Pathogenicity of anti-DNA/glomerular autoantibodies - Weighing the evidence

Drug Discovery Today: Disease Models

Volumn 1, Issue 4, 2004, Pages 395-403

  Limaye, Nisha ^a   Mohan, Chandra ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIBODY; DNA ANTIBODY;

ANTIGEN ANTIBODY COMPLEX; DNA BINDING; GLOMERULONEPHRITIS; GLOMERULUS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FAILURE; KIDNEY PERFUSION; LUPUS ERYTHEMATOSUS NEPHRITIS; NEPHRITIS; NONHUMAN; PATHOGENICITY; PHENOTYPE; PROTEINURIA; REVIEW; SITE DIRECTED MUTAGENESIS; SYSTEMIC LUPUS ERYTHEMATOSUS; THEORY; UREMIA;

EID: 23744457014     PISSN: 17406757     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddmod.2004.11.008     Document Type: Review

References (63)

1. Vlahakos, D. et al. (1992) Murine monoclonal anti-DNA antibodies penetrate cells, bind to nuclei, and induce glomerular proliferation and proteinuria in vivo. J. Am. Soc. Nephrol. 2, 1345-1354
2. Yanase, K. et al. (1997) Receptor-mediated cellular entry of nuclear localizing anti-DNA antibodies via myosin 1. J. Clin. Invest. 100, 25-31
3. Lerner, R. A. et al. (1967) The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. J. Exp. Med. 989-1004
4. Dang, H. and Harbeck, R.J. (1984) The in vivo and in vitro glomerular deposition of isolated anti-double-stranded-DNA antibodies in NZB/W mice. Clin. Immunol. Immunopathol. 30, 265-278
5. Madaio, M.P. et al. (1987) Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits. J. Immunol. 138, 2883-2889
6. Mannik, M. et al. (1987) Immune complexes with cationic antibodies deposit in glomeruli more effectively than cationic antibodies alone. J. Immunol. 138, 4209-4217
7. Raz, E. et al. (1989) Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney. J. Immunol. 142, 3076-3082
8. Gauthier, V.J. and Mannik, M. (1990) A small proportion of cationic antibodies in immune complexes is sufficient to mediate their deposition in glomeruli. J. Immunol. 145, 3348-3352
9. Reininger, L. et al. (1990) Cryoglobulinemia induced by a murine IgG3 rheumatoid factor: skin vasculitis and glomerulonephritis arise from distinct pathogenic mechanisms. Proc. Natl. Acad. Sci. USA 87, 10038-10042
10. Assmann, K.J. et al. (1992) A nephritogenic rat monoclonal antibody to mouse aminopeptidase A. Induction of massive albuminuria after a single intravenous injection. J. Exp. Med. 175, 623-635
11. Kashihara, N. et al. (1992) Nephritogenicity of anti-proteoglycan antibodies in experimental murine lupus nephritis. Lab. Invest. 67, 752-760
12. Termaat, R.M. et al. (1992) Anti-DNA antibodies can bind to the glomerulus via two distinct mechanisms. Kidney Int. 42, 1363-1371
13. Vlahakos, D. V et al. (1992) Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites. Kidney Int. 41, 1690-1700
14. Katz, M.S. et al. (1993) Independently derived murine glomerular immune deposit-forming anti-DNA antibodies are encoded by near-identical VH gene sequences. J. Clin. Invest. 91, 402-408
15. Takahashi, S. et al. (1993) Cloning and cDNA sequence analysis of nephritogenic monoclonal antibodies derived from an MRL/lpr lupus mouse. Mol. Immunol. 30, 177-182
16. Katz, J.B. et al. (1994) Mutational analysis of an autoantibody: differential binding and pathogenicity. J. Exp. Med. 180, 925-932
17. Kramers, C. et al. (1994) Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo. J. Clin. Invest. 94, 568-577
18. Ohnishi, K. et al. (1994) Comparison of pathogenic and non-pathogenic murine antibodies to DNA: antigen binding and structural characteristics. Int. Immunol. 6, 817-830
