Comparison of the effects of levocetirizine and loratadine on histamine-induced wheal, flare, and itch in human skin

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 56, Issue 10, 2001, Pages 985-988

  Clough, Geraldine F ^a,b   Boutsiouki, P ^a   Church, M K ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Antihistamines; Flare; Ioratadine; Itch; Levocetirizine; Skin; Wheal

Indexed keywords

CETIRIZINE; HISTAMINE; LEVOCETIRIZINE; LORATADINE; PLACEBO; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; ENANTIOMER; FOREARM; HUMAN; LASER FLOWMETER; NORMAL HUMAN; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; STATISTICAL ANALYSIS; URTICARIA;

ANTI-ALLERGIC AGENTS; CETIRIZINE; DOUBLE-BLIND METHOD; HISTAMINE; HUMANS; HYPERSENSITIVITY, IMMEDIATE; LORATADINE; SKIN TESTS; URTICARIA;

EID: 0034853358     PISSN: 01054538     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1398-9995.2001.00204.x     Document Type: Article

References (17)

1. Constitutive activity of the histamine H-I receptor reveals inverse agonism of histamine H-I receptor antagonists
2. Inhibiting effect of cetirizine on histamine-induced and 48/80-induced wheals and flares, experimental dermographism, and cold-induced urticaria
3. Suppression of histamine-induced wheal response by loratadine (SCH 29851) over 28 days in man
4. Cetirizine. A reappraisal of its pharmacological properties and therapeutic use in selected allergic disorders
5. Loratadine. A reappraisal of its pharmacological properties and therapeutic use in allergic disorders
6. A randomised, double-blind, crossover comparison among cetirizine, levocetirizine and ueb 28557 on histamine-induced cutaneous responses in healthy adult volunteers
7. Spatial and temporal variations in human skin blood flow
8. Regulation of FcepsilonARI synthesis in human eosinophils
9. A study of the inflammatory response in human skin using scanning laser Doppler imaging
10. Effects of H-I antagonists on the cutaneous vascular response to histamine and bradykinin: A study using scanning laser Doppler imaging
11. The effect of cetirizine and Ioratadine on codeine-induced histamine release in human skin in vivo assessed by cutaneous microdialysis
12. Consistency of the efficacy of cetirizine and ebastine on skin reactivity
13. Effects of acrivastine, Ioratadine and cetirizine on histamine-induced wheal and flare responses
14. A double-blind, single-dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: Suppression of histamine-induced wheal and flare response for 24 h in healthy male subjects
15. The pharmacokinetics of loratadine in normal geriatric volunteers
16. 1 receptor antagonist. 1. Receptor selectivity, antihistaminic activity, and antiallergenic effects
17. 1 receptor antagonist. II. Lack of central nervous system and cardiovascular effects