PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage

Journal of Cell Science

Volumn 118, Issue 13, 2005, Pages 2913-2921

  Li, Shaohua ^a   Bordoy, Randi ^b,c   Stanchi, Fabio ^b   Moser, Markus ^b   Braun, Attila ^b   Kudlacek, Oliver ^b   Wewer, Ulla M ^c   Yurchenco, Peter D ^a   Fässler, Reinhard ^b  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Adhesion; ILK; Implantation; Integrin; PINCH (LIMS1); PKB Akt

Indexed keywords

ACTIN; BETA1 INTEGRIN; BINDING PROTEIN; INTEGRIN LINKED KINASE; MUTANT PROTEIN; PROTEIN KINASE B; PROTEIN PINCH1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; CELL ADHESION; CELL FUNCTION; CELL POLARITY; CELL SURVIVAL; CONTROLLED STUDY; ECTODERM; EMBRYO; EMBRYONIC STEM CELL; ENDODERM; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; GENE DISRUPTION; IMMUNOHISTOCHEMISTRY; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONTENT; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STEM CELL TRANSPLANTATION;

ACTINS; ANIMALS; APOPTOSIS; CELL ADHESION; CELL POLARITY; CELL SURVIVAL; DNA-BINDING PROTEINS; EMBRYO; EMBRYO IMPLANTATION; EXTRACELLULAR MATRIX; MICE; MOLECULAR SEQUENCE DATA; TIGHT JUNCTIONS;

ANIMALIA;

EID: 23744490092     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.02422     Document Type: Article

References (28)

1. Aumailley, M., Pesch, M., Tunggal, L., Gaill, F. and Fässler, R. (2000). Altered synthesis of laminin 1 and absence of basement membrane component deposition in β1 integrin-deficient embryoid bodies. J. Cell Sci. 113, 259-268.
2. Brakebusch, C. and Fässler, R. (2003). The integrin-actin connection, an eternal love affair. EMBO J. 22, 2324-2333.
3. Braun, A., Bordoy, R., Stanchi, F., Moser, M., Kostka, G., Ehler, E., Brandau, O. and Fässler, R. (2003). PINCH2 is a new five LIM domain protein, homologous to PINCH and localized to focal adhesions. Exp. Cell Res. 284, 239-250.
4. Campana, W. M., Myers, R. R. and Rearden, A. (2003). Identification of PINCH in Schwann cells and DRG neurons: shuttling and signalling after nerve injury. Glia 41, 213-223.
5. Clark, K. A., McGrall, M. and Beckerle, M. C. (2003). Analysis of PINCH function in Drosophila demonstrates its requirement in integrin-dependent cellular processes. Development 130, 2611-2621.
6. Delcommenne, M., Tan, C., Gray, V., Rue, L., Woodgett, J. and Dedhar, S. (1998). Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc. Natl. Acad. Sci. USA 95, 11211-11216.
7. Fässler, R. and Meyer, M. (1995). Consequences of lack of β1 integrin gene expression in mice. Genes Dev. 9, 1896-1908.
8. Fässler, R., Pfaff, M., Murphy, J., Noegel, A., Johansson, S., Timpl, R. and Albrecht, R. (1995). Lack of β1 integrin gene in embryonic stem cells affects morphology, adhesion and migration but not integration into the inner cell mass of blastocysts. J. Cell Biol. 128, 979-988.
9. Feng, J., Park, J., Cron, P., Hess, D. and Hemmings, B. A. (2004). Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J. Biol. Chem. 279, 41189-41196.
10. Frisch, S. M. and Ruoslahti, E. (1997). Integrins and anoikis. Curr. Opin. Cell Biol. 9, 701-706.
11. Fukuda, T., Chen, K., Shi, X. and Wu, C. (2003). PINCH-1 is an obligate partner of integrin linked kinase (ILK) functioning in cell shape modulation, motility and survival. J. Biol. Chem. 278, 51324-51333.
12. Grashoff, C., Thievessen, I., Lorenz, K., Ussar, S. and Fässler, R. (2004). Integrin-linked kinase: integrin's mysterious partner. Curr. Opin. Cell Biol. 16, 565-571.
13. Hobert, O., Moerman, D. G., Clark, K. A., Beckerle, M. C. and Ruvkun, G. (1999). A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J. Cell Biol. 144, 45-57.
14. Kadrmas, J. L. and Beckerle, M. C. (2004). The LIM domain: from the cytoskeleton to the nucleus. Nat. Rev. Mol. Cell Biol. 5, 920-931.
15. Lawlor, M. A. and Alessi, D. R. (2001). PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J. Cell Sci. 114, 2903-2910.
16. Li, S., Harrison, D., Carbonetto, S., Fässler, R., Smyth, N., Edgar, D. and Yurchenco, P. D. (2002). Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation. J. Cell Biol. 157, 1279-1290.
17. Mackinnon, A. C., Qadota, H., Norman, K. R., Moerman, D. G. and Williams, B. D. (2001). C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes. Nat. Rev. Mol. Cell Biol. 12, 787-797.
18. Novak, A., Hsu, S. C., Leung-Hagesteijn, C., Radeva, G., Papkoff, J., Montesano, R., Roskelley, C., Grosschedl, R. and Dedhar, S. (1998). Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signalling pathways. Proc. Natl. Acad. Sci. USA 95, 4374-4379.
19. Pfeifer, A., Kessler, T., Silletti, S., Cheresh, D. A. and Verma, I. M. (2000). Suppression of angiogenesis by lentiviral delivery of PEX, a noncatalytic fragment of matrix metalloproteinase 2. Proc. Natl. Acad. Sci. USA 97, 12227-12232.
20. Sakai, T., Li, S., Docheva, D., Grashoff, C., Sakai, K., Kostka, G., Braun, A., Pfeifer, A., Yurchenco, P D. and Fässler, R. (2003). Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev. 17, 926-940.
21. Tan, C., Costello, P., Sanghera, J., Dominguez, D., Baulida, J., de Herreros, A. G. and Dedhar, S. (2001). Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells. Oncogene 20, 133-140.
22. Tu, Y., Li, F. and Wu, C. (1998). Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signalling pathways. Mol. Biol. Cell. 9, 3367-3382.
23. Tu, Y., Li, F., Goicoechea, S. and Wu, C. (1999). The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. Mol. Cell Biol. 19, 2425-2434.
24. Wu, C. (1999). Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats. J. Cell Sci. 112, 4485-4489.
25. Zervas, C. G., Gregory, S. L. and Brown, N. H. (2001). Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane. J. Cell Biol. 152, 1007-1018.
26. Zhang, Y., Chen, K., Guo, L. and Wu, C. (2002a). Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration. J. Biol. Chem. 277, 38328-38338.
27. Zhang, Y., Guo, L., Chen, K. and Wu, C. (2002b). A critical role of the PINCH-integrin-linked kinase interaction in the regulation of cell shape change and migration. J. Biol. Chem. 277, 318-326.
28. Zhang, Y., Chen, K., Tu, Y., Velyvis, A., Yang, Y., Qin, J. and Wu, C. (2002c). Assembly of the PINCH-ILK-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. J. Cell Sci. 115, 4777-4786.