, et al. AE4 is a DIDS-sensitive Cl /HCO3 exchanger in the basolateral membrane of the renal CCD and the SMG duct. Am J Physiol Cell Physiol 2002; 283:C1206-C1218.
28. + extrusion in mouse cortical collecting duct (CCD) intercalated cells [abstract]. J Am Soc Nephrol 1997; 8:5A.
29. Kovacikova J, Paunescu T, Bacic D, et al. B-Intercalated cell function is deficient in mice lacking the B1 subunit of the H+-ATPase [abstract]. J Am Soc Nephrol 2004; 15:73A.
30. Kim Y-H, Verlander JW, Matthews SW, et al. H+-ATPase expression is markedly reduced in type B and non-A, non-B intercalated cells of Pds (-/-) mice [abstract]. J Am Soc Nephrol 2004; 15:70A.
31. Tsuganezawa H, Kobayashi K, Iyori M, et al. A new member of the HCO3 transporter superfamily is an apical anion exchanger of beta-intercalated cells in the kidney. J Biol Chem 2001; 276:8180-8189.
32. Madsen KM, Tisher CC. Structural-functional relationships along the distal nephron. Am J Physiol Renal Physiol 1986; 250:F1-F15.
33. Tsuruoka S, Schwartz GJ. Metabolic acidosis stimulates H secretion in the rabbit outer medullary collecting duct (inner stripe) of the kidney. J Clin Invest 1997; 99:1420-1431.
34. Weiner ID, Frank AE, Wingo CS. Apical proton secretion by the inner stripe of the outer medullary collecting duct. Am J Physiol Renal Physiol 1999; 276:F606-F613.
35. Stone DK, Seldin DW, Kokko JP, Jacobson HR. Anion dependence of rabbit medullary collecting duct acidification. J Clin Invest 1983; 71:1505-1508.
36. 3 exchanger (Slc4a1) [abstract]. J Am Soc Nephrol 2004; 15:70A.
37. Stone DK, Seldin DW, Kokko JP, Jacobson HR. Mineralocorticoid modulation of rabbit medullary collecting duct acidification. J Clin Invest 1983; 72:77-83.
38. Winter C, Schulz N, Giebisch G, et al. Nongenomic stimulation of vacuolar H+-ATPases in intercalated renal tubule cells by aldosterone. Proc Natl Acad Sci U S A 2004; 101:2636-2641. This study demonstrated the importance of the nongenomic regulation of the H+-ATPase.
39. Verlander JW, Madsen KM, Cannon JK, Tisher CC. Activation of acid-secreting intercalated cells in rabbit collecting duct with ammonium chloride loading. Am J Physiol Renal Physiol 1994; 266:F633-F645.
40. Bastani B, Purcell H, Hemken P, et al. Expression and distribution of renal vacuolar proton-translocating adenosine triphosphatase in response to chronic acid and alkali loads in the rat. J Clin Invest 1991; 88:126-136.
41. Wall SM, Fischer MP, Glapion DM, De La Calzada M. Ang II reduces net acid secretion in rat outer medullary collecting duct. Am J Physiol Renal Physiol 2003; 285:F930-F937.
42. Valles P, Wysocki J, Salabat MR, et al. Angiotensin II increases H+-ATPase B1 subunit expression in medullary collecting ducts. Hypertension 2005; 45:818-823.
43. - secretion in rat outer medullary collecting duct. Am J Physiol Renal Physiol 2001; 280:F913-F921.
44. + in rat outer medullary collecting duct. J Am Soc Nephrol 2002; 13:827-835.
45. Barone S, Amlal H, Xu J, et al. Differential regulation of basolateral Cl / HCO3 exchangers Slc26a7 and AE1 in kidney outer medullary collecting duct. J Am Soc Nephrol 2004; 15:2002-2011.
46. Wall SM. Mechanisms of NH4+ and NH3 transport during hypokalemia. Acta Physiol Scand 2003; 179:325-330.
47. Nakhoul NL, Hamm LL. Non-erythroid Rh glycoproteins: a putative new family of mammalian ammonium transporters. Pflugers Arch 2004; 447:807-812.
48. Weiner ID. The Rh gene family and renal ammonium transport. Curr Opin Nephrol Hypertens 2004; 13:533-540.