RNA transfer by electroporation into mature dendritic cells leading to reactivation of effector-memory cytotoxic T lymphocytes: A quantitative analysis

Molecular Therapy

Volumn 12, Issue 4, 2005, Pages 734-743

  Javorovic, Miran ^a   Pohla, Heike ^a,b   Frankenberger, Bernhard ^a   Wölfel, Thomas ^c   Schendel, Dolores J ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

CDK4; Dendritic cells; Effector memory cytotoxic T lymphocytes; EGFP; Electroporation; Melanoma; Peptide MHC ligands; RNA transfection; Tumor immunotherapy; Tyrosinase

Indexed keywords

CYCLIN DEPENDENT KINASE 4; DENDRITIC CELL VACCINE; MELANOMA ANTIGEN; MONOPHENOL MONOOXYGENASE;

ARTICLE; CANCER IMMUNOTHERAPY; CELL MATURATION; CONTROLLED STUDY; CORRELATION FUNCTION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; ELECTROPORATION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOGENICITY; MELANOMA; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RNA TRANSPORT; T LYMPHOCYTE ACTIVATION; VACCINE PRODUCTION;

CELL LINE, TUMOR; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; ELECTROPORATION; HUMANS; IMMUNOTHERAPY; LYMPHOCYTE ACTIVATION; MELANOMA; PHENOTYPE; RNA; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION;

EID: 23744438434     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2005.03.034     Document Type: Article

References (33)

1. W.H. Clark Jr. et al. Model predicting survival in stage I melanoma based on tumor progression J. Natl. Cancer. Inst. 8 1989 1893-1904
2. C.G. Clemente M.C. Mihm Jr. R. Bufalino S. Zurrida P. Collini and N. Cascinelli Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma Cancer 77 1996 1303-1310
3. M.E. Dudley et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes Science 298 2002 850-854
4. T. Ramirez-Montagut M.J. Turk J.D. Wolchok J.A. Guevara-Patino and A.N. Houghton Immunity to melanoma: Unraveling the relation of tumor immunity and autoimmunity Oncogene 22 2003 3180-3187
5. T. Wolfel et al. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma Science 269 1995 1281-1284
6. V. Cerundolo I.F. Hermans and M. Salio Dendritic cells: A journey from laboratory to clinic Nat. Immunol. 5 2004 7-10
7. G. Schuler B. Schuler-Thurner and R.M. Steinman The use of dendritic cells in cancer immunotherapy Curr. Opin. Immunol. 15 2003 138-147
8. R.M. Steinman and M.C. Nussenzweig Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance Proc. Natl. Acad. Sci. USA 99 2002 351-358
9. M.B. Lutz and G. Schuler Immature, semi-mature and fully mature dendritic cells: Which signals induce tolerance or immunity? Trends Immunol. 23 2002 445-449
10. E. Jager D. Jager and A. Knuth Clinical cancer vaccine trials Curr. Opin. Immunol. 14 2002 178-182
11. D. Boczkowski S.K. Nair D. Snyder and E. Gilboa Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo J. Exp. Med. 184 1996 465-472
12. A. Heiser et al. Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors J. Clin. Invest. 109 2002 409-417
13. Z. Su et al. Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells Cancer Res. 63 2003 2127-2133
14. A. Bonehill et al. Messenger RNA-electroporated dendritic cells presenting MAGE-A3 simultaneously in HLA class I and class II molecules J. Immunol. 172 2004 6649-6657
15. E. Eppler H. Horig H.L. Kaufman P. Groscurth and L. Filgueira Carcinoembryonic antigen (CEA) presentation and specific T cell-priming by human dendritic cells transfected with CEA-mRNA Eur. J. Cancer 38 2002 184-193
16. X. Liao et al. Transfection of RNA encoding tumor antigens following maturation of dendritic cells leads to prolonged presentation of antigen and the generation of high-affinity tumor-reactive cytotoxic T lymphocytes Mol. Ther. 9 2004 757-764
17. E.J. Wherry K.A. Puorro A. Porgador and L.C. Eisenlohr The induction of virus-specific CTL as a function of increasing epitope expression: responses rise steadily until excessively high levels of epitope are attained J. Immunol. 163 1999 3735-3745
18. R.Y. Tsien The green fluorescent protein Annu. Rev. Biochem. 67 1998 509-544
19. X. Li et al. Generation of destabilized green fluorescent protein as a transcription reporter J. Biol. Chem. 273 1998 34970-34975
20. S. Morel et al. Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells Immunity 12 2000 107-117
21. V.E. Velculescu et al. Analysis of human transcriptomes Nat. Genet. 23 1999 387-388
22. M. Johansson A. Takasaki L. Lenner K. Arstrand and B. Kagedal Quantitative relationships between pigment-related mRNA and biochemical melanoma markers in melanoma cell lines Melanoma Res. 12 2002 193-200
23. D.M. Ashley B. Faiola S. Nair L.P. Hale D.D. Bigner and E. Gilboa Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors J. Exp. Med. 186 1997 1177-1182
24. D. Boczkowski S.K. Nair J.H. Nam H.K. Lyerly and E. Gilboa Induction of tumor immunity and cytotoxic T lymphocyte responses using dendritic cells transfected with messenger RNA amplified from tumor cells Cancer Res. 60 2000 1028-1034
25. D. Mumberg M. Wick and H. Schreiber Unique tumor antigens redefined as mutant tumor-specific antigens Semin. Immunol. 8 1996 289-293
26. L. Rivoltini et al. Quantitative correlation between HLA class I allele expression and recognition of melanoma cells by antigen-specific cytotoxic T lymphocytes Cancer Res. 55 1995 3149-3157
27. A.I. Riker et al. Threshold levels of gene expression of the melanoma antigen gp100 correlate with tumor cell recognition by cytotoxic T lymphocytes Int. J. Cancer. 86 2000 818-826
28. R.D. Salter D.N. Howell and P. Cresswell Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids Immunogenetics 21 1985 235-246
29. M.J. Visseren et al. CTL specific for the tyrosinase autoantigen can be induced from healthy donor blood to lyse melanoma cells J. Immunol. 154 1995 3991-3998
30. E. Noessner et al. Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells J. Immunol. 169 2002 5424-5432
31. C. Wolfel et al. Transporter (TAP)- and proteasome-independent presentation of a melanoma-associated tyrosinase epitope Int. J. Cancer 88 2000 432-438
32. S.K. Nair D. Boczkowski M. Morse R.I. Cumming H.K. Lyerly and E. Gilboa Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA Nat. Biotechnol. 16 1998 364-369
33. A. Heiser et al. Induction of polyclonal prostate cancer-specific CTL using dendritic cells transfected with amplified tumor RNA J. Immunol. 166 2001 2953-2960