Benefits and concerns regarding folic-acid fortification

Nederlands Tijdschrift voor Klinische Chemie en Laboratoriumgeneeskunde

Volumn 30, Issue 3, 2005, Pages 218-223

  Fokkema, M R ^a   Meijer, W M ^b   De Jong Van Den Berg, L T W ^b  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Cardiovascular disease; Folic acid; Fortification; Neural tube defects; Prevention

Indexed keywords

FOLIC ACID;

BIRTH DEFECT; CANCER; CARDIOVASCULAR DISEASE; CYANOCOBALAMIN DEFICIENCY; DIET SUPPLEMENTATION; DISEASE COURSE; FOLIC ACID BLOOD LEVEL; FOOD INTAKE; HUMAN; MENTAL DISEASE; NEURAL TUBE DEFECT; PREVALENCE; REVIEW; RISK FACTOR;

EID: 23844480398     PISSN: 15708306     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (45)

1. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the medical research council vitamin study. Lancet 1991; 338: 131-137.
2. Czeizel AE, Dudas I. Prevention of fist occurrence of neural tube defects by periconceptional vitamin suppletion. N Engl J Med 1992; 327: 1832-1835.
3. Botto LD, Olney RS, Erickson JD. Vitamin Supplemets and the risk for congenital anomalies other than neural tube defects. Am J of Med Genetics 2004; 125C: 12-21.
4. Bree A de, Verschuren WM, Blom HJ, Nadeau M, Trijbels FJ, Kromhout D. Coronary heart disease mortality, plasma homocysteine, and B-vitamins: a prospective study. Atherosclerosis 2003; 166: 369-377.
5. Voutilainen S, Lakka TA, Porkkala-Sarataho E, Rissanen T, Kaplan GA, Salonen JT. Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study. Eur J Clin Nutr 2000; 54: 424-428.
6. Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 2002; 325: 1202-1208.
7. Hankey GJ, Eikelboom JW, Ho WK, Bockxmeer FM van. Clinical usefulness of plasma homocysteine in vascular disease. Med J Aust 2004; 181: 314-318.
8. Nederlandse Hartstichting. Homocysteine en hart- en vaatziekten. Den Haag, 2001.
9. Aubard Y, Darodes N, Cantaloube M. Hyperhomocysteinemia and pregnancy-review of our present understanding and therapeutic implications. Eur J Obstet Gynecol Reprod Biol 2000; 93: 157-165.
10. Eskes TK. Homocysteine and human reproduction. Clin Exp Obstet Gynecol 2000; 27: 157-167.
11. Reutens S, Sachdev P. Homocysteine in neuropsychiatric disorders of the elderly. Int J Geriatr Psychiatry 2002; 17: 859-864.
12. Kim YI. Will mandatory folic acid fortification prevent or promote cancer? Am J Clin Nutr 2004; 80: 1123-1128.
13. Institute of Medicine. Folate. In: Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Washington, DC: National Academy Press, 1998: 196-305.
14. US Department of Health and Human Services, Food, and Drug Administration, Food standards: amendment of the standards of identity for enriched grain product to require addition of folic acid. Fed Regist 1996; 61: 8781.
15. French AE, Grant R, Weitzman S. Folic acid food fortification is associated with a decline in neuroblastoma. Clin Pharmacol Ther 2003; 74: 288-294.
16. Czeizel AE, Metneki J, Dudas I. The higher rate of multiple births after periconceptional multivitamin supplementation: an analysis of causes. Acta Genet Med Gemellol (roma) 1994; 43: 175-184.
17. Werler MM, Cragan JD, Wasserman CR, Shaw GM, Erickson JD, Mitchell AA. Multivitamin supplementation and multiple births. Am J Med Genet 1997; 71: 93-96.
18. Ericson A, Kallen B, Aberg A. Use of multivitamins and folic acid in early pregnancy and multiple births in Sweden. Twin Res 2001; 4: 63-66.
19. Kallen B. Use of folic acid supplementation and risk for dizygotic twinning. Early Human Development 2004; 80: 143-151.
20. Li Z, Gindler J, Wang H, Berry RJ, Li S, Correa A, Zheng J, Erickson JD, Wang Y. Folic acid supplements during early pregnancy and likelihood of multiple births: a population-based cohort study. Lancet 2003; 361: 380-384.
21. Ray JG, Laskin CA. Folic acid and homocysteine metabolic defects and the risk of placental abruption, preeclampsia and spontaneous pregnancy loss: a systematic review. Placenta 1999; 20: 519-529.
22. Gindler J, Li Z, Zheng J, Correa A, Sun X, Wong L, Cheng L, Erickson JD, Wang Y, Tong Q. Folic acid supplements during pregnancy and risk of miscarriage. Lancet 2001; 358: 796-800.
