Circadian variation in stroke onset: Identical temporal pattern in ischemic and hemorrhagic events

Chronobiology International

Volumn 22, Issue 3, 2005, Pages 417-453

  Manfredini, Roberto ^a   Boari, Benedetta ^a   Smolensky, Michael H ^b   Salmi, Raffaella ^a   La Cecilia, Olga ^a   Malagoni, Anna Maria ^a   Haus, Erhard ^c   Manfredini, Fabio ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Blood Coagulation; Blood Pressure; Chronobiology; Circadian Rhythm; Cronotherapy; Emotional Stress; Fibrinolysis; Hemorrhagic Stroke; Ischemic Stroke; Physical Activity

Indexed keywords

BLOOD PRESSURE REGULATION; BLOOD VESSEL TONE; BODY POSTURE; CHRONOLOGY; CHRONOTHERAPY; CIRCADIAN RHYTHM; EMOTIONAL STRESS; FIBRINOLYSIS; HEMOSTASIS; HUMAN; HYPERTENSION; INCIDENCE; PHYSICAL ACTIVITY; PLASMA VISCOSITY; REVIEW; RISK ASSESSMENT; RISK MANAGEMENT; STROKE;

BLOOD COAGULATION; BLOOD PRESSURE; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; CEREBROVASCULAR ACCIDENT; CIRCADIAN RHYTHM; FIBRINOLYSIS; HUMANS; MOTOR ACTIVITY; PHARMACEUTICAL PREPARATIONS; SLEEP; STRESS, PSYCHOLOGICAL; TIME FACTORS;

EID: 23744468285     PISSN: 07420528     EISSN: None     Source Type: Journal    
DOI: 10.1081/CBI-200062927     Document Type: Review

References (232)

1. Adams, H.P., Jr., Jergensen, D.D., Kassel, N.F., Sahs, A.L. (1980). Pitfalls in the recognition of subarachnoid hemorrhage. JAMA 244:794-796.
2. Adams, H.P., Jr., Kappele, L.J., Biller, J., Gordon, D.L., Love, B.B., Gomez, F., Heffner, M. (1995). Ischemic stroke in young adults experience of 329 patients enrolled in the Iowa Registry of Stroke in Young Adults. Arch. Neurol. 52:491-495.
3. Adams, H.P., del Zoppo, G.J., von Kummer, R. (1998). Management of Stroke: A Practical Guide for the Prevention, Evaluation and Treatment of Acute Stroke. Caddo, OK, USA: Professional Communication, Inc. First Edition.
4. Ahmed, N., de la Torre, B., Wahlgren, N.G. (2004). Salivary cortisol, a biological marker of stress, is positively associated with 24-hour systolic blood pressure in patients with acute ischemic stroke. Cerebrovac. Dis. 18:206-213.
5. Ameriso, S.F., Mohler, J.G., Suarez, M., Fischer, M. (1994). Morning reduction of cerebral vasomotor reactivity. Neurology 44:1907-1909.
6. Anderson, N., Feigin, V., Bennett, D., Broad, J., Pledger, M., Anderson, C., Bonita, R. (2004). Diurnal, weekly, and seasonal variations in stroke occurrence in a population-based study in Auckland, New Zealand. New Zealand Med. J. 117:U1078.
7. Andreotti, F., Kluft, C. (1991). Circadian variation of fibrinolytic activity in blood. Chronobiol. Int. 8: 336-351.
8. Andreotti, F., Davies, G.J., Hackett, D.R., Kahn, M.I., De Bart, A.C.W., Haber, W.R., Maseri, A., Kluft, C. (1988). Major circadian fluctuations in fibrinolytic factors and possible relevance to time of onset of myocardial infarction, sudden death and stroke. Am. J. Cardiol. 62:635-637.
9. Andrews, N. P., Goldstein, D.S., Quyyumi, A.A. (1999). Effect of systemic alpha-2 adrenergic blockade on the morning increase in platelet aggregation in normal subjects. Am. J. Cardiol. 84:316-320.
10. Angleton, P., Chandler, W.L., Schmer, G. (1990). Diurnal variation in tissue-type plasminogen activator and its rapid inhibitor (PAI-1). Circulation 79:101-106.
11. Anlar, O., Tombul, T., Unal, O., Kayan, M. (2002). Seasonal environmental temperature variation in the occurrence of ischemic strokes and intracerebral hemorrhages in a Turkish adult population. Int. J. Neurosci. 112:959-963.
12. Arntz, H.R., Willich, S.N., Schreiber, C., Bruggermann, T., Stern, R., Schulthesis, H.P. (2000). Diurnal, weekly and seasonal variation of sudden cardiac death Population-based analysis of 24,061 consecutive cases. Eur. Heart. J. 21:315-320.
13. Arntz, H.R., Muller-Nordhorn, J., Willich, S.N. (2001). Cold Monday mornings prove dangerous: epidemiology of sudden cardiac death. Curr. Opin. Crit. Care 7:139-144.
14. Awtry, E.H., Loscalzo, J. (2000). Cardiovascular drugs. Circulation 101:1206-1218.
15. Baumgart, P. (1991). Circadian rhythm of blood pressure: internal and external time triggers. Chronobiol. Int. 8:444-450.
16. Beard, C.M., Fuster, V., Elveback, L.R. (1982). Daily and seasonal variation in sudden cardiac death. Mayo Clinic Proc. 57:704-706.
17. Bianchi, S., Bigazzi, R., Baldari, G., Sgherri, G., Campese, V.M. (1994). Diurnal variation of blood pressure and microalbuminuria in essential hypertension. Am. J. Hypertens. 7:23-29.
18. Bianchi, S., Bigazzi, R., Campese, V.M. (1997). Altered circadian blood pressure profile and renal damage. Blood Press. Monitor. 6:339-346.
19. Bleske, B.E., Welage, L.S., Warren, E.W., Brown, M.B., Shea, M.J. (1995). Variations in prothrombin time and international normalized ratio over 24 hours in warfarin-treated patients. Pharmacotherapy 15:709-712.
20. Brezmski, D.A., Tofler, G.H., Muller, J.E., Pohjola-Sintonen, S., Willich, S.N., Schafer, A.I., Czeisler, C.A., Williams, G.H. (1988). Morning increase in platelet aggregability. Association with assumption of the upright posture. Circulation 78:35-40.
21. Broderick, J., Brott, T., Tomsick, T., Leach, A. (1993). Lobar hemorrhage in the elderly. The undiminishing importance of hypertension. Stroke 24:49-51.
22. Bursztyn, M., Mekler, J., Wachtel, N., Ben-Ishay, D. (1994). The siesta and ambulatory blood pressure monitoring: comparability of the afternoon nap and the night sleep. Am. J. Hypertens. 7:217-221.
23. Bursztyn, M., Ginsberg, G., Hammermann-Rozemberg, R., Stessmann, J. (1999). The siesta in the elderly. Risk factor for mortality? Arch. Intern. Med. 159:1582-1586.
24. Casetta, I., Granieri, E., Fallica, E., la Cecilia, O., Paolino, E., Manfredini, R. (2002a). Patient demographic and clinical features and circadian variation in onset of ischemic stroke. Arch. Neurol. 59:48-53.
25. Casetta, I., Granieri, E., Portaluppi, F., Manfredini, R. (2002b). Circadian variability in hemorrhagic stroke. JAMA 287:1266-1267.
