The anti-tumor effect of interleukin-12 is enhanced by mild (fever-range) thermal therapy

Immunological Investigations

Volumn 34, Issue 3, 2005, Pages 361-380

  Pritchard, M T ^a   Wolf, S F ^b   Kraybill, W F ^a   Repasky, Elizabeth A ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b PFIZER INC   (United States)

Author keywords

Inducible nitric oxide synthase; Interleukin 12; Nitric oxide; Whole body hyperthermia

Indexed keywords

CYTOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CONTROL; CANCER THERAPY; CELLULAR IMMUNITY; DRUG EFFECT; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FEVER; HYPERTHERMIA; HYPERTHERMIC THERAPY; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STIMULUS RESPONSE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; FEMALE; HYPERTHERMIA, INDUCED; INTERFERON TYPE II; INTERFERON-GAMMA; INTERLEUKIN-12; MACROPHAGES; MICE; MICE, INBRED BALB C; NITRIC OXIDE; TIME FACTORS;

EID: 23844477461     PISSN: 08820139     EISSN: 15324311     Source Type: Journal    
DOI: 10.1081/IMM-200067646     Document Type: Article

References (42)

1. Baba, H., Siddik, Z. H., Strebel, F. R., Jenkins, G. N., Bull, J. M. (1989). Increased therapeutic gain of combined cis-diamminedichloroplatinum (II) and whole body hyperthermia therapy by optimal heat/drug scheduling. Cancer Res. 49:7041-7044.
2. Bogdan, C. (2001). Nitric oxide and the immune response. Nat. Immunol. 2:907-916. [comment].
3. Brunda, M. J., Gately, M. K. (1994). Antitumor activity of interleukin-12. Clin. Immunol. Immunopathol. 71:253-255.
4. Brunda, M. J., Luistro, L., Hendrzak, J. A., Fountoulakis, M., Garotta, G., Gately, M. K. (1995). Role of interferon-gamma in mediating the antitumor efficacy of interleukin-12. J. Immunother. Emphas. Immunol. 17:71-77.
5. Bukowski, R. M., Rayman, P., Molto, L., Tannenbaum, C. S., Olenki, T., Peereboom, D., Tubbs, R., McLain, D., Budd, G. T., Griffin, T., Novick, A., Hamilton, T. A., Finke, J. H. (1999). Interferon-gamma and CXC chemokine induction by interleukin 12 in renal cell carcinoma. Clin. Cancer Res. 5:2780-2789.
6. Bull, J. M., Nagle, V. L., Scott, G. L., Jordan, S. R., Strebel, F. R., Sheridan, A. E., Koch, S. M., Berry, J. M. (2001). Early results of a phase I study of fever-range, long-duration, low-temperature, whole-body hyperthermia (LL-WBH) optimally-timed with cisplatin (CIS)-gemcitabine (GEM) and interferon-alpha (IFN-alpha). In: Proceedings of the 48th Annual Meeting of the Radiation Research Society and the 19th Annual Meeting of the North American Hyperthermia Society. San Juan, Puerto Rico.
7. Bull, J. M. C., Scott, G. L., Strebel, F. R., Oliver, D. H., Raval, B., Koch, S. M. (2004). Update of a phase I clinical trial using fever-range whole-body hyperthermia (FR-WBH) + Cisplatin (CIS) + Gemcitabine (GEM) + metronomic, low-dose interferon-alpha (IFN-alpha). In: Proceedings of the 7th Meeting of the International Society of Hyperthermic Oncology, St. Louis, MO.
8. Burd, R., Dziedzic, T. S., Xu, Y., Caligiuri, M. A., Subjeck, J. R., Repasky, E. A. (1998). Tumor cell apoptosis, lymphocyte recruitment and tumor vascular changes are induced by low temperature, long duration (fever-like) whole body hyperthermia. J. Cell. Physiol. 177:137-147.
9. Cohen, J. (1995). IL-12 deaths: explanation and a puzzle. Science 270:908.
