Interspecific structural differences in nucleosome as revealed by heteroimmunization in mice with human nucleosome

Annals of the New York Academy of Sciences

Volumn 1050, Issue , 2005, Pages 89-96

  Kanai, Yoshiyuki ^a,b   Watanabe, M ^c   Kubota, T ^c  

^a Fukushimura Institute of Health and Medical Services for the Aged   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Epitope spreading; High pressure liquid chromatography; IgG subclass; Nucleosome

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2B; NUCLEOSOME ANTIBODY;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; ANIMAL EXPERIMENT; AUTOIMMUNITY; BINDING AFFINITY; BIOCHEMISTRY; CELL DIFFERENTIATION; CELL LINE; CELL STRUCTURE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOLOGY; IN VIVO STUDY; LUPUS ERYTHEMATOSUS NEPHRITIS; MOUSE; NONHUMAN; NUCLEOSOME; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 23744502632     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1313.010     Document Type: Conference Paper

References (16)

1. KORNBERG, R.D. 1974. Chromatin structure: a repeating unit of histones and DNA. Science 184: 868-871.
2. KORNBERG, R.D. 1999. Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell 98: 285-294.
3. KORNBERG, R.D., J.R. LAPOINTE & Y. LORCH. 1989. Preparation of nucleosomes and chromatin. Methods Enzymol. 170: 3-14.
4. KOUTOUZOV, S. et al. 1996. Binding of nucleosomes to a cell surface receptor: redistribution and endocytosis in the presence of lupus antibodies. Eur. J. Immunol. 26: 472-486.
5. CABRESPINES, A. et al. 1998. Isolation and characterization of apoptotic nucleosomes, free and complexed with lupus autoantibody generated during hybridoma B-cell apoptosis. J. Autoimmun. 11: 19-27.
6. MOUNTZ, J.D., J. WU, J. CHENG & T. ZHOU. 1994. Autoimmune disease: a problem of defective apoptosis. Arthritis Rheum. 37: 1415-1420.
7. UTZ, P.J. & P. ANDERSON. 1998. Posttranslational protein modifications, apoptosis, and the bypass of tolerance to autoantigens. Arthritis Rheum. 41: 1152-1160.
8. TAN, E.M. 1989. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv. Immunol. 44: 93-151.
9. AMOURA, Z. et al. 1994. Nucleosome-restricted antibodies are detected before anti-dsDNA and/or antihistone antibodies in serum of MRL-Mp lpr/lpr and +/+ mice with proteinuria. Arthritis Rheum. 37: 1684-1688.
10. CHABRE, H. et al. 1995. Presence of nucleosome-restricted antibodies in patients with systemic lupus erythematosus. Arthritis Rheum. 38: 1485-1491.
11. AMOURA, Z. et al. 2000. Presence of antinucleosome antibodies in a restricted set of connective tissue diseases: antinucleosome antibodies of the IgG3 subclass are markers of renal pathogenicity in systemic lupus erythematosus. Arthritis Rheum. 43: 76-84.
12. KANAI, Y. et al. 1986. An established MRL/Mp-lpr/lpr cell line with null cell properties produces a B cell differentiation factor(s) that promotes anti-single-stranded DNA antibody production in MRL spleen cell culture. Int. Arch. Allergy. Appl. Immunol. 81: 92-94.
13. KANAI, Y., S. KYUWA, K. MIURA & Y. KUROSAWA. 1995. Induction and natural occurrence of serum nucleosomal DNA in autoimmune MRL/lpr/lpr mice: its relation to apoptosis in the thymus. Immunol. Lett. 46: 207-214.
14. LUTTER, L.C. 1978. Kinetic analysis of deoxyribonuclease I cleavages in the nucleosome core: evidence for a DNA superhelix. J. Mol. Biol. 124: 391-420.
15. UMESH, S. 2003. Mechanisms of autoantibody diversification to SLE-related autoantigens. Ann. N. Y. Acad. Sci. 987: 91-98.
16. XIAN, J., M.G. HARRINGTON & E.H. DAVIDSON. 1996. DNA-binding assays from a single sea urchin egg: a high-sensitivity capillary electrophoresis method. Proc. Natl. Acad. Sci. USA 93: 86-90.