In vitro antiviral activity of three enantiomeric sesquiterpene lactones from Senecio species against hepatitis B virus

Antiviral Chemistry and Chemotherapy

Volumn 16, Issue 4, 2005, Pages 277-282

  Li, Haibo ^a   Zhou, Changxin ^a   Zhou, Linfu ^b   Chen, Zhi ^b   Yang, Leixiang ^a   Bai, Hua ^c   Wu, Xiumei ^c   Peng, Hua ^d   Zhao, Yu ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c Zhejiang Hisun Naturelite Pharmaceutical R and D Co Ltd   (China)

^d KUNMING INSTITUTE OF BOTANY   (China)

Author keywords

Antiviral activity; Enantiomeric sesquiterpene lactones; Hepatitis B virus; Senecio species

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; PLANT EXTRACT; SESQUITERPENE LACTONE DERIVATIVE; VIRUS DNA;

ANTIGEN EXPRESSION; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; ENANTIOMER; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SENECIO; VIRION;

EID: 23744445349     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632020501600407     Document Type: Article

References (28)

1. Abe A, Inoue K, Tanaka T, Kato J, Kajiyama N, Kawaguchi R, Tanaka S, Yoshiba M & Kohara M (1999) Quantitation of hepatitis B virus genomic DNA by real-time detection PCR. Journal of Clinical Microbiology 37:2899-2903.
2. Beasley RP (1988) Hepatitis B virus. The major etiology of hepatocellular carcinoma. Cancer 61:1942-1956.
3. Brechtbuehl K, Whalley SA, Dusheiko GM & Saunders NA (2001) A rapid real-time quantitative polymerase chain reaction for hepatitis B virus. Journal of Virological Methods 93:105-113.
4. Chen HC, Chou CK, Lee SD, Wang JC & Yeh SF (1995) Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells. Antiviral Research 27:99-109.
5. Chiang LC, Ng LT, Liu LT, Shieh D & Lin CC (2003) Cytotoxicity and anti-hepatitis B virus activities of saikosaponins from Bupleurum species. Planta Medica 69:705-709
6. Dai JR, Chai H, Pezzuto JM & Kinghorn DA (1993) Cytotoxicity constituents of the roots of the Indonesian medicinal plant Fibraurea chloroleuca. Phytotherapy Research 7:290-294.
7. Di Bisceglie AM, Rustgi VK, Hoofanagle JH, Dusheiko GM & Lotze MT (1988) Hepatocellular carcinoma. Annals of Internal Medicine. 108:390-401.
8. Fu L, Liu SH & Cheng YC (1999) Sensitivity of L-(-)2′,3′- dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues. Biochemical Pharmacology 57:1351-1359.
9. Grue MR & Liddell JR (1993) Pyrrolizidine alkaloids from Senecio chrysocoma. Phytochemistry 33:1517-1519.
10. Hehner SP, Heinrich M, Bork PM, Vogt M, Ratter F, Lehmann V, Schulze-Osthoff K, Droge W & Schmitz ML (1998) Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of Ikappa B-alpha and Ikappa B-beta. Journal of Biological Chemistry 273:1288-1297.
11. Huang RL, Chen CC, Huang HL, Chang CG, Chen CF, Chang CM & Hsieh MT (2000) Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. Planta Medica 66:694-698.
12. Huang BY, Lee JH, Kim TH, Hong YS, Ro JS, Lee KS & Lee JJ (2002) Furanoligularenone, an eremophilane from Ligularia fischeri, inhibits the LPS-induced production of nitric oxide and prostaglandin E2 in macrophage RAW264.7 cells. Planta Medica 68:101-105.
13. Hwang D, Fischer NH, Jang BC, Tak H & Kim DG (1996) Inhibition of the expression of inducible cyclooxygenase and proinfiammatory cytokines by sesquiterpene lactones in macrophage correlates with the inhibition of MAP kinases. Biochemical & Biophysical Research Communications 226:810-818.
14. Kim TG, Kang SY, Jung KK, Knag JH, Lee E, Han MH & Kim SH (2001) Antiviral activities of extracts isolated from Terminalis chebula Retz., Sanguisorba officinalis L., Rubus coreanus Miq. and Rheum palmatum L. against hepatitis B virus. Phytotherapy Research 15:718-720.
15. Lee WM (1997) Hepatitis B virus infection. New England Journal of Medicine 337:1733-1745.
16. Li YM, Mu XQ, Feng JT & Zhang X (2002) [Primary study on the fungicidal activity of Compositae plants]. Journal of Northwest SciTech University of Agriculture and Forest 30:68-72. Chinese.
17. Ling R, Mutimer D, Ahmed M, Boxall EH, Ellas E, Dusheiko GM & Harrison TJ (1996) Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine. Hepatology 24:711-713.
18. Niederau C, Heintges T, Lange S, Goldmann G, Niedrau CM, Mohr L & Häussinger (1996) Long-term follow-up of HBeAg-postive patients treated with interferon alfa for chronic hepatitis B. New England Journal of Medicine 334:1422-1427.
19. Pai CB, Liu SH, Zhu YL, Chu CK & Cheng YC (1996) Inhibition of hepatitis B virus by a novel L-nucleoside, 2′-fluoro-5-methyl-β-L- arabinofuranosyl uracil. Antimicrobial Agents & Chemotherapy 40:380-386.
20. Park HJ, Kwon SH, Han YN, Choi JW, Miyanoto K, Lee SH & Lee KT (2001) Apoptosis-inducing costunolide and a novel acyclic monoterpene from the stem bark of Magnolia sieboldii. Archives of Pharmacal Research 24:342-348.
21. Robles M, Aregullin M, West J & Rodriguez E (1995) Recent studies on the zoopharmacognosy, pharmacology, and neurotoxicology of sesquiterpene lactone. Planta Medica 61:199-203.
22. Sells MA, Chen ML & Acs G (1987) Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA. Proceedings of the National Academy of Sciences, USA 84:1005-1009.
23. Tipples GA, Ma MM, Fischer KP, Bain VG, Kneteman NM & Tyrrell DL (1996) Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo. Hepatology 24:714-717.
24. Tommasi ND, Rastrelli L, Lauro MR & Aquino R (1998) Polyhydroxylated triterpenes from Senecio pseudotites. Phytochemistry 49:1123-1125.
25. Yeh SF, Gupta M, Sarma DNK & Mitra SK (2003) Downregulation of hepatitis B surface antigen expression in human hepatocellular carcinoma cell lines by HD-30, a polyherbal formulation. Phytotherapy Research 17:89-91.
26. Ying CX, Clercq ED & Neyts J (2003) Selective inhibition of hepatitis B virus replication by RNA interference. Biochemical & Biophysical Research Communications 309:482-484.
27. Zhao Y, Wang P, Parsons S, Rankin DWH, Guéritte F, Sevenét T, Yu H, He YN & Hao XJ (2002) Saluenolide A, a novel eremophilanolide from Senecio saluenensis. Chinese Chemical Letters 13:333-334.
28. Zhao Y, Wang P, Hao XJ, Parsons S, Rankin DW H, Shi H, Yu H, Sevenét T & Guéritte F (2002) Enantiomeric sesquiterpene lactones from Senecio tsoongianus. Chinese Chemical Letters 13:754-757.