10. Dinapoli, M. R., Calderon, C. L., Lopez, D. M. (1996). The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduce expression of the inducible nitric oxide synthase gene. J. Exp. Med. 183:1323-1329.
11. Eberl, G., MacDonald, H. R. (2000). Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells. Eur. J. Immunol. 30:985-992.
12. Evans, S. S., Wang, W.-C., Bain, M. D., Burd, R., Ostberg, J. R., Repasky, E. A. (2001). Fever-range hyperthermia dynamically regulates lymphocyte delivery to high endothelial venules. Blood 97:2727-2732.
13. Farias-Eisner, R., Sherman, M. P., Aeberhard, E., Chaudhuri, G. (1994). Nitric oxide is an important mediator for tumoricidal activity in vivo. Proc. Natl. Acad. Sci. U. S. A. 91:9407-9411.
14. Frucht, D. M., Fukao, T., Bogdan, C., Schindler, H., O'Shea, J. J., Koyasu, S. (2001). IFN-gamma production by antigen-presenting cells: mechanisms emerge. Trends Immunol. 22:556-560.
15. Hunter, S. E., Waldburger, K. E., Thibodeaux, D. K., Schaub, R. G., Goldman, S. J., Leonard, J. P. (1997). Immunoregulation by interleukin-12 in MB49.1 tumor-bearing mice: cellular and cytokine-mediated effector mechanisms. Eur. J. Immunol. 27:3438-3446.
16. Lorsbach, R. B., Murphy, W. J., Lowenstein, C. J., Snyder, S. H., Russell, S. W. (1993). Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide. J. Biol. Chem. 268(3):1908-1913.
17. MacMicking, J., Xie, Q. W., Nathan, C. (1997). Nitric oxide and macrophage function. Annu. Rev. Immunol. 15.
18. Nastala, C. L., Edington, H. D., McKinney, T. G., Tahara, H., Nalesnik, M. A., Brunda, M. J., Gately, M. K., Wolf, S. F., Schreiber, R. D., Storkus, W. J. (1994). Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production. J. Immunol. 153:1697-1706.
19. Nathan, C. (1992). Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:3051-3064.
20. Ohno, S., Siddik, Z. H., Baba, H., Stephens, L. C., Strebel, F. R., Wondergem, J., Khokhar, A. R., Bull, J. M. (1991). Effect of carboplatin combined with whole body hyperthermia on normal tissue and tumor in rats. Cancer Res. 51:2994-3000.
21. Ohno, S., Strebel, F. R., Stephens, L. C., Siddik, Z. H., Baba, H., Makino, M., Khokhar, A. R., Bull, J. M. (1993). Haematological toxicity of carboplatin and cisplatin combined with whole body hyperthermia in rats. Br. J. Cancer 68:469-474.
22. Ohno, S., Siddik, Z. H., Kido, Y., Zwelling, L. A., Bull, J. M. (1994). Thermal enhancement of drug uptake and DNA adducts as a possible mechanism for the effect of sequencing hyperthermia on cisplatin-induced cytotoxicity in L1210 cells. Cancer Chemother. Pharmacol. 34:302-306.
23. Ostberg, J. R., Gellin, C., Patel, R., Repasky, E. A. (2001). Regulatory potential of fever-range whole body hyperthermia on Langerhans cells and lymphocytes in an antigen-dependent cellular immune response. J. Immunol. 167:2666-2670.
24. Ostberg, J. R., Kabingu, E., Repasky, E. A. (2003). Thermal regulation of dendritic cell activation and migration from skin expiants. Int. J. Hypertherm. 19:520-533.
25. Pritchard, M. T., Ostberg, J. R., Evans, S. S., Burd, R., Kraybill, W. G., Bull, J. M., Repasky, E. A. (2004). Protocols for simulating the thermal component of fever: preclinical and clinical experience. Methods 32:54-62.
26. Pritchard, M. T., Li, Z., Repasky, E. A. (2005). Nitric oxide production is regulated by fever-range thermal stimulation of murine macrophages. J. Leukoc. Biol. In press.