26. Cerrato, P., Grasso, M., Imperiale, D., Priano, L., Baima, C., Giraudo, M., Rizzuto, A., Azzaro, C., Lentini, A., Bergamasco, B. (2004). Stroke in young patients: etiopathogenesis and risk factors in different age classes. Cerebiovasc. Dis. 18:154-159.
27. Chonan, K., Hashimoto, J., Ohkubo, T., Tsuji, I., Nagai, K., Kikuya, M., Hozawa, A., Maatsubara, M., Suzuki, M., Fujiwara, T., Araki, T., Satoh, H., Hisamichi, S., Imai, Y. (2002). Insufficient duration of action of antihypertensive drugs mediates high blood pressure in the morning in hypertensive population: the Ohasama study. Clin. Exper. Hypertens. 24:261-275.
28. Coccagna, G., Mantovani, M., Brignani, F., Manzini, A., Lugaresi, E. (1971). Laboratory note. Arterial pressure changes during spontaneous sleep in man. Electroencephalogr. Clin. Neurophysiol. 31: 277-281.
29. Cohen, M.C., Rohtla, K.M., Lavery, C.M., Muller, J.E., Mittleman, M.A. (1997). Meta-analysis of the morning excess of acute myocardial infarction and sudden cardiac death. Am. J. Cardiol. 79: 1512-1516.
30. Conchonnet, Ph., Decousus, H., Boissier, C., Perpoint, B., Raynaud, J., Mismetti, P., Tardy, B., Queneau, P. (1990). Morning hypercoagulability in man. Annu. Rev. Chronopharmacol. 7:165-168.
31. Cornelissen, G., Haus, E., Halberg, F. (1992). Blood pressure assessmment from womb to tomb. In: Touitou, Y., Haus, E., eds. Biologic Rhythms in Clinical and Laboratory Medicine. Heidelberg: Springer Verlag, pp. 428-452.
32. Craven, A., Colombo, L., Cristina, M., Coloru, M. (1991). Changes in morning platelet aggregation in patients with peripheral obliterating arteriopathy after administration of picotamide. Clin. Ther. 136:23-29.
33. Deanfield, J.E., Shea, M., Kensett, M., Horlock, P., Wilson, R.A., de Landsheere, C.M., Selwyn, A.P. (1984). Silent myocardial inschaemia due to mental stress. Lancet ii:1001-1005.
34. Decousus, H. (1992). Chronobiology in hemostasis. In: Touitou, Y., Haus, E., eds. Biologic Rhythms in Clinical and Laboratory Medicine. Heidelberg: Springer Verlag, pp. 555-565.
35. Decousus, H., Croze, M., Levi, F., Perpoint, B., Jaubert, J., Bonadona, J.F., Reinberg, A., Queneanu, P. (1985). Circadian changes in anticoagulant effect of heparin infused at a constant rate. Br. Med. J. 290:341-344.
36. Decousus, H., Scully, M.F., Reynaud, J. (1987). Circadian changes in anticoagulant effect of heparin given by subcutaneous bolus. Thromb. Haemost. 58:1376.
37. Del Rosso, G., Amoroso, L., Santoferrara, A., Fiederling, B., Di Liberato, L., Albertazzi, A. (1994). Impaired blood pressure nocturnal decline and target organ damage in chronic renal failure (abstract). J. Hypertens. 12(Suppl.3):S15.
38. Dickinson, C.J. (2001). Why are strokes related to hypertension? Classic studies and hypotheses revisited. J. Hypertens. 19:1515-1521.
39. Dumont, C. (1985). Shiftwork in Asian developing countries: an overview. In: International Labour Office. In Shiftwork and Related Issues in Asian Countries. Geneva: ILO Publications, pp. 24-42.
40. Eastman, C.I., Martin, S.K. (1999). How to use light and dark to produce arcadian adaptation to night shift work. Ann. Med. 31:87-89.
41. Ehrly, A.M., Jung, G. (1973). Circadian rhythm of human blood viscosity. Biorheology 10:577-583.
42. Elliott, W.J. (1998). Circadian variation in the timing of stroke onset: a meta-analysis. Stroke 29: 992-996.
43. Elliott, W.J. (2001). Cyclic and circadian variations in cardiovascular events. Am. J. Hypertens. 14(9Pt2): 291S-295S.
44. Erren, T.C., Rieter, R.J., Finger, A., Piekavaski, C., Erren, M. (2004). What light tells man about biologic time. Med. Hypotheses 63:1074-1080.
45. Fischer, F.M., Rotenberg, L., de Castro Moreno, C.R. (2004). Equity and working time: a challenge to achieve. Chronobiol. Int. 21:813-844.
46. Fisher, C.M. (1982). Lacunar strokes and infarcts: a review. Neurology 32:871-876.
47. Franceschini, R., Gandolfo, C., Cataldi, A., Del Sette, M., Rolandi, A., Corsini, G., Rolandi, E., Barreca, T. (2001). Twenty-four-hour endothelin-1 secretory pattern in stroke patients. Biomed. Pharmacother. 55:272-276.
48. Fujita, M., Franklin, D. (1987). Diurnal changes of coronary blood flow in conscious dogs. Circulation 76:488-491.
49. Fujita, M., Araie, E., Yamanishi, K., Miwa, K., Kida, M., Nakajima, H. (1993). Circadian variation in the success rate of intracoronary thrombolysis for acute myocardial infarction. Am. J. Cardiol. 71: 1369-1371.
50. Fuster, V., Badimon, L., Cherebro, J.H. (1992). The pathogenesis of coronary artery disease and the acute coronary syndromes. N. Engl. J. Med. 326:310-318.
51. Gallerani, M., Manfredini, R., Ricci, L., Grandi, E., Cappato, R., Calò, G., Pareschi, P.L., Fersini, C. (1992). Sudden death from pulmonary thromboembolism: chronobiological aspects. Eur. Heart. J. 13:661-665.
52. Gallerani, M., Manfredini, R., Ricci, L., Cocurullo, A., Goldoni, C., Bigoni, M., Fersini, C. (1993). Chronobiological aspects of acute cerebrovascular diseases. Acta. Neurol. Scand. 87:482-487.
53. Gallerani, M., Trapella, G., Manfredini, R., Pasin, M., Napolitano, M., Migliore, A. (1994). Acute intracerebral hemorrhage: circadian and circannual patterns of onset. Acta Neurol. Scand. 89:280-286.
54. Gallerani, M., Portaluppi, F., Maida, G., Chieregato, A., Calzolari, F., Trapella, G., Manfredini, R. (1996). Circadian and circannual rhythmicity in the occurrence of subarachnoid hemorrhage. Stroke 27:1793-1797.
55. Classer, S.P., Neutel, J.M., Gana, T.J., Albert, K.S. (2003). Efficacy and safety of a once daily graded-release dildazem formulation in essential hypertension. Am. J. Hypertens. 16:51-58.
56. Gordon, R.D., Wolfe, R.K., Island, D.P., Liddle, G.W. (1966). A diurnal rhythm in plasma renin activity in man. J. Clin. Invest. 45:1587-1592.
57. Gorelick, P.B. (2004). Epidemiology of transient ischemic attack and ischemic stroke in patients with underlying cardiovascular disease. Clin. Cardiol. 27(5 Suppl 2):II4-11.