19. Ehrenstein, M.R. et al. (1995) Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice. Kidney Int. 48, 705-711
20. Gilkeson, G.S. et al. (1995) The influence of variable-region somatic mutations on the specificity and pathogenicity of murine monoclonal anti-DNA antibodies. Clin. Immunol. Immunopathol. 76 (1 Pt. 1), 59-67
21. D'Andrea, D.M. et al. (1996) Lupus autoantibodies interact directly with distinct glomerular and vascular cell surface antigens. Kidney Int. 49, 1214-1221
22. van Bruggen, M.C. et al. (1996) Heparin and heparinoids prevent the binding of immune complexes containing nucleosomal antigens to the GBM and delay nephritis in MRL/lpr mice. Kidney Int. 50, 1555-1564
23. Foster, M.H. et al. (1997) Anti-laminin reactivity and glomerular immune deposition by in vitro recombinant antibodies. Autoimmunity 26, 231-243
24. van Bruggen, M.C. et al. (1997) Antigen specificity of anti-nuclear antibodies complexed to nucleosomes determines glomerular basement membrane binding in vivo. Eur. J. Immunol. 27, 1564-1569
25. Vargas, M.T. et al. (1997) Structural features of nephritogenic lupus autoantibodies. Methods 11, 62-69
26. Ravirajan, C.T. et al. (1998) Genetic, structural and functional properties of an IgG DNA-binding monoclonal antibody from a lupus patient with nephritis. Eur. J. Immunol. 28, 339-350
27. Chugh, S. et al. (2001) Aminopeptidase A: a nephritogenic target antigen of nephrotoxic serum. Kidney Int. 59, 601-613
28. Mostoslavsky, G. et al. (2001) Lupus anti-DNA autoantibodies cross-react with a glomerular structural protein: a case for tissue injury by molecular mimicry. Eur. J. Immunol. 31, 1221-1227
29. Meyers, K.E. et al. (2002) Human antiglomerular basement membrane autoantibody disease in XenoMouse II. Kidney Int. 61, 1666-1673
30. Trouw, L.A. et al. (2003) Glomerular deposition of C1q and anti-C1q antibodies in mice following injection of antimouse C1q antibodies. Clin. Exp. Immunol. 132, 32-39
31. Liang, Z. et al. (2004) Pathogenic Profiles and Molecular Signatures of Antinuclear Autoantibodies Rescued from NZM2410 Lupus Mice. J. Exp. Med. 199, 381-398
32. Sekine, H. et al. (2004) Enrichment of anti-glomerular antigen antibody-producing cells in the kidneys of MRL/MpJ-Fas(lpr) mice. J. Immunol. 172, 3913-3921
33. Hecht, B. et al. (1976) Prognostic indices in lupus nephritis. Medicine (Baltimore) 55, 163-181
34. Andrews, B.S. et al. (1978) Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J. Exp. Med. 148, 1198-1215
35. Hahn, B.H. (1998) Antibodies to DNA. N. Engl. J. Med. 338, 1359-1368
36. Cortes-Hernandez, J. et al. (2004) Antihistone and anti-double-stranded deoxyribonucleic acid antibodies are associated with renal disease in systemic lupus erythematosus. Am. J. Med. 116, 165-173
37. Xie, C. et al. (2003) Use of a novel elution regimen reveals the dominance of polyreactive antinuclear autoantibodies in lupus kidneys. Arthritis Rheum. 48, 2343-2352
38. Mannik, M. et al. (2003) Multiple autoantibodies form the glomerular immune deposits in patients with systemic lupus erythematosus. J. Rheumatol. 30, 1495-1504
39. Fries, J.F. et al. (1974) Estimating prognosis in systemic lupus erythematosus. Am. J. Med. 57, 561-565
40. Gladman, D.D. et al. (1979) Serologically active clinically quiescent systemic lupus erythematosus: a discordance between clinical and serologic features. Am. J. Med. 66, 210-215
41. Clough, J.D. et al. (1986) Antibodies against nuclear antigens: association with lupus nephritis. Cleve. Clin. Q. 53, 259-265
42. Tan, E.M. (1989) Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv. Immunol. 44, 93-151
