Novel synthesis of nucleoside 5′-phosphoramidates through reaction of nucleoside triphosphates with amines mediated by trimethylsilyl chloride

Journal of Organic Chemistry

Volumn 70, Issue 17, 2005, Pages 6676-6679

  Zhu, Jigang ^a   Han, Bo ^a   Fu, Hua ^a   Jiang, Yuyang ^a   Zhao, Yufen ^a  

^a TSINGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYSIS; ENZYMES; ESTERS; REACTION KINETICS; RNA; SYNTHESIS (CHEMICAL);

AMINO ACID METHYL ESTERS; BIOLOGICAL SYSTEM; ENZYMATIC REACTIONS; NUCLEOSIDE TRIPHOSPHATES (NTP);

NITROGEN COMPOUNDS;

AMINO ACID METHYL ESTER DERIVATIVE; CHLOROTRIMETHYLSILANE; DNA; HYDROLASE; NUCLEASE; NUCLEOSIDE 5' PHOSPHORAMIDATE DERIVATIVE; NUCLEOSIDE DERIVATIVE; NUCLEOSIDE PHOSPHATE; NUCLEOSIDE TRIPHOSPHATE; RNA; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION KINETICS; COVALENT BOND; ENZYME MECHANISM; LIGATION; PRODUCT RECOVERY; REACTION ANALYSIS; REACTION OPTIMIZATION; SYNTHESIS;

AMINES; NUCLEOTIDES; ORGANOPHOSPHORUS COMPOUNDS; PYRIDINES; TRIMETHYLSILYL COMPOUNDS;

EID: 23644457163     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo050716i     Document Type: Article

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