Somatropin for the treatment of short bowel syndrome in adults

Expert Opinion on Pharmacotherapy

Volumn 6, Issue 10, 2005, Pages 1741-1750

  Matarese, Laura E ^a   Abu Elmagd, Kareem ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Intestinal failure; Short bowel syndrome; Somatropin

Indexed keywords

GHRELIN; GLUCAGON LIKE PEPTIDE 2; GLUTAMINE; GROWTH HORMONE; GROWTH HORMONE DERIVATIVE; GROWTH HORMONE SECRETAGOGUE; HUMAN GROWTH HORMONE; ORAL REHYDRATION SOLUTION; PLACEBO; PROTHROMBIN; RECOMBINANT DNA; SOMATREM;

ADULT; ALOPECIA; ARTHRALGIA; ARTHRITIS; ARTHROPATHY; ARTICLE; BLEEDING DISORDER; BLOOD CLOTTING DISORDER; BREAST AUGMENTATION; BREAST DISEASE; BRONCHOSPASM; BULLOUS SKIN DISEASE; BURSITIS; CELL LINE; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL TRIAL; DIABETIC COMA; DIABETIC KETOACIDOSIS; DIET SUPPLEMENTATION; DIETARY INTAKE; DISEASE EXACERBATION; DRUG ABSORPTION; DRUG APPROVAL; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG DOSE REGIMEN; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG PURITY; DRUG SAFETY; DRUG TOLERABILITY; DYSPNEA; DYSURIA; EDEMA; FACE EDEMA; GASTROINTESTINAL SYMPTOM; HEART ARRHYTHMIA; HUMAN; HYPERSENSITIVITY REACTION; HYPOMAGNESEMIA; IMPAIRED GLUCOSE TOLERANCE; INFLAMMATION; INJECTION; INJECTION SITE REACTION; INSOMNIA; INTESTINE ABSORPTION; INTESTINE ADAPTATION; INTESTINE FLUID; LONG TERM CARE; MAMMAL CELL; MELENA; MENTAL DISEASE; METABOLIC DISORDER; MOUTH DISEASE; MUSCLE CRAMP; MUSCULOSKELETAL DISEASE; MYALGIA; MYCOSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRIENT; NUTRITIONAL DISORDER; NUTRITIONAL SUPPORT; PAIN; PARENTERAL NUTRITION; PARESTHESIA; PERIPHERAL EDEMA; PERIPHERAL NEUROPATHY; PHANTOM PAIN; PHARYNGITIS; POSTOPERATIVE PERIOD; PURPURA; RECOMBINANT DNA TECHNOLOGY; RECTUM HEMORRHAGE; RESPIRATORY TRACT DISEASE; RESPIRATORY TRACT INFECTION; SHORT BOWEL SYNDROME; SIDE EFFECT; SKIN APPENDAGE DISEASE; SKIN DISEASE; SPORTS DRINK; STEATORRHEA; SWEATING; TACHYCARDIA; THROMBOCYTE DYSFUNCTION; URINARY TRACT DISEASE; URINARY TRACT INFECTION; VAGINITIS; VASCULAR DISEASE; VASODILATATION; VISUAL FIELD DEFECT;

ANIMALS; CLINICAL TRIALS; EDEMA; HUMAN GROWTH HORMONE; HUMANS; SHORT BOWEL SYNDROME;

EID: 23844490880     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.6.10.1741     Document Type: Article

References (40)