58. Gottdiener, J.S., Kop, W.J., Hausner, E., McCeney, M.K., Herrington, D., Krantz, D.S. (2003). Effects of mental stress on flow-mediated brachial arterial dilation and influence of behavioral factors and hypercholesterolemia in subjects without cardiovascular disease. Am. J. Cardiol. 92:687-691.
59. Grignani, G., Soffiantino, F., Zucchella, M., Pacchiarini, L., Tacconi, F., Bonomi, E., Pastoris, A., Sbaffi, A., Fratino, P., Tavazzi, L. (1991). Platelet activation by emotional stress in patients with coronary artery disease. Circulation 83(4 suppl.):II128-136.
60. Gruska, M., Gaul, G.B., Winkler, M., Levnaic, S., Reiter, C., Voracek, M., Kaff, A. (2005). Increased occurrence of out-of-hospital cardiac arrest on Mondays in a community-based study. Chronobiol. Int. 22:107-120.
61. Guy, A.Y., Bornstein, N.M. (2000). Are there any unique epidemiological and vascular risk factors for ischaemic strokes that occur in the morning hours? Eur. J. Neurol. 7:179-181.
62. Hachinski, V., Norris, J.W. (1985). The Acute Stroke. Philadelphia, PA: F A Davis Co.
63. Hannan, M.A., Rahman, M.M., Haque, A., Ahmed, H.U. (2001). Stroke: seasonal variation and association with hypertension. Bangladesh Med. Res. Coun. Bull. 27:69-78.
64. Hansson, L., Lindholm, L.H., Ekbom, T., Dahlof, B., Lanke, J., Schersten, B., Wester, P.O., Hedner, T., De Faire, U. (1999). Randomised trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 study. Lancet 354:1751-1756.
65. Haus, E. (1992). Chronobiology of circulating blood cells and platelets. In: Touitou, Y., Haus, E., eds. Biologic Rhythms in Clinical and Laboratory Medicine. Heidelberg: Springer Verlag, pp. 504-526.
66. Haus, E., Smolensky, M. (2005). Biological clocks and shiftwork: Circadian dysregulation and potential long term effects. Cancer Causes Control, (in press).
67. Haus, E., Touitou, Y. (1992). Principles of clinical chronobiology. In: Touitou, Y., Haus, E., eds. Biologic Rhythms in Clinical and Laboratory Medicine. Heidelberg: Springer Verlag, pp. 6-34.
68. Haus, E., Cusulos, M., Sackett-Lundeen, L., Swoyer, J. (1990). Circadian variations in blood coagulation parameters, alpha-antitrypsin antigen and platelet aggregation and retention in clinically healthy subjects. Chronobiol. Int. 7:203-216.
69. Hermida, R.C., Smolensky, M.H. (2004). Chronotherapy of hypertension. Curr. Opin. Nephrol. Hypertens. 13:501-505.
70. Hermida, R.C., Ayala, D.E., Iglesias, M. (2003a). Administration time-dependent influence of aspirin on blood pressure in pregnant women. Hypertension 41([part2]):651-656.
71. Hermida, R.C., Ayala, D.E., Calvo, C., López, J.E., Fernández, J.R., Mojón, A., Domínguez, M.J., Covelo, M. (2003b). Administration time-dependent effects of aspirin on blood pressure in untreated hypertensive patients. Hypertension 41:1259-1267.
72. Hermida, R.C., Calvo, C., Ayala, D.E., López, J.E., Fernández, J.R., Mojón, A., Domínguez, M.J., Covelo, M. (2003c). Variación estacional del fibrinógeno plasmático en pacientes dippers y no dippers con hipertensión arterial escencial ligera-moderada. Med. Clin. (Barc.) 121(1):6-11.
73. Ho, C.-H., Lin, M.-W., You, J.-Y., Chen, C.-C., Yu, T.-J. (2002). Variations of prothrombin time and international normalized ratio in patients treated with warfarin. Thromb. Res. 107:277-280.
74. Hodoglugil, U., Gunaydin, B., Yardim, S., Zengil, H., Smolensky, M.H. (2001). Seasonal variation in the effect of a fixed dose of heparin on activated clotting time in patients prepared for open-heart surgery. Chronobiol Int. 18:865-873.
75. Hyman, D.J., Pavlik, V.N. (2001). Characteristics of patients with uncontrolled hypertension in the United States. N. Engl. J. Med. 345:479-486.
76. Imeson, J.D., Meade, T.W., Steward, G.M. (1987). Day by day variation in fibrinolytic activity and in mortality from ischemic heart disease. Int. J. Epidemiol. 16:626-627.
77. Ingall, T. (2004). Stroke-incidence, mortality, morbidity and risk. J. Insur. Med. 36:143-152.
78. Jakovljevic, D., Salomaa, V., Sivenius, J., Tamminen, M., Sarti, C., Salmi, K., Kaarsalo, E., Narva, V., Immonen-Raiha, P., Torppa, J., Tuomilehto, J. (1996). Seasonal variation in the occurrence of stroke in a Finnish adult population. The FINMONICA stroke register. Finnish monitoring trends and determination in cardiovascular disease. Stroke 27:1774-1779.
79. Jovicic, A., Ivanisevic, V., Nikolajevic, R. (1991). Circadian variations of platelet aggregability and fibrinolytic activity in patients with ischemic stroke. Thromb. Res. 64:487-491.
80. Kanabrocki, E.L., Sothern, R.B., Bremner, W.F., Demakis, J.G., Bean, J.T., Ringelstein, J.G., Riley, C., Fabbrini, N., Crosby, T.J., Mermall, H., Third, J.L.H.C., Shirazi, P., Olwin, J.H. (1995). Weekly and yearly rhythms in plasma fibrinogen in hospitalized male military veterans. Am. J. Cardiol. 76: 628-631.
81. Kannel, W.B. (1996). Blood pressure as a cardiovascular risk factor: prevention and treatment. JAMA 275:1571-1576.
82. Kannel, W.B., Dawber, T.R., Cohen, M.E., McNamara, P.M. (1965). Vascular disease of the brain-epidemiologic aspects: the Framingham Study. Am. J. Public Health 55:1355-1366.
83. Kario, K., Pickering, T.G., Umeda, Y., Hoshide, S., Hoshide, Y., Morinari, M., Murata, M., Kuroda, T., Schwartz, J.E., Shimada, K. (2003). Morning surge in blood pressure as predictor of silent and clinical cerebrovascular disease in elderly hypertensives. A prospective study. Circulation 107: 1401-1406.
84. Kario, K., Ishikawa, J., Eguchi, K., Morinari, M., Hoshide, S., Ishikawa, S., Shimada, K. (2004). Sleep pulse pressure and awake mean pressure as independent predictors for stroke in older hypertensive patients. Am. J. Hypertens. 17(5Pt1):439-445.
85. Kelly-Hayes, M., Wolf, P.A., Kase, C.S., Brand, F.N., McGuirk, J.M., D'Agostino, R.B. (1995). Temporal patterns of stoke onset. The Framingham Study. Stroke 26:1343-1347.
86. Khan, F.A., Engstrom, G., Jerntorp, I., Pessah-Rasmussen, H., Janzon, L. (2005). Seasonal patterns of incidence and case fatality of stroke in Malmo, Sweden: the STROMA study. Neuroepidemiol. 24: 26-31.
