Overexpression of drebrin A in immature neurons induces the accumulation of F-actin and PSD-95 into dendritic filopodia, and the formation of large abnormal protrusions

Molecular and Cellular Neuroscience

Volumn 30, Issue 1, 2005, Pages 149-157

  Mizui, Toshiyuki ^a   Takahashi, Hideto ^a   Sekino, Yuko ^a,b,c   Shirao, Tomoaki ^a  

^a GUNMA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DREBRIN; DREBRIN A; F ACTIN; GREEN FLUORESCENT PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; POSTSYNAPTIC DENSITY PROTEIN 95; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL MATURATION; CELL STRUCTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DENDRITIC CELL; DENDRITIC SPINE; FEMALE; FETUS; FILOPODIUM; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MEGAPODIUM; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVE ENDING; NERVE MALFORMATION; NEUROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT;

ACTINS; ANIMALS; CELLS, CULTURED; DENDRITES; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; MICROTUBULE-ASSOCIATED PROTEINS; NERVE TISSUE PROTEINS; NEURONS; NEUROPEPTIDES; PREGNANCY; PRESYNAPTIC TERMINALS; PSEUDOPODIA; RATS; RATS, WISTAR; SPINAL CORD;

EID: 23644462713     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcn.2005.06.008     Document Type: Article

References (28)

1. K. Abe, O. Chisaka, F. Van Roy, and M. Takeichi Stability of dendritic spines and synaptic contacts is controlled by alpha N-catenin Nat. Neurosci. 7 2004 357 363
2. H. Asada, K. Uyemura, and T. Shirao Actin-binding protein, drebrin, accumulates in submembranous regions in parallel with neuronal differentiation J. Neurosci. Res. 38 1994 149 159
3. M.E. Dailey, and S.J. Smith The dynamics of dendritic structure in developing hippocampal slices J. Neurosci. 16 1996 2983 2994
4. A. Dunaevsky, A. Tashiro, A. Majewska, C. Mason, and R. Yuste Developmental regulation of spine motility in the mammalian central nervous system Proc. Natl. Acad. Sci. U. S. A. 96 1999 13438 13443
5. A.E. El-Husseini, E. Schnell, D.M. Chetkovich, R.A. Nicoll, and D.S. Bredt PSD-95 involvement in maturation of excitatory synapses Science 290 2000 1364 1368
6. M. Fischer, S. Kaech, D. Knutti, and A. Matus Rapid actin-based plasticity in dendritic spines Neuron 20 1998 847 854
7. K.M. Harris Structure, development, and plasticity of dendritic spines Curr. Opin. Neurobiol. 9 1999 343 348
8. K.M. Harris, and S.B. Kater Dendritic spines: cellular specializations imparting both stability and flexibility to synaptic function Annu. Rev. Neurosci. 17 1994 341 371
9. K. Hayashi, and T. Shirao Change in the shape of dendritic spines caused by overexpression of drebrin in cultured cortical neurons J. Neurosci. 19 1999 3918 3925
10. K. Hayashi, R. Ishikawa, L.H. Ye, X.L. He, K. Takata, K. Kohama, and T. Shirao Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex J. Neurosci. 16 1996 7161 7170
11. K. Hayashi, K. Suzuki, and T. Shirao Rapid conversion of drebrin isoforms during synapse formation in primary culture of cortical neurons Dev. Brain Res. 111 1998 137 141
12. R. Ishikawa, K. Hayashi, T. Shirao, Y. Xue, T. Takagi, Y. Sasaki, and K. Kohama Drebrin, a development-associated brain protein from rat embryo, causes the dissociation of tropomyosin from actin filaments J. Biol. Chem. 269 1994 29928 29933
13. N. Kojima, T. Shirao, and K. Obata Molecular cloning of a developmentally regulated brain protein, chicken drebrin A and its expression by alternative splicing of the drebrin gene Mol. Brain Res. 19 1993 101 114
14. X.M. Ma, J. Huang, Y. Wang, B.A. Eipper, and R.E. Mains Kalirin, a multifunctional Rho guanine nucleotide exchange factor, is necessary for maintenance of hippocampal pyramidal neuron dendrites and dendritic spines J. Neurosci. 23 2003 10593 10603
15. D.T. Pak, S. Yang, S. Rudolph-Correia, E. Kim, and M. Sheng Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP Neuron 31 2001 289 303
16. J.J. Renger, C. Egles, and G. Liu A developmental switch in neurotransmitter flux enhances synaptic efficacy by affecting AMPA receptor activation Neuron 29 2001 469 484
17. C. Sala, V. Piech, N.R. Wilson, M. Passafaro, G. Liu, and M. Sheng Regulation of dendritic spine morphology and synaptic function by Shank and Homer Neuron 31 2001 115 130
18. T. Shirao The roles of microfilament-associated proteins, drebrins, in brain morphogenesis: a review J. Biochem. (Tokyo) 117 1995 231 236
19. T. Shirao, and K. Obata Two acidic proteins associated with brain development in chick embryo J. Neurochem. 44 1985 1210 1216
20. T. Shirao, and K. Obata Immunochemical homology of 3 developmentally regulated brain proteins and their developmental change in neuronal distribution Brain Res. 394 1986 233 244
21. T. Shirao, and Y. Sekino Clustering and anchoring mechanisms of molecular constituents of postsynaptic scaffolds in dendritic spines Neurosci. Res. 40 2001 1 7
22. T. Shirao, H.K. Inoue, Y. Kano, and K. Obata Localization of a developmentally regulated neuron-specific protein S54 in dendrites as revealed by immunoelectron microscopy Brain Res. 413 1987 374 378
23. T. Shirao, N. Kojima, K. Nabeta, and K. Obata Two isoforms of drebrins, developmentally regulated brain protein, in rat Proc. Jpn. Acad. 65 1989 169 172
24. T. Shirao, K. Hayashi, R. Ishikawa, K. Isa, H. Asada, K. Ikeda, and K. Uyemura Formation of thick, curving bundles of actin by drebrin A expressed in fibroblasts Exp. Cell Res. 215 1994 145 153
25. D.A. Sholl Dendritic organization in the neurons of the visual and motor cortices of the cat J. Anat. 87 1953 387 406
26. H. Takahashi, Y. Sekino, S. Tanaka, T. Mizui, S. Kishi, and T. Shirao Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis J. Neurosci. 23 2003 6586 6595
27. R. Yuste, and T. Bonhoeffer Morphological changes in dendritic spines associated with long-term synaptic plasticity Annu. Rev. Neurosci. 24 2001 1071 1089
28. N.E. Ziv, and S.J. Smith Evidence for a role of dendritic filopodia in synaptogenesis and spine formation Neuron 17 1996 91 102