Interleukin-6 gene polymorphism in renal transplant patients with and without gingival overgrowth

Journal of Clinical Periodontology

Volumn 32, Issue 9, 2005, Pages 955-958

  Drozdzik, M ^a   Kurzawski, M ^a   Drozdzik, A ^a   Kotrych, K ^a   Banach, J ^a   Pawlik, A ^a  

^a POMERANIAN MEDICAL UNIVERSITY   (Poland)

Author keywords

Gingival overgrowth; Interleukin 6; Polymorphism

Indexed keywords

CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 6;

ADULT; AGED; ALLELE; ARTICLE; CASE CONTROL STUDY; CHEMICALLY INDUCED DISORDER; CHI SQUARE DISTRIBUTION; FEMALE; GENETIC POLYMORPHISM; GENETICS; GINGIVA OVERGROWTH; HUMAN; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; RISK;

ADULT; AGED; ALLELES; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CYCLOSPORINE; FEMALE; GINGIVAL OVERGROWTH; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-6; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, GENETIC;

EID: 23844491661     PISSN: 03036979     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2005.00766.x     Document Type: Article

References (21)

1. Afonso, M., de Oliveira Bello, V., Shibli, J. A. & Sposto, M. R. (2003) Cyclosporine A-induced gingival overgrowth in renal transplant recipients. Journal of Periodontology 74, 51-56.
2. Brull, D. J., Montgomery, H. E., Sanders, J., Dhamrait, S., Luong, L., Rumley, A., Lowe, G. D. & Humphries, S. E. (2001) Interleukin-6 gene - 174G > C and - 572G > C promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery. Arteriosclerosis, Thrombosis and Vascular Biology 21, 1458-1463.
3. Duncan, M. R. & Berman, B. (1991) Stimulation of collagen and glycosaminoglycan production in cultured human adult dermal fibroblasts by recombinant human interleukin-6. Journal of Investigative Dermatology 97, 686-689.
4. Fishman, D., Faulds, G., Jeffery, R., Mohamed-Ali, V., Yudin, J. S., Humphries, S. & Woo, P. (1998) The effect of novel polymorphism in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. Journal of Clinical Investigation 102, 1369-1376.
5. Fries, K. M., Felch, M. & Phipps, R. (1994) Interleukin-6 is an autocrine growth factor for murine lung fibroblast subsets. American Journal of Respiratory Cell Molecular Biology 11, 552-560.
6. Holla, L. I., Fassmann, A., Stejskalova, A., Znojil, V., Vanek, J. & Vacha, J. (2004) Analysis of the interleukin-6 gene promoter polymorphisms in Czech patients with chronic periodontitis. Journal of Periodontology 75, 30-36.
7. Jones, K. G., Brull, D. J., Brown, L. C., Sian, M., Greenhalgh, R. M., Humphries, S. E. & Powell, J. T. (2001) Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysm. Circulation 103, 2260-2265.
8. Kanabrocki, E. L., Sothern, R. B., Messmore, H. L., Roitman-Johnson, B., McCormick, J. B., Dawson, S., Bremner, S. W., Third, J. L., Nemchausky, B. A., Shirazi, P. & Scheving, L. E. (1999) Circadian interrelationships among levels of plasma fibrinogen, blood plasma and serum interleukin-6. Clinical and Applied Thrombosis and Hemostasis 5, 37-42.
9. Margiotta, V., Pizzo, I., Pizzo, G. & Barbara, A. (1996) Cyclosporine- and nifedipine-induced gingival overgrowth in renal transplant patients: correlations with periodontal and pharmacological parameters, and HLA-antigens. Journal Oral Pathology & Medicine 25, 128-134.
10. Morse, H. R., Olomolaiye, O. O., Wood, N. A., Keen, L. J. & Bidwell, J. L. (1999) Induced heteroduplex genotyping of TNF-α, IL-1β, IL-6 and IL-10 polymorphisms associated with transcriptional regulation. Cytokine 11, 789-795.
11. Morton, R. S. & Dongari-Bagtzoglou, A. I. (1999) Regulation of gingival fibroblast interleukin-6 secretion by cyclosporine A. Journal of Periodontology 70, 1464-1471.
12. Myrillas, T., Linden, G. J., Marley, J. J. & Irwin, C. R. (1999) Cyclosporine A regulates interleukin-1β and interleukin-6 expression in gingiva: implications for gingival overgrowth. Journal of Periodontology 70, 294-300.
13. Pernu, H. E., Pernu, L. M., Huttunen, K. R., Nieminen, P. A. & Knuuttila, M. L. (1992) Gingival overgrowth among renal transplant recipients related to immunosuppressive medication and possible local background factors. Journal of Periodontology 62, 548-553.
14. Rostock, M. H., Fryt, H. R. & Turner, J. E. (1986) Severe gingival overgrowth associated with cyclosporine therapy. Journal of Periodontology 57, 294-299.
15. Seymour, R. A., Thomason, J. M. & Ellis, J. S. (1996) The pathogenesis of drug-induced gingival overgrowth. Journal of Clinical Periodontology 23, 165-175.
16. Shin, G. T., Khanna, A., Ding, R., Sharma, V. K., Lagman, M., Li, B. & Sunathiran, M. (1998) In vivo expression of transforming growth factor-β1. Transplantation 65, 313-318.
17. Somacarrera, M. L., Hernandez, G., Acero, J. & Moskow, B. S. (1994) Factors relating to the incidence and severity of cyclosporine-induced gingival overgrowth in transplant patients. A longitudinal study. Journal of Periodontal Research 65, 671-675.
18. Terry, C. F., Loukaci, V. & Green, F. (2000) Cooperative influence of genetic polymorphisms on interleukin-6 transcriptional regulation. Journal of Biochemical Chemistry 275, 18138-18144.
19. Thomas, D. W., Baboolal, K., Subtamanian, N. & Newcombe, R. G. (2001) Cyclosporine A-induced gingival overgrowth is unrelated to allograft function in renal transplant recipients. Journal of Clinical Periodontology 28, 706-709.
20. Thomas, D. W., Newcombe, R. G. & Osborne, G. (2000) Risk factors in the development of cyclosporine-induced gingival overgrowth. Transplantation 70, 552-556.
21. Trevilatto, P. C., Scarel-Caminaga, R. M., de Brito, R. B. Jr., de Souza, A. P. & Line, S. P. (2003) Polymorphim at position - 174 of IL-6 gene is associated with susceptibility to chronic periodontitis in a Caucasian Brasilian population. Journal of Clinical Periodontology 30, 438-442.