23. George L, Mills JL, Johansson AL, Nordmark A, Olander B, Granath F, Cnattingius S. Plasma folate levels and risk of spontaneous abortion. JAMA 2002; 288: 1867-1873.
24. Konings EJ, Roomans HH, Dorant E, Goldbohm RA, Saris WH, Brandt PA van den. Folate intake of the Dutch population according to newly established liquid chromatography data for foods. Am J Clin Nutr 2001; 73: 765-776.
25. Voutilainen S, Rissanen TH, Virtanen J, Lakka TA, Salonen JT; Kuopio Ischemic Heart Disease Risk Factor Study. Low dietary folate intake is associated with an excess incidence of acute coronary events: The Kuopio Ischemic Heart Disease Risk Factor Study. Circulation 2001; 103: 2674-2680.
26. Buller DB, Morrill C, Taren D, Aickin M, Sennott-Miller L, Buller MK et al. Randomized trial testing the effect of peer education at increasing fruit and vegetable intake. J Natl Cancer Inst 1999; 91: 1491-1500.
27. Pignone MP, Ammerman A, Fernandez L, Orleans CT, Pender N, Woolf S et al. Counseling to promote a healthy diet in adults. A summary of the evidence for the U.S. Preventive Services Task Force. Am J Prev Med 2003; 24: 75-92.
28. Homocysteine Lowering Trialists' Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. BMJ 1998; 316: 894-898.
29. Venn BJ, Mann JI, Williams SM, Riddell LJ, Chisholm A, Harper MJ et al. Dietary counselling to increase natural folate intake: a randomized, placebo-controlled trial in free-living subjects to assess effects on serum folate and plasma total homocysteine. Am J Clin Nutr 2002; 76: 758-765.
30. Riddell LJ, Chisholm A, Williams S, Mann JI. Dietary strategies for lowering homocysteine concentrations. Am J Clin Nutr 2000; 71: 1448-1454.
31. Adank C, Green TJ, Murray Skeaff C, Briars B. Weekly high dose folic acic supplementation is effective in lowering serum homocysteine concentrations in women. Ann Nutr Metab 2003; 47: 55-59.
32. Brouwer IA, van Rooij IA, Dusseldorp M van, Thomas CM, Blom HJ, Hautvast JG, Eskes TK, Steegers-Theunissen RP. Homocysteine-lowering effect of 500 microg folic acid every other day versus 250 microg/day. Ann Nutr Metab 2000; 44: 194-197.
33. Norsworthy B, Murray Skeaff C, Adank C, Green TJ. Once-a-week folic acid supplement increases red blood cell folate concentrations in women. Eur J Clin Nutr 2004; 48: 548-554.
34. Daly S, Mills JL, Molloy AM, Conley M, Lee YJ, Kirke PN, Weir DG, Scott JM. Minimum effective dose of folic acid for food fortification to prevent neural-tube defects. Lancet 1997; 350: 1666-1669.
35. Daly LE, Kirke PN, et al. Folate levels and neural tube defects. Implications for prevention. JAMA 1995; 274: 1698-1702.
36. Wald NJ, Law MR, Morris JK, Wald DS. Quantifying the effect of folic acid. Lancet 2001; 358: 2069-2073.
37. Oakley GP. Inertia on folic acid fortification: public health malpractice. Teratology 2002; 66: 44-54.
38. Oakley GP, Johnston RB. Balancing benefits and harms in public health prevention programs mandated by governments. BMJ 2004; 329: 41-43.
39. EUROCAT folic acid working group. Prevention of Neural Tube Defects by Periconceptional Folic Acid Supplementation in Europe. 2003. www.eurocat.ulst.ac.uk/ pdf/Part%20I.pdf.
40. Walle HEK de, Jong-van den Berg LTW de. Insufficient folic acid intake in the Netherlands: What about the future? Teratology 2002; 66: 40-43.
41. Ray JG, Singh G, Burrows RF. Evidence for suboptimal use of periconceptional folic acid supplements globally. BJOG 2004; 111: 399-408
42. Honein MA, Paulozzi LJ, Mathews TJ, Ericson JD, Wong LY. Impact of folic acid fortification on the US food supply on the occurrence of neural tube defects. JAMA 2001; 285: 2981-2986.
43. Persad VL, Van den Hof MC, Dube JM, Zimmer P. Incidence of open neural tube defects in Nova Scotia after folic acid fortification. CMAJ 2002; 167: 241-245.
44. Bower C, Ryan A, Rudy E, Miller M. Trends in neural tube defects in Western Australia. Austr N Z J Public Health 2002; 26: 150-151.
45. Meijer MW, de Smit DJ, Jurgens RA and de Jong-van den Berg LTW. Improved periconceptional use of folic acid after patient education in pharmacies: promising results of a pilot study in the Netherlands. IJPP 2005; 13: 47-51.