1. HOWARD L, AMENT M, FLEMING CR, SHIKE M, STEIGER E: Current use and clinical outcome of home parenteral and enteral nutrition therapies in the United States. Gastroenterology (1995) 109:355-365.
2. HOWARD L, ASHLEY C: Management of complications in patients receiving home parenteral nutrition. Gastroenterology (2003) 124:1651-1661.
3. O'KEEFE SJ, BURNES JU, THOMPSON RL: Recurrent sepsis in home parenteral nutrition patients: an analysis of risk factors. J. Parenter. Enteral. Nutr. (1994) 18:256-263
4. JEPPESEN PB, LANGHOLZ E, MORTENSEN PB: Quality of life in patients receiving home parenteral nutrition. Gut (1999) 44:844-852.
5. BYRNE T, WILMORE DW, IYER K et al.: Growth hormone and an optimal diet with or without glutamine reduces parenteral nutrition in patients with short bowel syndrome. A prospective, randomized, placebo-controlled, double-blind clinical trial. Ann. Surg. (2005) (In press).
6. ZEISEL HJ, VON PETRYKOWSKI W, WAIS U: Pharmacokinetics and short-term metabolic effects of mammalian cell-derived biosynthetic human growth hormone in man. Horm. Res. (1992) 37(Suppl.2):5-13.
7. TRITOS NA, MANTZOROS CS: Recombinant human growth hormone: old and novel uses. Am. J. Med. (1998) Jul 105:44-57.
8. NEY DM, HUSS DJ, GILLINGHAM MB et al.: Investigation of insulin-like growth factor (IGF)-I and insulin receptor binding and expression in jejunum of parenterally fed rats created with IGF-I or growth hormone. Endocrinology (1999) 140:4850-4860.
9. WILLIAMS KL, FULLER CR, FAGIN J, LUND PK: Mesenchymal IGF-I overexpression: parcrine effects in the intestine, distinct from endocrine actions. Am. J. Physiol. (2002) 283:G875-G885.
10. PETERSON CA, CAREY HV, HINTON PL, LO HC, NEY DM: GH elevates serum IGF-I levels but does not alter mucosal atrophy in parenterally fed rats. Am. J. Physiol. (1997) 272:G1100-G1108.
11. WANG G, LEE HM, ENGLANDER E, GREELEY GH Jr.: Ghrelin-not just another stomach hormone. Regul. Pept. (2002) 105 (2):75-81.
12. BROGLIO F, BENSO A, CASTIGLIONI C et al. The endocrine response to ghrelin as a function of gender in humans in yound and elderly subjects. J. Clin. Endocrin. Met. (2003) 88:1537-1542.
13. CUNHA SR, MAYO KE: Ghrelin and growth hormone (GH) secretagogues potentiate GH-releasing hormone (GHRH)-induced cyclinc adenosine 3′, 5′-monophosphate production in cells expressing transfected GHRH and GH secretagogue receptors. Endocrinology (2002) 143:4570-4582.
14. KRSEK M, ROSICKA M, HALUZIK M et al. Plasma ghrelin levels in patients with short bowel syndrome. Endocr. Res. (2002) 1-2:27-33.
15. KRSEK M, ROSICKA M, PAPEZOVA H et al.: Plasma ghrelin levels and malnutriton: a compariosn of two etiologies. Eat Weight Disord (2003) 8:207-11.
16. ZHOU X, LI Y-X, LI N et al.: Glutamine enhances the gut-trophic effect of growth hormone in rat after massive small bowel resection. J. Surg. Res. (2001) 99(1):47-52.
17. GU Y, WU Z-H: The anabolic effects of recombinant human growth hormone and glutamine on parenterally fed, short bowel rats. World J. Gastroenterol. (2002) 8(4):752-757.
18. VANDERHOOF JA, KOLLMAN KA, GRIFFIN S et al.: Growth hormone and glutamine do not stimulate intestinal adaptation following massive small bowel resection in the rat. J. Pediatr. Gastroenterol. Nutr. (1997) Set 25(3):327-331.
19. VERHAGE AH, AGHDASSI E, ALLARD JP: Effects of growth hormone in rats with 80% small bowel resection fed totally by parenteral nutrition. Nutr. Res. (1998) 18(5):823-832.
20. LJUNGMANN K, GROFTE T, KISSMEYER-NIELSEN P et al.: GH decreases hepatic amino acid degradation after small bowel resection in rats without enhancing bowel adaptation. Am. J. Physiol. Gastrointest. Liver Physiol, (2000) 279(4):G700-G706.