87. Kharash, L.M., Gol'dkhammer, E.I., Abinader, E.G. (1996). The clinical aspects of thrombolytic therapy with streptokinase in myocardial infarct. Ter. Arkh. 68(12):53-57.
88. Kleinpeter, G., Schatzer, R., Bock, F. (1995). Is blood pressure really a trigger for the circadian rhythm of subarachnoid hemorrhage?. Stroke 26:1805-1810.
89. Klungel, O.H., Heckbert, S.R., Longstreth, W.T., Jr., Furberg, C.D., Kaplan, R.C., Smith, N.L., Lemaitre, R.N., Leufkens, H.G.M., de Boer, A., Psaty, B.M. (2001). Antihypertensive drug therapies and the risk of ischemic stroke. Arch. Intern. Med. 161:37-43.
90. Kofoed, K.F., Gleerup, G., Hedman, C., Winther, K. (1994). The circadian variation in fibrinolytic activity is not related to posture. Thrombo. Res. 73:447-450.
91. Kono, T., Morita, H., Nishina, T., Fujita, M., Hirota, Y., Kawamura, K., Fujiwara, A. (1996). Circadian variations of onset of acute myocardial infarction and efficacy of thrombolytic therapy. J. Am. Coll. Cardiol. 27:774-778.
92. Krantz, D.S., Kop, W.J., Gabbay, F.H., Rozanski, A., Barnard, M., Klein, J., Pardo, Y., Gottdiener, J.S. (1996). Circadian variation of ambulatory myocardial ischemia. Triggering by daily activities and evidence for an endogenous circadian component. Circulation 93:1364-1371.
93. Krantz, D.S., Sheps, D.S., Carney, R.M., Natelson, B.H. (2000). Effect of mental stress in patients with coronary artery disease: evidence and clinical implications. JAMA 283:1800-1802.
94. Krantz, D.S., Quigley, J.F., O'Callahan, M. (2001). Mental stress as a trigger of acute cardiac events: role of laboratory studies. Ital. Heart. J. 2:895-899.
95. Kriszbacher, I., Koppàn, M., Bòdis, J. (2004). Aspirin for stroke prevention taken in the evening? (letter). Stroke 35:2760-2761.
96. Krudler, J.W., De Boer, A., Van der Besselaar, A.M., Cohen, A.F., Schoemaker, H.C., Briet, E., Meinders, A.E. (1992). Diurnal rhythms in anticoagulant effect of heparin during a low dose constant rate infusion. A study in healthy volunteers. Thromb. Haemost. 68:30-32.
97. Krudler, J.W., Van der Besselaar, A.M., Van der Meer, F.J.M., Meinders, A.E., Briet, E. (1994). Diurnal changes in heparin effect during continuous constant rate infusion. A study in nine patients with venous thromboembolism. J. Int. Med. 235:411-417.
98. Kukla, C., Sander, D., Schwarze, J., Wittich, I., Klingelhöfer, J. (1998). Changes of circadian blood pressure patterns are associated with the occurrence of lacunar infarction. Arch. Neurol. 55: 683-688.
99. Kurnik, P.B. (1995). Cii-cadian variation in the efficacy of tissue-type plasminogen activator. Circulation 91:1341-1346.
100. Kurnik, P.B. (1996). Practical implications of circadian variations in thrombolytic and antithrombotic activities. Cardiol. Clin. 14:251-262.
101. Kuwajimi, I., Suzuki, Y., Shimosawa, T., Kanemaru, A., Hoshino, S., Kuramoto, K. (1992). Diminished decline in blood pressure in elderly hypertensive patients with left ventricular hypertrophy. Am. Heart J. 123:1307-1311.
102. Laaidi, K., Minier, D., Osseby, G.V., Couvreur, G., Besancenot, J.P., Moreau, T., Giroud, M. (2004). Seasonal variation in stroke incidence and the influence of the meteorological conditions. Rev. Neurol. (Fr.) 160:321-330.
103. Leblanc, R. (1987). The minor leak preceding subarachnoid hemorrhage. J. Neurosurg. 66:35-39.
104. Lemmer, B. (2001). Cardiovascular chronobiology and chronopharmacology. Importance of timing of dosing. In: White, W.B., ed. Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics. Totowa, N.J.: Humana Press Inc., pp. 255-271.
105. Li, C., Engstrom, G., Hedblad, B., Berglund, G., Janzon, L. (2005). Blood pressure control and risk of stroke. A population-based prospective cohort study. Stroke 36:725-730.
106. Lightman, S.L., James, V.H., Linsell, C., Mullen, P.E., Peart, W.S., Sever, P.S. (1981). Studies of diurnal changes in plasma rerun activity, and plasma noradrenalin, aldosterone and cortisol concentrations in man. Clin. Endocrinol. (Oxf.) 14:213-223.
107. MacMahon, S., Peto, R., Cutler, J., Collins, R., Sorlie, P., Neaton, J., Abbott, R., Godwin, J., Dyer, A., Stamler, J. (1990). Blood pressure, stroke, and coronary heart disease. Part I. Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet 335:765-774.
108. Malik, M., Camm, A.J. (1994). Heart rate variability and clinical cardiology. Br. Heart. J. 71:3-6.
109. Manfredini, R., Gallerani, M., Salmi, R., Fersini, C. (1994). Circadian rhythms and the heart: implications for chronotherapy of cardiovascular diseases. Clin. Pharmacol. Ther. 56:244-247.
110. Manfredini, R., Gallerani, M., Portaluppi, F., Salmi, R., Chierici, F., Fersini, C. (1995). Chronobiologic aspects of pulmonary thromboembolism. Int. J. Cardiol. 52:31-37.
111. Manfredini, R., Gallerani, M., Portaluppi, F., Fersini, C. (1996). Relationships of the circadian rhythms of thrombotic, ischemic, hemorrhagic, and arrhythmic events to blood pressure rhythms. Ann. N. Y. Acad. Sci. 783:141-158.
112. Manfredini, R., Gallerani, M., Portaluppi, F., Salmi, R., Fersini, C. (1997). Chronobiological patterns of onset of acute cerebrovascular diseases. Thromb. Res. 88:451-465.
113. Manfredini, R., Gallerani, M., Portaluppi, F., Salmi, R., Zamboni, P., Fersini, C. (1998). Circadian variation in the onset of acute critical limb ischemia. Thromb. Res. 92:163-168.
114. Manfredini, R., Portaluppi, F., Zamboni, P., Salmi, R., Gallerani, M. (1999). Circadian variation in spontaneous rupture of abdominal aorta. Lancet 353:643-644.
115. Manfredini, R., Casetta, I., Paolino, E., la Cecilia, O., Boari, B., Fallica, E., Granieri, E. (2001). Monday preference in onset of ischemic stroke. Am. J. Med. 111:401-403.
116. Manfredini, R., la Cecilia, O., Boari, B., Steliu, J., Michelini, V., Carli, P., Zanotti, C., Bigoni, M., Gallerani, M. (2002). Circadian pattern of emergency calls: implications for ED organization. Am. J. Emerg. Med. 20:282-286.
117. Manfredini, R., Boari, B., Gallerani, M., Salmi, R., Bossone, E., Distante, A., Eagle, K.A., Mehta, R.H. (2004). Chronobiology of rupture and dissection of aortic aneurysms. J. Vasc. Surg. 40:382-388.
