Grey-box pharmacokinetic/pharmacodynamic modelling of a euglycaemic clamp study

Journal of Mathematical Biology

Volumn 48, Issue 6, 2004, Pages 591-604

  Tornøe, Christoffer Wenzel ^a,c   Jacobsen, Judith L ^b   Madsen, Henrik ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c Ferring Pharmaceuticals AS   (Denmark)

Author keywords

Compartmental modelling; Euglycaemic clamp; Grey box modelling; Insulin; Kalman filtering; ML estimation; Stochastic differential equations

Indexed keywords

C REACTIVE PROTEIN; DRUG DERIVATIVE; INSULIN; INSULIN ASPART; INSULIN, ASP(B28)-; INSULIN, NEUTRAL;

ADOLESCENT; ADULT; AREA UNDER THE CURVE; ARTICLE; BIOLOGICAL MODEL; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HUMAN; MALE; METABOLISM; METHODOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ADULT; AREA UNDER CURVE; BLOOD GLUCOSE; C-REACTIVE PROTEIN; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; GLUCOSE CLAMP TECHNIQUE; HUMANS; INSULIN; MALE; MODELS, BIOLOGICAL;

EID: 10244238398     PISSN: 03036812     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00285-003-0257-z     Document Type: Article

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