21. BENHAMOU PH, CANARELLI JP, RICHARD S et al.: Human recombinant growth hormone increase small bowel lengthening after massive small bowel resection in piglets. J. Pediatr. Surg. (1997) Sept 32(9):1332-1336.
22. NUCCI AM, FINEGOLD DN, YAWORSKI JA et al.: Results of growth trophic therapy in children with short bowel syndrome. J. Pediat. Surg. (2004) 39(3):335-339.
23. BYRNE TA, MORRISSEY TB, NATTAKON TV, ZIEGLER TR, WILMORE DW. Growth hormone, glutamine, and a modified diet enhance nutrient absorption in patients with severe short bowel syndrome. J. Parenter. Enteral. Nutr. (1995) 19:296-302.
24. BYRNE TA, PERSINGER RL, YOUNG LS, ZIEGLER TR, WILMORE DW. A new treatment for patients with short-bowel syndrome. Growth hormone, glutamine, and a modified diet. Ann. Surg. (1995) 222:243-254.
25. WILMORE DW, LACEY JM, SOULTANAKIS RP, BOSCH RL, BYRNE TA. Factors predicting a successful outcome after pharmacologic bowel compensation. Ann. Surg. (1997) 226:288-292.
26. SCOLAPIO JS, CAMILLERI M, FLEMING CR, OENNING LV, BURTON DD, SEBO TJ et al.: Effect of growth hormone, glutamine, and diet on adaptation in short-bowel syndrome: a randomized, controlled study. Gastroenterology (1997) 113:1074-1081.
27. NORDGAARD I, HANSEN BS, MORTENSSEN PB: Colon as a digestive organ in patients with short bowel syndrome. Lancet (1994) 343:373-376.
28. SCOLAPIO JS: Effect of growth hormone, glutamine, and diet on body composition in short bowel syndrome: a randomized, controlled study. J. Parenter. Enteral. Nutr. (1999) 23:309-312.
29. PIETROBELLI A, WANG Z, FORMICA C, HEYMSFIELD SB: Dual-energy X-ray absorptiometry: Fat estimation errors due to variation in soft tissue hydration. Am. J. Physiol. (1998) 274:E808-E816.
30. BYRNE TA, COX S, KARIMBAKAS M et al.: Bowel rehabilitation: an alternative to long-term parenteral nutrition and intestinal transplantation for some patients with short bowel syndrome. Transplant Proceedings (2002) 34:887-890.
31. ZHU W, LI N, REN J, GU J, JIANG J, LI J: Rehabilitation therapy for short bowel syndrome. Clin. Med. J. (2002) 115(5):776-778.
32. WU GH, WU ZH, WU ZG: Effects of bowel rehabilitation and combined trophic therapy on intestinal adaptation in short bowel patients. World J. Gastroenterol. (2003) 9(11):2601-2604.
33. SZKUDLAREK J, JEPPESEN PB, MORTENSEN PB: Effect of high dose growth hormone with glutamine and no change in diet on intestinal absorption in short bowel patients: a randomised, double blind, crossover, placebo-controlled study. Gut (2000) 47:199-205.
34. ELLEGARRD L, BOSAEUS I, NORDGREN S, BENGTSSON BA: Low-dose recombinant human growth hormone increase body weight and lean body mass in patients with short bowel syndrome. Ann. Surg. (1997) 225:88-96.
35. SEGUY D, KOUROCHE V, NATHALIE K, SOUBERBIELLE JC, MESSING B: Low-dose growth hormone in adult home parenteral nutrition-dependent short bowel syndrome patients: a positive study. Gastroenterology (2003) 124(2):293-302.
36. THISSEN JP, KETELSLEGERS JM, UNDERWOOD LE: Nutritional regulation of the insulin-like growth factors. Endocrinology Reviews (1994) 15:80-101.
37. JEPPESEN PB, HARTMANN B, HANSEN BS, THULESEN J, HOLST JJ, MORTENSEN P: Impaired meal stimulated glucagon-like peptide 2 response in ileal resected short bowel patients with intestinal failure. Gut (1999) 45(4):559-563.
38. JEPPESEN PB, HARTMANN B, THULESEN J et al.: Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon. Gastroenterology (2001) 120(4):806-815.
39. ABU-ELMAGD K, BOND G, REYES J, FUNG J: Intestinal transplantation: a coming of age. Adv. Surg. (2002) 36:65-101.
40. GRANT D, ABU-ELMAGD K, REYES J, et al.: 2003 Report of the intestine transplant registry. A new era has dawned. Ann. of Surg. (2005) 241(4):607-613.