Significance of proximal tubular metabolism of advanced glycation end products in kidney diseases

Annals of the New York Academy of Sciences

Volumn 1043, Issue , 2005, Pages 637-643

  Saito, Akihiko ^a   Takeda, Tetsuro ^a   Sato, Kiyoko ^a   Hama, Hitomi ^a   Tanuma, Atsuhito ^a   Kaseda, Ryohei ^a   Suzuki, Yoshiki ^a,b   Gejyo, Fumitake ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

Advanced glycation end product; Chronic renal failure; Diabetic nephropathy; Megalin; Proximal tubule

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; CARBOHYDRATE DERIVATIVE; CARBONYL DERIVATIVE; CARRIER PROTEIN; MEGALIN; PROTEIN; UREMIC TOXIN;

ADOPTIVE IMMUNOTHERAPY; AMYLOIDOSIS; BIOACCUMULATION; BLOOD LEVEL; CHRONIC KIDNEY FAILURE; CONFERENCE PAPER; DEGRADATION; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DIALYSIS; ENDOCYTOSIS; GLOMERULUS FILTRATION; GLYCATION; HUMAN; KIDNEY DISEASE; KIDNEY METABOLISM; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; MOLECULAR WEIGHT; PATHOGENESIS; PROTEINURIA; UREMIA;

EID: 23744506885     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1333.072     Document Type: Conference Paper

References (38)