118. Markmann, P., Sandstrom, B., Jespersen, J. (1993). Dietary effects on circadian fluctuation in human blood coagulation factor VII and fibrinolysis. Atherosclerosis 101:225-234.
119. Marler, J.R., Price, T.C., Clarck, G.L., Muller, J.E., Robertson, T., Mohr, J.P., Hier, D.B., Wolf, P.A., Caplan, L.R., Foulkes, M.A. (1989). Morning increase in the onset of ischemic stroke. Stroke 20: 473-476.
120. Marsh, E.R., II., Biller, J., Adams, H.P., Jr., Marler, J.R., Hubert, J.R., Love, B.B., Gordon, D.L. (1990). Circadian variation in onset of acute ischemic stroke. Arch. Neurol. 47:1178-1180.
121. Massing, W., Angermeyer, M.C. (1985). Myocardial infarction on various days of the week. Psychol. Med. 15:852-857.
122. May, M., McCarron, P., Stansfeld, S., Ben-Shlomo, Y., Gallacher, J., Yarnell, J., Davey Smith, G., Elwood, P., Ebrahim, S. (2002). Does psychological distress predict the risk of ischemic stroke and transient ischemic attack? The Caerphilly study. Stroke 33:7-12.
123. Mayberg, M.R., Batjer, H.H., Dacey, R., Diringer, M., Haley, E.C., Heros, R.C., Sternau, L.L., Torner, J., Adams, H.P., Jr., Feinberg, W. (1994). Guidelines for the management of aneurysmal subarachnoid hemorrhage. A statement for health care professionals from a special Writing Group of the Stroke Council, American Heart Association. Stroke 25:2315-2328.
124. McNamara, P., Seo, S.P., Rudic, R.D., Sehgal, A., Chakravarti, D., Fitzgerald, G.A. (2001). Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. Cell 105:877-889.
125. Meal, A.G., Pringle, M., Hammersley, V. (2000). Time changes in new cases of ischaemic heart disease in general practice. Family. Pract. 17:394-400.
126. Mehta, H.R., Manfredini, R., Hassan, F., Sechtem, U., Bossone, E., Oh, J.K., Cooper, J.V., Smith, D.E., Portaluppi, F., Penn, M., Hutchison, S., Nienaber, C.A., Isselbacher, E.M., Eagle, K.A. (2002). Chronobiological patterns of acute aortic dissection. Circulation 106:I110-1115.
127. Mehta, H.R., Manfredini, R., Bossone, E., Hutchison, S., Evangelista, A., Boari, B., Cooper, J.V., Smith, D.E., O'Gara, P.T., Gilon, D., Pape, L.A., Nienaber, C.A., Isselbacher, E.M., Eagle, K.A. (2005). Does circadian and seasonal variation in occurrence of acute aortic dissection influence in-hospital outcomes?. Chronobiol Int. 22(2):343-352.
128. Messner, T., Lundberg, V. (2003). Trends in sudden cardiac death in the northern Sweden MONICA area 1985-1999. J. Intern. Med. 253:320-328.
129. Meyers, D.G. (2003). Myocardial infarction, stroke and sudden cardiac death may be prevented by influenza vaccination. Cur. Atheroscler. Rep. 5:146-149.
130. Mittleman, M.A., Maclire, M., Nachnani, M., Sherwood, J.B., Muller, J.E. (1997). Educational attainment, anger, and the risk of triggering myocardial infarction onset. The determinants of Myocardial Infarction Onset Study Investigators. Arch. Intern. Med. 147:769-775.
131. Millar-Craig, M., Bishop, C., Raftery, E. (1978). Circadian variation of blood pressure. Lancet 1: 795-797.
132. Mismetti, P., Reynaud, J., tardy-Ponce, B., Laporte-Simitsidis, S., Scully, M., Goodwyn, C., Queneau, P., Decousus, H. (1995). Chrono- pharmacological study of once daily curative dose of a low molecular weight heparin (200 IU antiXa/kg of Dalteparin) in ten healthy volunteers. Thromb. Haemost. 74:660-666.
133. Molgaard, H., Sorensen, K.E., Bjerregaard, P. (1991). Circadian variation and influence of risk factors on heart rate variability in healthy subjects. Am. J. Cardiol. 68:777-784.
134. Morgan, T., Anderson, A., Jones, E. (1997). The effect on 24h blood pressure of an angiotensin converting enzyme inhibitor (perindopril) administered in the morning or at night. J. Hypertens. 15:205-211.
135. Mulcahy, D., Wright, C., Sparrow, J., Cunningham, D., Curcher, D., Purcell, H., Fox, K. (1993). Heart rate and blood pressure consequences of an afternoon SIESTA (Snooze Induced Excitation of Sympathetic Triggered Activity). Am. J. Cardiol. 71:611-614.
136. Muller, J.E., Stone, P.H., Turi, Z.G., Rutherford, J.D., Czeisler, C.A., Parker, C., Poole, W.K., Passamani, E., Roberts, R., Robertson, T., Sobel, B.E., Willerson, J.T., Braunwald, E. (1985). Circadian variation in the frequency of onset of acute myocardial infarction. N. Engl. J. Med. 313: 1315-1322.
137. Muller, J.E., Ludmer, P.L., Willich, S.N., Tofler, G.H., Aylmer, G., Klangos, I., Stone, P.H. (1987). Circadian variation in the frequency of sudden cardiac death. Circulation 75:131-138.
138. Natali, G., Acitelli, P., Cicogna, S., Del Re, M., Di Pietro, M., Silberkuhl, G., Spacca, G., Trotta, A. (1982). Essential hypertension: chronobiological study of the circadian variations in the urinary excretion of free catecholamines. Chronobiologia 9:99-102.
139. Nebel, L.E., Howell, R.H., Krantz, D.S., Falconer, J.J., Gottdiener, J.S., Gabbay, F.H. (1996). The circadian variation of cardiovascular stress levels and reactivity: relationship to individual changes in morningness/eveningness. Psychophysiol. 33:273-281.
140. Nguyen-Huynh, M.N., Johnston, S.C. (2005). Transient ischemic attack: a neurologic emergency. Curr. Neurol. Neurosci. Rep. 5:13-20.
141. Nicolau, G.Y., Haus, E., Popescu, M., Sackett-Lundeen, L., Petrescu, E. (1991). Circadian, weekly, and seasonal variations in cardiac mortality, blood pressure, and catecholamine excretion. Chronobiol. Int. 8:149-159.
142. Nyquist, P.A., Brown, R.D., Jr., Wiebers, D.O., Crowson, C.S., O'Fallon, W.M. (2001). Circadian and seasonal occurrence of subarachnoid and intracerebral hemorrhage. Neurol. 56:190-193.
143. O'Brien, E., Sheridan, J., O'Malley, K. (1988). Dippers and nondippers. Lancet 2:397.
144. O'Brien, A.A., Rajkumar, C., Bulpitt, C.J. (1999). Blood pressure lowering for the primary and secondary prevention of stroke: treatment of hypertension reduces the risk of stroke. J. Cardiovasc. Risk 6: 203-205.
145. Oberg, A.L., Ferguson, J.A., McIntyre, L.M., Horner, R.D. (2000). Incidence of stroke and season of the year: evidence of an association. Am. J. Epidemiol. 152:558-564.
