Clinical use of relaxin to facilitate birth reasons for investigating the premise

Annals of the New York Academy of Sciences

Volumn 1041, Issue , 2005, Pages 351-366

  Lee, Hyung Yul ^a   Zhao, Shuangping ^a   Fields, P A ^b   Sherwood, O D ^a,c  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Birth; Cervical growth; Cervical softening; Relaxin

Indexed keywords

ESTROGEN; MIFEPRISTONE; MISOPROSTOL; PROGESTERONE; PROSTAGLANDIN E2; RELAXIN;

ANIMAL MODEL; CESAREAN SECTION; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; HEALTH CARE COST; LABOR INDUCTION; LABOR PAIN; MEDICAL ETHICS; NONHUMAN; RAT; SWINE; UNITED STATES; UTERINE CERVIX DILATATION; VAGINAL DELIVERY;

ANIMALIA;

EID: 23644457490     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1282.056     Document Type: Conference Paper

References (53)

1. MARTIN, J.A., B.E. HAMILTON, P.D. SUTTON, et al. 2003. Births: final data for 2002. Natl. Vital Stat. Rep. 52: 1-116.
2. RAYBURN, W.F. 2002. Preinduction cervical ripening: basis and methods of current practice. Obstet. Gynecol. Surv. 57: 683-692.
3. POMA, P.A. 1999. Cervical ripening: a review and recommendations for clinical practice. J. Reprod. Med. 44: 657-668.
4. XENAKIS, E.M., J.M. PIPER, D.L. CONWAY, et al. 1997. Induction of labor in the nineties: conquering the unfavorable cervix. Obstet. Gynecol. 90: 235-239.
5. LILFORD, R.J., H.A. VAN COEVERDEN DE GROOT, P.J. MOORE, et al. 1990. The relative risks of cesarean section (intrapartum and elective) and vaginal delivery: a detailed analysis to exclude the effects of medical disorders and other acute pre-existing physiological disturbances. Br. J. Obstet. Gynaecol. 97: 883-892.
6. MINKOFF, H. & F.A. CHERVENAK. 2003. Elective primary cesarean delivery. N. Engl. J. Med. 348: 946-950.
7. SHARMA, G., F.A. CHERVENAK, L.B. MCCULLOUGH, et ai. 2004. Ethical considerations in elective cesarean delivery. Clin. Obstet. Gynecol. 47: 404-408.
8. ACOG COMMITTEE ON PRACTICE BULLETINS-OBSTETRICS. 2000. ACOG Practice Bulletin: Induction of Labor. Int. J. Gynaecol. Obstet. 69: 283-292.
9. HOFMEYR, G.J. & A.M. GULMEZOGLU. 2003. Vaginal misoprostol for cervical ripening and induction of labor. Cochrane Database Syst. Rev. 2: CD000941.
10. KELLY, A.J., J. KAVANAGH & J. THOMAS. 2002. Vaginal prostaglandin (PGE2 and PGF2α) for induction of labour at term. Cochrane Database Syst. Rev. 2: CD003101.
11. GOLDBERG, A.B. & D.A. WING. 2003. Induction of Labor: the misoprostol controversy. J. Midwifery and Womens Health 48: 244-248.
12. ROZENBERG, P., S. CHEVRET, M.-V. SENAT, et al. 2004. A randomized trial that compared intravaginal misoprostol and dinoprostone vaginal insert in pregnancies at high risk of fetal distress. Am. J. Obstet. Gynecol. 191: 247-253.
13. ELHASSAN, M., O.A. MIRGHANI & I. ADAM. 2004. Intravaginal misoprostol vs. dinoprostone as cervical ripening and labor-inducing agents. Int. J. Gynaecol. Obstet. 85: 285-286.
14. CARRY, D., G.D. FIGUEROA, R.B. KALISH, et al. 2003. Randomized controlled trial of vaginal misoprostol versus dinoprostone vaginal insert for labor induction. J. Matern. Fetal Neonatal Med. 13: 254-259.
15. PANDIS, G.K., A.T. PAPAGEORGHIOU, C.M. OTIGBAH, et al. 2001. Randomized study of vaginal misoprostol (PGEI) and dinoprostone gel (PGE2) for induction of labor at term. Ultrasound Obstet. Gynecol. 18: 629-635.
16. ELDRIDGE-WHITE, R., R.A. EASTER, D.M. HEATON, et al. 1989. Hormonal control of the cervix in pregnant gilts. I. Changes in the physical properties of the cervix correlate temporally with elevated serum levels of estrogen and relaxin. Endocrinology 125: 2996-3003.