27. Sakaguchi, Y., Makino, M., Kaneko, T., Stephens, L. C., Strebel, F. R., Danhauser, L. L., Jenkins, G. N., Bull, J. M. (1994). Therapeutic efficacy of long duration-low temperature whole body hyperthermia when combined with tumor necrosis factor and carboplatin in rats. Cancer Res. 54:2223-2227.
28. Sanchez-Bueno, A., Verkhusha, V., Tanaka, Y., Takikawa, O., Yoshida, R. (1996). Interferon-gamma-dependent expression of inducible nitric oxide synthase, interleukin-12, and interferon-gamma-inducing factor in macrophages elicited by allografted tumor cells. Biochem. Biophys. Res. Commun. 224:555-563.
29. Segal, J. G., Lee, N. C., Tsung, Y. L., Norton, J. A., Tsung, K. (2002). The role of IFN-gamma in rejection of established tumors by IL-12: source of production and target. Cancer Res. 62:4696-4703.
30. Storkus, W. J., Tahara, H., Lotze, M. T. (1998). Interleukin-12. In: Thompson, A., ed. The Cytokine Handbook. San Diego: Academic Press Limited.
31. Sumiyoshi, K., Strebel, F. R., Rowe, R. W., Bull, J. M. C. (2003). The effect of whole-body hyperthermia combinded with "metronimic" chemotherapy on rat mammary adenocarcinoma metastases. Int. J. Hypertherm. 19:103-118.
32. Tannenbaum, C. S., Tubbs, R., Armstrong, D., Finke, J. H., Bukowski, R. M., Hamilton, T. A. (1998). The CXC chemokines IP-10 and MIG are necessary for IL-12-mediated regression of the mouse RENCA tumor. J. Immunol. 161:927-932.
33. Toyota, N., Strebel, F. R., Stephens, L. C., Matsuda, H., Bull, J. M. (1997). Long-duration, mild whole body hyperthermia with cisplatin: tumour response and kinetics of apoptosis and necrosis in a metastatic rat mammary adenocarcinoma. Int. J. Hypertherm. 13:497-506.
34. Trinchieri, G. (1995). Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251-276.
35. Trinchieri, G. (2003). Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev., Immunol. 3:133-146.
36. Tsung, K., Meko, J. B., Peplinski, G. R., Tsung, Y. L., Norton, J. A. (1997). IL-12 induces T helper 1-directed antitumor response. J. Immunol. 158:3359-3365.
37. Tsung, K., Dolan, J. P., Tsung, Y. L., Norton, J. A. (2002). Macrophages as effector cells in interleukin 12-induced T cell-dependent tumor rejection. Cancer Res. 62:5069-5075.
38. Voest, E. E., Kenyon, B. M., O'Reilly, M. S., Truitt, G., D'Amato, R. J., Folkman, J. (1995). Inhibition of angiogenesis in vivo by interleukin 12. J. Natl. Cancer Inst. 87:581-586.
39. Wang, X. Y., Ostberg, J. R., Repasky, E. A. (1999). Effect of fever-like whole-body hyperthermia on lymphocyte spectrin distribution, protein kinase C activity, and uropod formation. J. Immunol. 162:3378-3387.
40. Wink, D. A., Vodovotz, Y., Laval, J., Laval, F., Dewhirst, M. W., Mitchell, J. B. (1998). The multifaceted roles of nitric oxide in cancer. Carcinogenesis 19:711-721.
41. Yao, L., Pike, S. E., Setsuda, J., Parekh, J., Gupta, G., Raffeld, M., Jaffe, E. S., Tosato, G. (2000). Effective targeting of tumor vasculature by the angiogenesis inhibitors vasostatin and interleukin-12. Blood 96:1900-1905.
42. Yu, W. G., Yamamoto, N., Takenaka, H., Mu, J., Tai, X. G., Zou, J. P., Ogawa, M., Tsutsui, T., Wijesuriya, R., Yoshida, R., Herrmann, S., Fujiwara, H., Hamaoka, T. (1996). Molecular mechanisms underlying IFN-gamma-mediated tumor growth inhibition induced during tumor immunotherapy with rIL-12. Int. Immunol. 8:855-865.