Amiloride protects against pentylenetetrazole-induced kindling in mice

British Journal of Pharmacology

Volumn 145, Issue 7, 2005, Pages 880-884

  Ali, Atif ^a   Ahmad, Farhan Jalees ^a   Pillai, Krishna Kolappa ^a   Vohora, Divya ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Amiloride; Anticonvulsant; Kindling; Pentylenetetrazole; Sodium hydrogen exchangers

Indexed keywords

AMILORIDE; DIAZEPAM; PENTETRAZOLE; SODIUM HYDROGEN EXCHANGER INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLONIC SEIZURE; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; KINDLING; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

AMILORIDE; ANIMALS; ANTICONVULSANTS; CONVULSANTS; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; KINDLING, NEUROLOGIC; MALE; MICE; PENTYLENETETRAZOLE; SEIZURES;

EID: 23744458931     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706291     Document Type: Article

References (32)

1. ALI, A., AHMAD, F.J., PILLAI, K.K. & VOHORA, D. (2004). Evidence for antiepileptic potential of amiloride with neuropharmacological benefits in rodent models of epilepsy and behaviour. Epilepsy Behav., 5, 322-328.
2. ARAM, J.A. & LODGE, D. (1987). Epileptiform activity induced by alkalosis in rat neocortical slices: block by antagonists of N-methyl-D-aspartate. Neurosci. Lett., 83, 345-350.
3. BONNET, U., BINGMANN, D. & WIEMANN, M. (2000). Intracellular pH modulates spontaneous and epileptiform bioelectric activity of hippocampal CA3-neurones. Eur. Neuropsychopharmacol., 97, 97-103.
4. BONNET, U., WIEMANN, M., BINGMANN, D. & GASTPAR, M. (1997). Transmembrane acid extrusion mechanisms: a target for neuropsychopharmacological drug design? Pharmacopsychiatry, 30, 154.
5. CHESLER, M. (1990). The regulation and modulation of pH in the nervous system. Prog. Neurobiol., 34, 401-427.
6. CHESLER, M. & KAILA, K. (1992). Modulation of pH by neuronal activity. Trends Neurosci., 15, 396-402.
7. COX, G.A., LUTZ, C.M., YANG, C.L., BEIMESDERFER, D., BRONSON, R.T., FU, A., ARONSON, P.S., NOEBELS, J.L. & FRANKEL, W.N. (1997). Sodium-hydrogen exchanger gene defect in slow-wave epilepsy mutant mice. Cell, 91, 139-148.
8. DOLLERY, C. (1999). Amiloride hydrochloride. In: Therapeutic Drugs. 2nd edn., Vol. 1, pp. A127-A129. Edinburgh: Churchill Livingstone.
9. B receptor antagonism on the development of pentylenetetrazole- induced kindling in mice. Brain Res., 809, 182-188.
10. GIFFARD, R.G., MONYER, H., CHRISTINE, C.W. & CHOI, D.W. (1990). Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures. Brain Res., 506, 339-342.
11. + exchanger. J. Membr. Biol., 90, 1-12.
12. HIGASHIMA, M., KINOSHITA, H. & KOSHINO, Y. (1998). Contribution of T-type calcium channels to after-discharge generation in rat hippocampal slices. Brain Res., 781, 129-136.
13. KRAPF, R. & ALPERN, R.J. (1993). Cell pH and transepithelial transport in the renal proximal tubule. J. Membr. Biol., 131, 1-10.
14. KUPFERBERG, H. (2001). Animal models used in the screening of antiepileptic drugs. Epilepsia, 42 (Suppl 4), 7-12.
15. LEWIN, E., PEIRS, J., BLECK, V., ZAHNISER, N.R. & HARRIS, R.A. (1989). Chemical kindling decreases GABA activated chloride channels of mouse brain. Eur. J. Pharmacol., 160, 101-106.
16. + exchange antiporter and control of intracellular pH in hippocampal brain slices. Brain Res., 73, 1108-1113.
17. LOSCHER, W. (1993). Which animal models should be used in the search for new antiepileptic drugs. Epilepsia, 34, 188.
18. + exchangers in rat central nervous system. Neuroscience, 79, 591-603.
19. MASON, C.R. & COOPER, R.M. (1972). A permanent change in convulsive threshold in normal and brain-damaged rats with repeated small doses of pentylenetetrazole. Epilepsia, 13, 663-674.
20. MCNAMARA, J.O. (1988). Pursuit of the mechanisms of kindling Trends Neurosci., 11, 32-36.
21. PUKA, N. & LEHMANN, A. (1994). In vivo acidosis reduces extracellular concentrations of taurine and glutamate in the rat hippocampus. J. Neurosci. Res., 37, 641-646.
22. ROOS, A. & BORON, W. (1981). Intracellular pH. Physiol. Rev., 61, 296-434.
23. B receptors in the pentylenetetrazole kindling model of epilepsy in mice. Neuropharmacology, 39, 2147-2161.
24. SCHRODER, H., BECKER, A. & HOLLT, V. (1998). Sensitivity and density of glutamate receptor subtypes in the hippocampal formation are altered in pentylenetetrazol-kindled rats. Exp. Brain Res., 120, 527-530.
25. SCHRODER, H., BECKER, A. & LOONER, B. (1993). Glutamate binding to brain membrane is increased in pentylenetetrazol-kindled rats. J. Neurochem., 60, 1007-1011.
26. SCHWARK, W.S. & HALUSKA, M. (1987). Prophylaxis of amygdala kindling-induced epileptogenesis: comparison of a GABA uptake inhibitor and diazepam. Epilepsy Res., 1, 63-69.
27. SOKOLOVA, S., ZHANG, C.L., ARENS, J., KHODOROV, B. & HEINEMANN, U. (1992). Effects of 5-(N-ethyl-N-isopropyl)-amiloride (EIPA) on different patterns of epileptiform activity in rat temporal cortex slices. Neurosci. Res. Commun., 10, 171-176.
28. VELLY, J., GRIMA, M., DECKER, N., CRAGOE, E.J. & SCHWARTZ, J. (1988). Effects of amiloride and its analogues on [3H]batrachotoxinin-A 20-alpha benzoate binding, [3H]tetracaine binding and 22Na influx. Eur. J. Pharmacol., 149, 97-105.
29. + exchangers. Physiol. Rev., 77, 51-74.
30. A receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density. J. Pharmacol. Exp. Ther., 289, 1626-1633.
31. WHITTINGHAM, T.S., WARMANN, E., ASSAF, H., SICK, T.J. & LA MANNA, J.C. (1989). Manipulating the intracellular environment of hippocampal slices: pH and high-energy phosphates. J. Neurosci. Meth., 28, 83-91.
32. XIONG, Z.Q., SAGGAU, P. & STRINGER, J.L. (2000). Activity dependent intracellular acidification correlates with the duration of seizure activity. J. Neurosci., 20, 1290-1296.