17. SHERWOOD, O.D., V.E. CRNEKOVIC, W.L. GORDON, et al. 1980. Radioimmunoassay of relaxin throughout pregnancy and during parturition in the rat. Endocrinology 107: 691-698.
18. O'DAY, M.B., R.J. WINN, R.A. EASTER, et al. 1989. Hormonal control of the cervix in pregnant gilts. II. Relaxin promotes changes in the physical properties of the cervix in ovariectomized hormone-treated pregnant gilts. Endocrinology 125: 3004-3010.
19. DOWNING, S.J. & O.D. SHERWOOD. 1985. The physiological role of relaxin in the pregnant rat. III. The influence of relaxin on cervical extensibility. Endocrinology 116: 1215-1220.
20. HWANG, J.J. & O.D. SHERWOOD. 1988. Monoclonal antibodies specific for rat relaxin. III. Passive immunization with monoclonal antibodies throughout the second half of pregnancy reduces cervical growth and extensibility in intact rats. Endocrinology 123: 2486-2490.
21. NARA, B.S., F.A. WELK, J.E. RUTHERFORD, et al. 1982. Effect of relaxin on parturition and frequency of live births in pigs. J. Reprod. Fertil. 66: 359-365.
22. DOWNING, S.J. & O.D. SHERWOOD. 1985. The physiological role of relaxin in the pregnant rat. I. The influence of relaxin on parturition. Endocrinology 116: 1200-1205.
23. LAO GUICO-LAMM, M. & O.D. SHERWOOD. 1988. Monoclonal antibodies specific for rat relaxin. II. Passive immunization with monoclonal antibodies throughout the second half of pregnancy disrupts birth in intact rats. Endocrinology 123: 2479-2485.
24. BURGER, L.L. & O.D. SHERWOOD. 1995. Evidence that cellular proliferation contributes to relaxin-induced growth of both the vagina and the cervix in the pregnant rat. Endocrinology 136: 4820-4826.
25. EDDIE, L.W., R.J. BELL, A. LESTER, et al. 1986. Radioimmunoassay of relaxin in pregnancy with an analogue of human relaxin. Lancet 1(8494): 1344-1346.
26. SHERWOOD, O.D. & E.M. O'BYRNE. 1974. Purification and characterization of porcine relaxin. Arch. Biochem. Biophys. 160: 185-196.
27. SHERWOOD, O.D., E.S. JUNGHEIM, J.L. MASFERRER. et al. 1998. Evidence that relaxin's effects on growth and softening of the cervix are not mediated through prostaglandins in the rat. Endocrinology 139: 867-873.
28. SHERWOOD, O.D., L.M. OLSON, S. ZHAO, et at. 2000. Inhibition of nitric oxide synthase activity diminishes the acute effects of relaxin on growth, but not softening, of the cervix in the rat. Endocrinology 141: 2458-2464.
29. HALL, J.A., T.C. CANTLEY, B.N. DAY, el at. 1990. Uterotropic actions of relaxin in prepubertal gilts. Biol. Reprod. 42: 769-774.
30. HALL, J.A. & R.V. ANTHONY. 1993. Influence of ovarian steroids on relaxin-induced distensibility and compositional changes in the porcine cervix. Biol. Reprod. 48: 1348-1353.
31. WANG-LEE, J.L., L.A. LENHAKT. K.M. OHLETH, el at. 1998. Regulation of urokinase-and tissue-type plasminogen activator by relaxin in the uterus and cervix of the prepubertal gilt. J. Reprod. Fertil. 114: 119-125.
32. MIN, G., M.G. HARTZOG, R.L. JENNINGS, et al. 1997. Evidence that endogenous relaxin promotes growth of the vagina and uterus during pregnancy in gilts. Endocrinology 138: 560-565.
33. LELAIDIER, C., C. BATON, J.L. BENIFLA, et al. 1994. Mifepristone for labour induction after previous cesarean section. Br. J. Obstet. Gynaecol. 101: 501-503.
34. GIACOLONE RL., V. TARGOSZ, F. LAFFARGUE, et al. 1998. Cervical ripening with mifepritone before labor induction: a randomized study. Obstet. Gynecol. 92: 487-492.