43. Theofilopoulos, A.N. and Dixon, F.J. (1983) Murine models of systemic lupus erythematosus. pp. 269-390, Academic Press Inc
44. Yoshida, H. et al. (1981) Genetic studies of autoimmunity in New Zealand mice. III. Associations among anti-DNA antibodies, NTA, and renal disease in (NZB × NZW)F1 × NZW backcross mice. J. Immunol. 127, 433-437
45. Izui, S. et al. (1984) Induction of various autoantibodies by mutant gene lpr in several strains of mice. J. Immunol. 133, 227-233
46. Waters, S.T. et al. (2004) Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis. J. Exp. Med. 199, 255-264
47. Lefkowith, J.B. and Gilkeson, G.S. (1996) Nephritogenic autoantibodies in lupus: current concepts and continuing controversies. Arthritis Rheum. 39, 894-903
48. Shlomchik, M.J. and Madaio, M.P. (2003) The role of antibodies and B cells in the pathogenesis of lupus nephritis. Springer Semin. Immunopathol. 24, 363-375
49. Franek, F. and Dolnikova, J. (1991) Nucleosomes occurring in protein-free hybridoma cell culture. Evidence for programmed cell death. FEBS Lett. 284, 285-287
50. Bernstein, K.A. et al. (1995) Glomerular binding activity in MRL lpr serum consists of antibodies that bind to a DNA/histone/type IV collagen complex. J. Immunol. 154, 2424-2433
51. Di Valerio, R. et al. (1995) Murine lupus glomerulotropic monoclonal antibodies exhibit differing specificities but bind via a common mechanism. J. Immunol. 155, 2258-2268
52. Uwatoko, S. et al. (1991) Autoantibodies to the collagen-like region of C1Q deposit in glomeruli via C1Q in immune deposits. Clin. Immunol. Immunopathol. 61 (2 Pt. 1), 268-273
53. Uwatoko, S. et al. (1987) C1q solid-phase radioimmunoassay: evidence for detection of antibody directed against the collagen-like region of C1q in sera from patients with systemic lupus erythematosus. Clin. Exp. Immunol. 69, 98-106
54. Uwatoko, S. and Mannik, M. (1988) Low-molecular weight C1q-binding immunoglobulin G in patients with systemic lupus erythematosus consists of autoantibodies to the collagen-like region of C1q. J. Clin. Invest. 82, 816-824
55. Rordorf-Adam, C. et al. (1985) Serum amyloid P component and autoimmune parameters in the assessment of arthritis activity in MRL/lpr/lpr mice. Clin. Exp. Immunol. 61, 509-516
56. Uwatoko, S. et al. (1995) C1q-binding immunoglobulin G in MRL/1 mice consists of immune complexes containing antibodies to DNA. Clin. Immunol. Immunopathol. 75, 140-146
57. Deocharan, B. et al. (2002) Alpha-actinin is a cross-reactive renal target for pathogenic anti-DNA antibodies. J. Immunol. 168, 3072-3078
58. Mason, L.J. et al. (2004) Is alpha-actinin a target for pathogenic anti-DNA antibodies in lupus nephritis? Arthritis Rheum. 50, 866-870
59. Bhandari, S. et al. (1998) Association of anticardiolipin antibodies with intraglomerular thrombi and renal dysfunction in lupus nephritis. Q. J. Med. 91, 401-409
60. Loizou, S. et al. (2000) Significance of anticardiolipin and anti-beta(2)-glycoprotein I antibodies in lupus nephritis. Rheumatology (Oxford) 39, 962-968
61. Foster, M.H. et al. (1993) Molecular analysis of spontaneous nephrotropic anti-laminin antibodies in an autoimmune MRL-lpr/lpr mouse. J. Immunol. 151, 814-824
62. Ben-Yehuda, A. et al. (1995) The urine of SLE patients contains antibodies that bind to the laminin component of the extracellular matrix. J. Autoimmun. 8, 279-291
63. Atta, M.S. et al. (1994) Human anti-fibronectin antibodies in systemic lupus erythematosus: occurrence and antigenic specificity. Clin. Exp. Immunol. 96, 20-25