146. Ogata, T., Kimura, K., Minematsu, K., Kazui, S., Yamaguchi, T. (2004). Japan multicenter stroke investigators' collaboration. Variation in ischemic stroke frequency in Japan by season and by other variables. J. Neurol. Sci. 225:85-89.
147. Ohkubo, T., Hozawa, A., Nagai, K., Kikuya, M., Tsuji, I., Ito, S., Satoh, H., Hisamichi, S., Imai, Y. (2000). Prediction of stroke by ambulatory blood pressure monitoring versus screening blood pressure measurements in a general population: the Osahama study. J. Hypertens. 18:847-854.
148. Ohlson, C.G., Bodin, L., Bryngelsson, I.L., Helsing, M., Malmberg, L. Winter weather conditions and myocardial infarct. Scand. J. Social Med. 1991, 19:20-25.
149. Otto, M.E., Svatikova, A., Barretto, R.B., Santos, S., Hoffmann, M., Khanderia, B., Somers, V., Early morning attenuation of endothelial function in healthy humans. Circulation 2004, 109: 2507-2510.
150. Palatini, P., Penzo, M., Racioppa, A., Zugno, E., Guzzardi, G., Anaclerio, M., Pessina, A.C. (1992). Clinical relevance of nighttime blood pressure and of daytime blood pressure variance. Arch. Intern. Med. 152:1855-1860.
151. Panza, J.A., Epstein, S.E., Quyyumi, A.A. (1991). Circadian variation in vascular tone and its relation to alpha-sympathetic vasoconstrictor activity. N. Engl. J. Med. 325:986-990.
152. Peters, R.W. (1996). Circadian patterns and triggers of sudden cardiac death. Cardiol. Clin. 14: 185-194.
153. Petralito, A., Mangiafico, R.A., Gibiino, S., Cuffari, M.A., Miano, M.F., Fiore, C.E. (1982). Daily modifications of plasma fibrinogen, platelets aggregation, Howell's time, PTT, TT, and antithrombin III in normal subjects and in patients with vascular disease. Chronobiologia 9:195-201.
154. Phillips, R.A., Sheinart, K.F., Godbold, J.H., Mahboob, R., Tuhrin, S. (2000). The association of blunted nocturnal blood pressure dip and stroke in a multiethnic population. Am. J. Hypertens. 13:1250-1255.
155. Portaluppi, F., Smolensky, M.H. (2001). Circadian rhythm and environmental determinants of blood pressure regulation and hypertensive conditions. In: While, W.B., ed. Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics. Totwa, N.J.: Humana Press Inc., pp. 79-138.
156. Portaluppi, F., Vergnani, L., Manfredini, R., Fersini, C. (1996). Endocrine mechanisms of blood pressure regulation. Ann. N.Y. Acad. Sci. 783:113-131.
157. Pringle, E., Phillips, C., Thijs, L., Davidson, C., Staessen, J.A., de Leeuw, P.W., Jaaskivi, M., Nachev, C., Parati, G., O'Brien, E.T., Tuomilehto, J., Webster, J., Bulpitt, C.J., Fagard, R.H. (2003). Systolic blood pressure variability as a risk factor for stroke and cardiovascular mortality in the elderly hypertensive population. J. Hypertens. 21:2251-2257.
158. Prisant, L.M., Devane, J.G., Butler, J. (2000). A steady state evaluation of the bioavailability of chronotherapeutic oral drug absorption system verapamil PM after nighttime dosing versus immediate-acting verapamil dosed every eight hours. Am. J. Ther. 7:345-251.
159. Prisant, L.M., Weber, M., Black, H.R. (2003). The Role of circadian rhythm in cardiovascular function - Efficacy of a chronotherapeutic approach to controlling hypertension with Veralan PM (verapamil HCL). Today's Therapeutic Trends 21:201-213.
160. Quyyumi, A.A., Panza, J.A., Diodati, J.G., Lakatos, E., Epstein, S.E. (1992). Orcadian variation in ischemic threshold. A mechanism underlying the circadian variation in ischemic events. Circulation 86:22-28.
161. Rabkin, S.W., Mathewson, F.A., Tate, R.B. (1980). Chronobiology of cardiac sudden death. JAMA 244: 1357-1358.
162. Ramirez-Lassepas, M., Haus, E., Lakatua, D.J., Sackett, L., Swoyer, J. (1980). Seasonal (circannual) periodicity of spontaneous intracerebral hemorrhage in Minnesota. Ann. of Neurology 8:539-541.
163. Rashid, P., Leonardi-Bee, J., Bath, P. (2003). Blood pressure reduction and secondary prevention of stroke and other vascular events. Stroke 34:2741-2748.
164. Redfern, P., ed. (2003). Chronotheapeutics. London: Pharmaceutical Press.
165. Redfern, P., Lemmer, B., eds. (1997). Physiology and Pharmacology of Biological Rhythms. Heidelberg: Springer-Verlag.
166. Reinberg, A., Smolensky, M.H., eds. (1983). Biological Rhythms and Medicine. Cellular, Metabolic, Physiologic, and Pharmacologic Aspects. Heidelberg: Springer-Verlag.
167. Richards, A.M., Nicholls, M.G., Espiner, E.A., Ikram, H., Cullens, M., Hinton, D. (1986). Diurnal patterns in blood pressure, heart rate and vasoactive hormones in normal man. Clin. Exp. Hypertens. 8:153-156.
168. Ridker, P.M., Manson, J.E., Buring, J.E., Hennekens, C.H. (1990). Circadian variation of acute myocardial infarction and the effect of low-dose aspirin in a randomized trial of physicians. Circulation 82:897-902.
169. Rizzoni, D., Muiesan, M.L., Montani, G., Zulu, R., Calebich, S., Agabiti-Rosei, E. (1992). Relationship between initial cardiovascular structural changes and daytime and nighttime blood pressure monitoring. Am. J. Hypertens. 5:180-186.
170. Rosing, D.R., Brakman, P., Redwood, D.R., Goldstein, R.E., Beiser, G.D., Astrup, T., Epstein, S.E. (1970). Blood fibrinolytic activity in man: diurnal variation and the response to varying intensities of exercise. Circ. Res. 27:171-184.
171. Rothwell, P.M., Coull, A.J., Giles, M.F., Howard, S.C., Silver, L.E., Bull, L.M., Gutnikov, S.A., Edwards, P., Mant, D., Sackley, C.M., Farmer, A., Sandercock, P.A., Dennis, M.S., Warlow, C.P., Bamford, J.M., Anslow, P. (2004). Oxford Vascular Study Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study). Lancet 12:1925-1933.
172. Sander, D., Winbeck, K., Klingelhöfer, J., Conrad, B. (2000). Extent of cerebral white matter lesions is related to changes of circadian blood pressure rhythmicity. Arch. Neurol. 57:1302-1307.
173. Schoenhard, J.A., Smith, L.H., Painter, C.A., Eren, M., Johnson, C.H., Vanghan, D.E. (2003). Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL-1 and BMAL-2. J. Molecul. Cell. Cardiol. 35:473-481.
174. SHEP Cooperative Research Group. (1991). Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. JAMA, 265:3255-3264.
175. Shimada, K., Kawamoto, A., Matsubayashi, K., Ozawa, T. (1990). Silent cerebrovascular disease in the elderly. Correlation with ambulatory pressure. Hypertension 16:692-699.