1. VLASSARA, H. 2001. The AGE-receptor in the pathogenesis of diabetic complications. Diabetes Metab. Res. Rev. 17: 436-443.
2. GUGLIUCCI, A. & M. BENDAYAN. 1996. Renal fate of circulating advanced glycated end products (AGE): evidence for reabsorption and catabolism of AGE-peptides by renal proximal tubular cells. Diabetologia 39: 149-160.
3. MIYATA, T., Y. UEDA, K. HORIE, et al. 1998. Renal catabolism of advanced glycation end products: the fate of pentosidine. Kidney Int. 53: 416-422.
4. GILBERT, R.E. & M.E. COOPER. 1999. The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury? Kidney Int. 56: 1627-1637.
5. SIMM, A., G. MUNCH, F. SEIF, et al. 1997. Advanced glycation endproducts stimulate the MAP-kinase pathway in tubulus cell line LLC-PK1. FEBS Lett. 410: 481-484.
6. SEBEKOVA, K., R. SCHINZEL, H. LING, et al. 1998. Advanced glycated albumin impairs protein degradation in the kidney proximal tubules cell line LLC-PK1. Cell. Mol. Biol. 44: 1051-1060.
7. VERBEKE, P., M. PERICHON, B. FRIGUET, et al. 2000. Inhibition of nitric oxide synthase activity by early and advanced glycation end products in cultured rabbit proximal tubular epithelial cells. Biochim. Biophys. Acta 1502: 481-494.
8. MORCOS, M., A.A. SAYED, A. BIERHAUS, et al. 2002. Activation of tubular epithelial cells in diabetic nephropathy. Diabetes 51: 3532-3544.
9. YAMAGISHI, S., Y. INAGAKI, T. OKAMOTO, et al. 2003. Advanced glycation end products inhibit de novo protein synthesis and induce TGF-β overexpression in proximal tubular cells. Kidney Int. 63: 464-473.
10. OLDFIELD, M.D., L.A. BACH, J.M. FORBES, et al. 2001. Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE). J. Clin. Invest. 108: 1853-1863.
11. WENDT, T., N. TANJI, J. GUO, et al. 2003. Glucose, glycation, and RAGE: implications for amplification of cellular dysfunction in diabetic nephropathy. J. Am. Soc. Nephrol. 14: 1383-1395.
12. SAKURAI, S., H. YONEKURA, Y. YAMAMOTO, et al. 2003. The AGE-RAGE system and diabetic nephropathy. J. Am. Soc. Nephrol. 14(Suppl. 3): S259-S263.
13. TANJI, N., G.S. MARKOWITZ, C. FU, et al. 2000. Expression of advanced glycation end products and their cellular receptor RAGE in diabetic nephropathy and nondiabetic renal disease. J. Am. Soc. Nephrol. 11: 1656-1666.
14. VLASSARA, H., Y.M. LI, F. IMANI, et al. 1995. Identification of galectin-3 as a high-affinity binding protein for advanced glycation end products (AGE): a new member of the AGE-receptor complex. Mol. Med. 1: 634-646.
15. ARAKI, N., T. HIGASHI, T. MORI, et al. 1995. Macrophage scavenger receptor mediates the endocytic uptake and degradation of advanced glycation end products of the Maillard reaction. Eur. J. Biochem. 230: 408-415.
16. SUZUKI, H., Y. KURIHARA, M. TAKEYA, et al. 1997. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 386: 292-296.
17. OHGAMI, N., R. NAGAI, M. IKEMOTO, et al. 2001. CD36, a member of the class B scavenger receptor family, as a receptor for advanced glycation end products. J. Biol. Chem. 276: 3195-3202.
18. OHGAMI, N., R. NAGAI, A. MIYAZAKI, et al. 2001. Scavenger receptor class B type I-mediated reverse cholesterol transport is inhibited by advanced glycation end products. J. Biol. Chem. 276: 13348-13355.
19. HENLE, T. & T. MIYATA. 2003. Advanced glycation end products in uremia. Adv. Ren. Replace. Ther. 10:321-331.
20. MIYATA, T., Y. UEDA, A. SAITO, et al. 2000. 'Carbonyl stress' and dialysis-related amyloidosis. Nephrol. Dial. Transplant. 15 (Suppl. 1): 25-28.
21. MAKITA, Z., S. RADOFF, E.J. RAYFIELD, et al. 1991. Advanced glycosylation end products in patients with diabetic nephropathy. N. Engl. J. Med. 325: 836-842.
22. MAKITA, Z., R. BUCALA, E.J. RAYFIELD, et al. 1994. Reactive glycosylation endproducts in diabetic uraemia and treatment of renal failure. Lancet 343: 1519-1522.
23. MIYATA, T., Y. UEDA, Y. YAMADA, et al. 1998. Accumulation of carbonyls accelerates the formation of pentosidine, an advanced glycation end product: carbonyl stress in uremia. J. Am. Soc. Nephrol. 9: 2349-2356.
24. PACIFICI, G.M., A. VIANI, M. FRANCHI, et al. 1989. Profile of drug-metabolizing enzymes in the cortex and medulla of the human kidney. Pharmacology 39: 299-308.
25. SAITO, A., S. PIETROMONACO, A.K. LOO, et al. 1994. Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family. Proc. Natl. Acad. Sci. USA 91: 9725-9729.
26. CHRISTENSEN, E.I. & H. BIRN. 2002. Megalin and cubilin: multifunctional endocytic receptors. Nat. Rev. Mol. Cell. Biol. 3: 256-266.
27. HAMA, H., A. SAITO, T. TAKEDA, et al. 2004. Evidence indicating that renal tubular metabolism of leptin is mediated by megalin but not by the leptin receptors. Endocrinology 145: 3935-3940.
28. KOZYRAKI, R. 2001. Cubilin, a multifunctional epithelial receptor: an overview. J. Mol. Med. 79: 161-167.
29. + exchanger isoform NHE3 in the proximal tubule. J. Biol. Chem. 274: 17518-17524.
30. HRYCIW, D.H., E.M. LEE, C.A. POLLOC & P. PORONNIK. 2004. Molecular changes in proximal tubule function in diabetes mellitus. Clin. Exp. Pharmacol. Physiol. 31: 372-379.
31. OLEINIKOV, A.V., J. ZHAO, S.P. MAKKER, et al. 2000. Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin. Biochem. J. 347(Pt. 3): 613-621.
32. RADER, K., R.A. ORLANDO, X. LOU, et al. 2000. Characterization of ANKRA, a novel ankyrin repeat protein that interacts with the cytoplasmic domain of megalin. J. Am. Soc. Nephrol. 11: 2167-2178.
33. PATRIE, K.M., A.J. DRESCHER, M. GOYAL, et al. 2001. The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes. J. Am. Soc. Nephrol. 12: 667-677.
34. LOU, X., T. MCQUISTAN, R.A. ORLANDO, et al. 2002. GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function. J. Am. Soc. Nephrol. 13: 918-927.
35. PETERSEN, H.H., J. HILPERT, D. MILITZ, et al. 2003. Functional interaction of megalin with the megalin binding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. J. Cell. Sci. 116: 453-461.
36. NAGAI, M., T. MEERLOO, T. TAKEDA, et al. 2003. The adaptor protein ARH escorts megalin to and through endosomes. Mol. Biol. Cell 14: 4984-4996.
37. SAITO, A., R. NAGAI, A. TANUMA, et al. 2003. Role of megalin in endocytosis of advanced glycation end products: implications for a novel protein binding to both megalin and advanced glycation end products. J. Am. Soc. Nephrol. 14: 1123-1131.
38. SAITO, A., J.J. KAZAMA, N. IINO, et al. 2003. Bioerigineered implantation of megalin-expressing cells: a potential intracorporeal therapeutic model for uremic toxin protein clearance in renal failure. J. Am. Soc. Nephrol. 14: 2025-2032.