Inhibition of MAP-kinase cascade normalizes the proliferation rate of fibroblasts from patients with Type 1 diabetes and nephropathy

Journal of Diabetes and its Complications

Volumn 19, Issue 5, 2005, Pages 291-296

  Maestroni, Anna ^a   Tentori, Francesca ^a   Meregalli, Giancarla ^a   Gabellini, Daniela ^a   Asnaghi, Veronica ^a   Ruggieri, Dora ^a   Zerbini, Gianpaolo ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Cell proliferation; Diabetic nephropathy; Human skin fibroblast; MAP kinase cascade; Type 1 diabetes mellitus

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; MITOGEN ACTIVATED PROTEIN KINASE;

ADULT; ARTICLE; CELL DENSITY; CELL LYSATE; CELL PROLIFERATION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; FIBROBLAST; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ADULT; CELL PROLIFERATION; CELLS, CULTURED; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; FIBROBLASTS; FLAVONOIDS; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES;

EID: 23844442858     PISSN: 10568727     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdiacomp.2005.03.005     Document Type: Article

References (17)

1. T. Dohi, E. Yasugi, and M. Oshima Activation of mitogen activated protein kinase in dolichyl phosphate-induced apoptosis in U937 cells Biochemical and Biophysical Research Communications 224 1996 87 91
2. D.T. Dudley, L. Pang, S.J. Decker, A.J. Bridges, and A.R. Saltiel A synthetic inhibitor of the mitogen-activated protein kinase cascade Proceedings of the National Academy of Sciences of the United States of America 92 1995 7686 7689
3. D.G. Fogarty, M.J. Zychma, L.J. Scott, J.H. Warram, and A.S. Krolewski The C825T polymorphism in the human G-protein beta3 subunit gene is not associated with diabetic nephropathy in Type I diabetes mellitus Diabetologia 41 1998 1304 1308
4. S. Giroux, M. Tremblay, D. Bernard, J.F. Cardin-Girard, S. Aubry, L. Larouche, S. Rousseau, J. Huot, J. Landry, L. Jeannotte, and J. Charron Embryonic death of Mek 1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta Current Biology 9 1999 369 372
5. O.H. Lowry, A.L. Rosenbrough, A.L. Farr, and R.J. Randall Protein measurements with the folin phenol reagent Journal of Biological Chemistry 193 1951 265 275
6. A. Lurbe, P. Fioretto, M. Mauer, M.S. LaPointe, and D. Batlle Growth phenotype of cultured skin fibroblasts from IDDM patients with and without nephropathy and overactivity of the Na/H antiporter Kidney International 50 1996 1684 1693
7. C.J. Marshall Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation Cell 80 1995 179 185
8. A. Morocutti, K.A. Earle, M. Sethi, G. Piras, K. Pal, D. Richards, P. Rodemann, and G.C. Viberti Premature senescence of skin fibroblasts from insulin-dependent diabetic patients with kidney disease Kidney International 50 1996 250 256
9. J. Pouyssegur, and K. Seuwen Transmembrane receptors and intracellular pathways that control cell proliferation Annual Review of Physiology 54 1992 195 210
10. H.J. Schaeffer, and M.J. Weber Mitogen-activated protein kinases: Specific messages from ubiquitous messengers Molecular and Cellular Biology 19 1999 2435 2444
11. W. Siffert, D. Rosskopf, A. Moritz, T. Wieland, S. Kaldenberg-Stasch, N. Kettler, K. Hartung, S. Beckmann, and K.H. Jakobs Enhanced G protein activation in immortalized lymphoblasts from patients with essential hypertension Journal of Clinical Investigation 96 1995 759 766
12. W. Siffert, D. Rosskopf, G. Siffert, S. Busch, A. Moritz, R. Erbel, A.M. Sharma, E. Ritz, H.E. Wichmann, K.H. Jacobs, and B. Horsthemke Association of a human G-protein b3 subunit variant with hypertension Nature Genetics 18 1998 45 48
13. Y. Terada, K. Tomita, M.K. Homma, H. Nonoguchi, T. Yang, T. Yamada, Y. Yuasa, E.G. Krebs, S. Sasaki, and F. Marumo Sequential activation of Raf-1 kinase, mitogen-activated protein (MAP) kinase kinase, MAP kinase, and S6 kinase by hyperosmolality in renal cells Journal of Biological Chemistry 269 1994 31296 31301
14. R. Trevisan, L.K. Li, J. Messent, T. Tariq, K. Earle, J.D. Walker, and G.C. Viberti Na/H antiport activity and cell growth in cultured skin fibroblasts of IDDM patients with nephropathy Diabetes 41 1992 1239 1246
15. Y. Wan, T. Kurosaki, and X.-Y. Huang Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors Nature 380 1996 541 544
16. G. Zerbini, R. Mangili, D. Gabellini, and G. Pozza Modes of operation of an electroneutral Na/Li countertransport in human skin fibroblasts American Journal of Physiology 272 1997 C1373 C1379
17. G. Zerbini, G. Meregalli, L. Cornaghi, R. Mangili, and G. Pozza Tetraploid cells and diabetic nephropathy Diabetologia 42 1999 118