176. Shimada, K., Kawamoto, A., Matsubayashi, K., Nishinaga, M., Kimura, S., Ozawa, T. (1992). Diurnal blood pressure variations and silent cerebrovascular damage in elderly patients with hypertension. J. Hypertens. 10:875-878.
177. Sica, D.A., Wilson, D.K. (2001). Sodium, potassium, the sympathetic nervous system, and the renin-angiotensin system. In: White, W.B., ed. Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics. Totowa, N.J.: Humana Press Inc., pp. 171-189.
178. Sica, D.A., Neutel, J.M., Weber, M., Manowitz, N. (2004). The antihypertensive efficacy and safety of a chronotherapeutic formulation of propranolol in patients with hypertension. J. Clin. Hypertens. 6: 231-241.
179. Smith, D.H.G., Neutel, J.M., Weber, M.A. (2001). A new chronotherapeutic oral drug absorption system for verapamil optimizes blood pressure control in the morning. Am. J. Hypertens. 14:14-19.
180. Singh, R.B., Kartik, C., Otsuka, K., Pella, D., Pella, J. (2002). Brain-heart connection and the risk of heart attack. Biomed. Pharmacother. 56:257-265.
181. Smolensky, M.H. (1983). Aspects of human chronopathology. In: Reinberg, A., Smolensky, M.H., eds. Biological rhythms and medicine. Cellular, Metabolic, Physiologic, and Pharmacologic Aspects. Heidelberg: Springer Verlag, pp. 131-209.
182. Smolensky, M.H. (2002). Compliance to prescription medication entails respect for treatment timing (Ltr). Chronobiol. Int. 19:502-505.
183. Smolensky, M.H., Tatar, S.E., Bergman, S.A., Losman, J.G., Barnard, C.N., Dacso, C.C., Kraft, I.A. (1977). Circadiari rhythmic aspects of cardiovascular function. A review by chronobiologic statistical methods. Chronobiologia 3:337-371.
184. Smolensky, M.H., Hermida, R.C., Portaluppi, F., Haus, E., Reinberg, A. (2005). Chronotherapeutics in the treatment of hypertension. In: Oparil, S., Weber, M., eds. Hypertension: A Companion to Brenner and Rector's The Kidney, 2nd Ed. Philadelphia: Elsevier-Saunders, pp. 530-542.
185. Somers, V.K., Dyken, M.E., Mark, A.L., Abboud, F.M. (1993). Sympathetic nerve activity during sleep in normal subjects. N. Engl. J. Med. 328:303-307.
186. Soulban, G., Labrecque, G., Barbeau, G. (1995). Time-dependent variations in the coagulation Factors II, VII, IX, and X in young and elderly volunteers. Chronobiol. Int. 12:206-213.
187. Sowers, J.R., Stren, N., Nyby, M.D., Jasberg, K.A. (1982). Dopaminergic regulation of circadian rhythms of blood pressure, renin and aldosterone in essential hypertension. Cardiovasc. Res. 16: 317-323.
188. Spengos, K., Vemmos, K., Tsivgoulis, G., Manios, E., Zakopoulos, N., Mavrikakis, M., Vassilopoulos, D. (2003). Diurnal and seasonal variation of stroke incidence in patients with cardioembolic stroke to atrial fibrillation. Neuroepidemiol. 22:204-210.
189. Spielberg, C., Falkenhahn, D., Willich, S.N., Wegscheider, K., Voller, H. (1996). Circadian, day-of-week, and seasonal variability in myocardial infarction: comparison between working and retired patients. Am. Heart. J. 132:579-585.
190. Stephenson, L.A., Kolka, M.A., Francesconi, R., Gonzalez, R.R. (1989). Circadian variations in plasma rennin activity, catecholamines and aldosterone during exercise in women. Eur. J. Appl. Physiol. Occup. Physiol. 58:756-764.
191. Stergiou, G.S., Vemmos, K.N., Pliarchoupolou, K.M., Synetos, A.G., Roussias, L.G., Mountokalakis, T.D. (2002). Parallel morning and evening surge in stroke onset, blood pressure, and physical activity. Stroke 33:1480-1486.
192. Stone, P.H. (1990). Triggers of transient myocardial ischemia: circadian variation and relation to plaque rupture and thrombosis in stable coronary artery disease. Am. J. Cardiol. 66:32G-36G.
193. Strandgaard, S. (1978). Autoregulation of cerebral circulation in hypertension. Acta. Neurol. Scand. 57(suppl.66):1-82.
194. Strandgaard, S., Paulson, O.B. (1994). Cerebrovascular consequences of hypertension. Lancet 344: 519-521.
195. Strike, P.C., Steptoe, A. (2003). New insights into the mechanisms of temporal variation in the incidence of acute coronary syndromes. Clin. Cardiol. 26:495-499.
196. Szapary, L., Horvath, B., Marton, Z., Alexy, T., Demeter, N., Szots, M., Klabuzai, A., Kesmarky, G., Juricskay, I., Gaal, V., Czopf, J., Toth, K. (2004). Hemorheological disturbances in patients with chronic cerebrovascular diseases. Clin. Hemorheol. Microcirc. 31:1-9.
197. Taylor, T.N., Davis, P.H., Torner, J.C., Holmes, J., Meyer, J.W., Jacobson, M.F. (1996). Lifetime cost of stroke in the United States. Stroke 27:1459-1466.
198. Timio, M., Lolli, S., Verdura, C., Monarca, C., Merante, F., Guerrini, E. (1993). Circadian blood pressure changes in patients with chronic renal insufficiency: a prospective study. Renal Failure 35:233-237.
199. Thorvaldsen, P., Asplund, K., Kuulasmaa, K., Rajakangas, A.M., Schroll, M. for the WHO MONICA Project. (1995). Stroke incidence, case fatality, and mortality in the WHO MONICA Project. Stroke 26:361-367.
200. Thrift, A.G., Donnan, G.A., McNeill, J.J. (1995). Epidemiology of intracerebral hemorrhage. Epidemiol. Rev. 17:361-381.
201. Tofler, G.H., Stone, P.H., Maclure, M., Edelman, E., Davis, V.G., Robertson, T., Antman, E.M., Muller, J.E. (1990). Analysis of possible triggers of acute myocardial infarction (The MILIS Study). Am. J. Cardiol. 66:22-27.
202. Toni, D., Argentino, C., Gentile, M., Sacchetti, M.L., Girmenia, F., Millefiorini, E., Fieschi, C. (1991). Circadian variation in the onset of acute cerebral ischemia: ethiopathogenetic correlates in 80 patients given angiography. Chronobiol. Int. 8:321-326.
203. Touitou, Y., Haus, E., eds. (1992). Biologic Rhythms in Clinical and Laboratory Medicine. Heidelberg: Springer Verlag.
204. Touitou, Y., Touitou, C., Bogdan, A., Reinberg, A., Auzeby, A., Beck, H., Guillet, P. (1986). Differences between young and elderly subjects in seasonal and circadian variations of total plasma proteins and blood volume as reflected by hemoglobin, hematocrit, and erythrocyte count. Clin. Chem. 32: 801-804.
205. Truelsen, T., Nielsen, N., Boysen, G., Gronbaek, M. for the Copenhagen City Heart Study. (2003). Self-reported stress and risk of stroke: the Copenhagen City Heart Study. Stroke 34:856-862.
206. Turton, M.B., Degan, T. (1974). Circadian variations of plasma catecholamines, cortisol, and immunoreactive insulin concentration in supine subjects. Clin. Chim. Acta 55:389-397.