35. STENLUND, P.M., G. EKMAN. A.R. AEDO, et al. 1999. Induction of labor with mifepristone-a randomized, double-blind study versus placebo. Acta Obstet. Gynecol. Scand. 78: 793-798.
36. ELLIOTT, C.L., J.E. BRENNAND & A.A. CALDER. 1998. The effects of mifepristone on cervical ripening and labor induction in primigravidae. Obtet. Gynecol. 92: 804-809.
37. WING, D.A., M.J. FASSETT & D.R. MISHELL. 2000. Mifepristone for preinduction cervical ripening beyond 41 weeks gestation: a randomized controlled trial. Obstet. Gynecol. 96: 543-548.
38. CHWALISZ, K. 1994. The use of progesterone antagonists for cervical ripening and as an adjunct to labour and delivery. Hum. Reprod. 9: 131-161.
39. ZHAO, S. & O.D. SHERWOOD. 2004. Induction of labor with RU 486 (mifepristone) in relaxin-deficient rats: antepartum administration of relaxin facilitates delivery and increases pup survival. Am. J. Obstet. Gynecol. 190: 229-238.
40. SHERWOOD, O.D. 2004. Relaxin's physiological roles and other diverse actions. Endocr. Rev. 25: 205-234.
41. SHERWOOD, O.D., S.J. DOWNING, T.G. GOLDS, et at. 1983. Influence of light-dark cycle on antepartum serum relaxin and progesterone immunoactivity levels and on birth in the rat. Endocrinology 113: 997-1003.
42. LAO GUICO-LAMM, M., E.W. Voss & O.D. SHERWOOD. 1988. Monoclonal antibodies for rat relaxin. I. Production and characterization of monoclonal antibodies that neutralize rat relaxin's bioactivity in vivo. Endocrinology 123: 2472-2478.
43. BURGER, L.L. & O.D. SHERWOOD. 1998. Relaxin increases the accumulation of new epithelial and stromal cells in the rat cervix during the second half of pregnancy. Endocrinology 139: 3984-3995.
44. LEE, H.-Y., S. ZHAO, P.A. FIELDS, el al. 2005. The extent to which relaxin promotes proliferation and inhibits apoptosis of cervical epithelial cells is greatest during late pregnancy in rats. Endocrinology 146: 511-518.
45. ZHAO, S., P.A. FIELDS & O.D. SHERWOOD. 2001. Evidence that relaxin inhibits apoptosis in the cervix and the vagina during the second half of pregnancy in the rat. Endocrinology 142: 2221-2229.
46. SHERWOOD, O.D. 1994. Relaxin. In Physiology of Reproduction, 2nd Ed., Vol. I. E. Knobil & J.D. Neill, Eds. :861-1009. Raven Press. Ltd. New York, NY.
47. DOWNING, S.J. & O.D. SHERWOOD. 1985. The physiological role of relaxin in the pregnant rat. 11. The influence of relaxin on uterine contractile activity. Endocrinology 116: 1206-1214.
48. PORTER, D.G. 1979. The myometrium and the relaxin enigma. Anim. Reprod. Sci. 2: 77-96.
49. ERICKSON, M.S. & E.N. UNEMORI. 2001. Relaxin clinical trials in systemic sclerosis. In Relaxin 2000. G.W. Tregear, R. Ivell, R.A. Bathgate & J.D. Wade, Eds. :373-381. Kluwer Academic Publishers. Dordrecht, The Netherlands.
50. SIEBOLD, J.R., J.H. KORN, R. SIMMS, et al. 2000. Recombinant human relaxin in the treatment of scleroderma. Ann. Intern. Med. 132: 871-879.
51. PALEJWALA, S., D.E. STEIN, G. WEISS, et al. 2001. Relaxin positively regulates matrix metalloproteinase expression in human lower uterine segment fibroblasts using a tyrosine kinase signaling pathway. Endocrinology 142: 3405-3413.
52. BELL, R.J., M. PERMEZEL, A. MACLENNAN, et al. 1997. A randomized, double blind, placebo controlled trial of the safety of vaginal recombinant human relaxin for cervical ripening. Obstet. Gynecol. 82: 328-333.
53. BRENNAND, J.E., A.A. CALDER, C.R. LEITCH, et al. 1997. Recombinant human relaxin as a cervical ripening agent. Br. J. Obstet. Gynaecol. 104: 775-780.