Efficacy and safety of levocetirizine on symptoms and health-related quality of life of children with perennial allergic rhinitis: A double-blind, placebo-controlled randomized clinical trial

Annals of Allergy, Asthma and Immunology

Volumn 95, Issue 2, 2005, Pages 175-180

  Potter, Paul C ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOCETIRIZINE; PLACEBO;

ARTICLE; CHILD; CLINICAL TRIAL; COMORBIDITY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEADACHE; HUMAN; INFLUENZA; LEARNING; MAJOR CLINICAL STUDY; MALE; OTITIS MEDIA; PERENNIAL RHINITIS; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SOCIAL BEHAVIOR; UPPER RESPIRATORY TRACT INFECTION;

EID: 23844460861     PISSN: 10811206     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1081-1206(10)61208-2     Document Type: Article

References (24)

1. Lack G. Pediatric allergic rhinitis and comorbid disorders. J Allergy Clin Immunol. 2001;108(1 suppl):S9-S15.
2. Lee SL, Wong W, Lau YL. Increasing prevalence of allergic rhinitis but not asthma among children in Hong Kong from 1995 to 2001 (Phase 3 International Study of Asthma and Allergies in Childhood). Pediatr Allergy Immunol. 2004;15:72-78.
3. Weeke ER. Epidemiology of allergic diseases in children. Rhinol Suppl. 1992;13:5-12.
4. Schoenwetter WF. Allergic rhinitis: epidemiology and natural history. Allergy Asthma Proc. 2000;21:1-6.
5. Malone DC, Lawson KA, Smith DH, et al. A cost of illness study of allergic rhinitis in the United States. J Allergy Clin Immunol. 1997;99:22-27.
6. Meltzer EO. Quality of life in adults and children with allergic rhinitis. J Allergy Clin Immunol. 2001;108:S45-S53.
7. Gillman SA, Blatter M, Condemi JJ, et al. The health-related quality of life effects of once-daily cetirizine HCl syrup in children with seasonal allergic rhinitis. Clin Pediatr (Phila). 2002;41:687-696.
8. Lai DS, Lue KH, Hsieh JC, Lin KL, Lee HS. The comparison of the efficacy and safety of cetirizine, oxatomide, ketotifen and a placebo for the treatment of childhood perennial allergic rhinitis. Ann Allergy Asthma Immunol. 2002;89:589-598.
9. Potter PC; Study Group. Levocetirizine is effective for symptom relief including nasal congestion in adolescent and adult (PAR) sensitized to house dust mites. Allergy. 2003;58:893-899.
10. Day JH, Briscoe MP, Rafeiro E, Ratz JD. Comparative onset and duration of action and efficacy of levocetirizine 5 mg and desloratadine 5 mg vs placebo in subjects with seasonal allergic rhinitis exposed to pollen challenge in the environmental exposure unit. Int J Immunorehabil. 2002;4:450-451.
11. Leynadier F, Mees K, Arendt C, Pinelli ME. Efficacy and safety of levocetirizine in seasonal allergic rhinitis. Acta Otorhinolarygol Belg. 2001;55:305-312.
12. Clough GF, Boutsiouki P, Church MK. Comparison of the effects of levocetirizine and loratadine on histamine-induced wheal, flare, and itch in human skin. Allergy. 2001;56:985-988.
13. Devalia JL, De Vos C, Hanotte F, Baltes E. A randomized, double-blind, crossover comparison among cetirizine, levocetirizine, and ucb 28557 on histamine-induced cutaneous responses in healthy adult volunteers. Allergy. 2001;56:50-57.
14. Gandon JM, Allain H. Lack of effect of single and repeated doses of levocetirizine, a new antihistamine drug, on cognitive and psychomotor functions in healthy volunteers. Br J Clin Pharmacol. 2002;54:51-58.
15. Grant JA, Riethuisen JM, Moulaert B, DeVos C. A double-blind randomised single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine and placebo: suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects. Ann Allergy Asthma Immunol. 2002;88:190-197.
16. Hindmarch I, Johnson S, Meadows R, et al. The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance and weal and flare. Curr Med Res Opin. 2001;17: 241-255.
17. Thompson M, Baylock MG, Sexton DW, Campbell A, Walsh GM. Cetirizine and levocetirizine inhibit eotaxin-induced eosinophil transendothelial migration through human dermal or lung microvascular endothelial cells. Clin Exp Allergy. 2002; 32:1-6.
18. Juniper EF, Rowland WC, Roberts NB, Thompson AK, King DR. Measuring quality of life in children with rhinoconjunctivitis. J Allergy Clin Immunol. 1998;101:163-170.
19. Juniper EF, Guyatt GF, Feeny DH, et al. Children and adult perceptions of childhood asthma. Pediatrics. 1997;99:165-168.
20. Vuurman EF, van Veggel LM, Uiterwijk MM, Leutner D, O'Hanlon JF. Seasonal allergic rhinitis and antihistamine effects on children's learning. Ann Allergy. 1993;71:121-126.
21. Fireman P. Therapeutic approaches to allergic rhinitis: treating the child. J Allergy Clin Immunol. 2000;105:S616-S621.
22. Simons FE. Learning impairment and allergic rhinitis. Allergy Asthma Proc. 1996;17:185-189.
23. Guidance for Industry. Allergic Rhinitis: Clinical Development Programs for Drug Products. Washington, DC: US Dept of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research; April 2000.
24. Bachert C, Bousquet J, Canonica GW, et al. Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis. J Allergy Clin Immunol. 2004;114:838-844.