207. Ueyama, T., Seriba, E., Kasamatsu, K., Hano, T., Yamamato, K., Nishio, I., Tsuruo, Y., Yoshida, K. (2003). Molecular mechanisms of emotional stress-induced and catecholamine-induced heart attack. J. Cardiovasc. Pharmacol. 41(suppl.1):S115-118.
208. Undar, L., Turkay, C., Korkmaz, L. (1989). Circadian variation in circulating platelet aggregates. Ann. Med. 21:429-433.
209. Vagaonescu, T.D., Phillips, R.A., Tuhrim, S. (2001). Seasonal, weekly, and circadian variability of ischemic and hemorrgagic stroke. In: White, W.B., ed. Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics. Totowa, N.J.: Humana Press Inc., pp. 243-252.
210. Vagnucci, A.H., McDonald, R.H., Jr., Dash, A.L., Wong, A.K. (1974). Intradiem changes of plasma aldosterone, cortisol, corticosterone and growth hormone in sodium restriction. J. Clin. Endocrinol. Metab. 38:761-776.
211. Van der Bom, J.G., de Maat, M.P.M., Bots, M.L., Hofman, A., Kluft, C., Grobbee, D.E. (1997). Seasonal variation in fibrinogen in the Rotterdam study. Thromb. Haemost. 78:1059-1062.
212. Van Rossum, C.T., Shipley, M.J., Hemingway, H., Grobbee, D.E., Machenbach, J.P., Marmot, M.G. (2001). Seasonal variation in cause-specific mortality: are there high-risk groups? 25-year follow-up of civil servants from the first Whitehall study. Int. J. Epidemiol. 30:1109-1116.
213. Vehvilainen, A.T., Kumpusalo, E.A., Takala, J.K. (1999). They call it stormy Monday-reasons for referral from primary to secondary care according to the day of the week. Brit. J. Gen. Prac. 49: 909-911.
214. Verdecchia, P., Schillaci, G., Guerrieri, M., Gatteschi, C., Benemio, G., Boldrini, F., Pollavini, G. (1990). Circadian blood pressure changes and left ventricular hypertrophy in essential hypertension. Circulation 81:528-536.
215. Verdecchia, P., Porcellati, C., Schillaci, G., Borgioni, C., Ciucci, A., Battistelli, M., Guerrieri, M., Gatteschi, C., Zampi, I., Santucci, A., Santucci, C., Reboldi, G. (1994). Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension. Hypertension 24:793-801.
216. Violaris, A.G., Trudgill, N.J., Rowlans, L., Gunn, J., Tsikaderis, D., Campbell, S. (1994). Variable and circadian response to a fixed high dose (12,500 IU twice daily), subcutaneous heparin regimen after thrombolytic therapy for acute myocardial infarction. Coronary. Artery. Dis. 5(3):257-265.
217. Waldstein, S.R., Siegel, E.L., Lefkowitz, D., Maier, K.J., Brown, J.R., Obuchowski, A.M., Katzel, L.I. (2004). Stress-induced blood pressure reactivity and silent cerebrovascular disease. Stroke 35: 1294-1298.
218. Wang, H., Sekine, M., Chen, X., Kagamimori, S. (2002). A study of weekly and seasonal variation of stroke onset. Int. J. Biometeorol. 47:13-20.
219. Wang, Y., Levi, C.R., Attia, J.R., D'Este, C.A., Spratt, N., Fischer, J. (2003). Seasonal variation in stroke in the Hunter Region, Australia: a 5-year hospital-based study, 1995-2000. Stroke 34:1144-1150.
220. White, W.B., Anders, R.J., MacInyre, J.M., Black, H.R., Sica, D.A. (1995). Nocturnal dosing of a novel delivery system of verapamil for systemic hypertension. Am. J. Cardiol. 76:375-380.
221. White, W.B., Black, H.R., Weber, M., Elliott, W.J., Bryzinski, B., Fakouhi, T.D. (1998). Comparison of effects of controlled onset extended release verapamil at bedtime and nifedipine gastrointestinal therapeutic system on arising on early morning blood pressure, heart rate, and heart rate-blood pressure product. Am. J. Cardiol. 81:424-431.
222. White, W.B., Sica, D.A., Calhoun, D., Mansoor, G.A., Anders, R.J. (2002). Preventing increases in early-morning blood pressure, heart rate, and the rate-pressure product with controlled onset extended release verapamil at bedtime versus enalapril, losartan, and placebo in the arising. Am. Heart. J. 144:657-665.
223. Willerson, J.T., Hillis, L.D., Winniford, M., Buja, M. (1986). Speculation regarding mechanisms responsible for acute ischemic heart disease syndromes. J. Am. Coll. Cardiol. 8:245-250.
224. Willich, S.N., Klatt, S., Arntz, H.-R. (1998). Circadian variation and triggers of acute coronary syndrome. Eur. Heart. J. 19(suppl.C):C12-23.
225. Winther, K., Hillegass, W., Tofler, G.H., Jimenez, A., Brezinski, D.A., Schafer, A.I., Loscalzo, J., Williams, G.H., Muller, J.E. (1992). Effects on platelet aggregation and fibrinolytic activity during upright posture and exercise in healthy men. Am. J. Cardiol. 70:1051-1055.
226. Wolf, P., Cobb, J., D'Agostino, R. (1992). Epidemiology of stroke. In: Barnett, H.J.M., Mohr, J.P., Stein, B.M., Yatsu, F., eds. Stroke: Pathophysiology, Diagnosis and Management, 2nd ed. New York: Churchill Livingstone, pp. 3-27.
227. Woodhouse, P.R., Khaw, K.T., Plummer, M., Foley, A., Meade, T.W. (1994). Seasonal variations of plasma fibrinogen and factor VII activity in the elderly: winter infections and death from cardiovascular disease. Lancet 343:435-439.
228. Wu, G., Wu, Z., Zeng, Z., Liu, J., Wang, W., Qin, L., Liu, J., Liu, S., Zhao, D. (2002). Study on temporal patterns of stroke onset from community-based cohort in Beijing. Chung-Hau. Liu. Hsing. Ping. Usueh. Tsa. Chih. Chinese. J. Epidemiol. 23:277-280.
229. Yasue, H., Omote, S., Tazikawa, A., Nagao, M., Miwa, K., Tanaka, S. (1979). Circadian variation of exercise capacity in patients with Prinzmetal's variant angina: role of Exercise-induced coronary artery spasm. Circulation 59:938-948.
230. Yazlle Rocha, J.S., Silva, G.G. (2000). Myocardial infarction hospitalization by day of the week: retrospective study. Rev. Saude. Pub. (Brazil) 34:157-162.
231. Yip, H.-K., Chen, S.-S., Liu, J.S., Chang, H.-W., Kao, Y.-F., Lan, M.-Y., Chang, Y.-Y., Lai, S.-L., Chen, W.-H., Chen, M.-C. (2004). Serial changes in platelet activation in patients after ischemic stroke: Role of pharmacodynamic modulation. Stroke 35:1683-1687.
232. Zoble, R., Deedwania, P.C. (1997). Circadian patterns in acute myocardial infraction: The role of triggers and other modulating factors. In: Deedwania, P.C., ed. Circadian Rhythms of Cardiovascular disorders. Armonk, NY: Futura Publishing Co., Inc.