메뉴 건너뛰기




Volumn 23, Issue 4, 2002, Pages 227-236

A controlled randomised trial of t-UDCA as adjuvant to interferon for treatment of chronic hepatitis C: An interferon sparing effect of t-UDCA

Author keywords

Hepatitis C virus; Therapy of chronic hepatitis

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; HUMOFERON; TAUROURSODEOXYCHOLIC ACID; TUDCABIL;

EID: 23644431868     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6346(02)00007-4     Document Type: Article
Times cited : (5)

References (48)
  • 1
    • 0034069745 scopus 로고    scopus 로고
    • Natural history of hepatitis C: Its impact on clinical management
    • di Bisceglie AM. Natural history of hepatitis C: its impact on clinical management. Hepatology 2000;31:1014-8.
    • (2000) Hepatology , vol.31 , pp. 1014-1018
    • Di Bisceglie, A.M.1
  • 2
    • 1842291578 scopus 로고    scopus 로고
    • The treatment of chronic viral hepatitis
    • Hoofnagle JH, di Bisceglie AM. The treatment of chronic viral hepatitis. N Engl J Med 1997;336:347-56.
    • (1997) N Engl J Med , vol.336 , pp. 347-356
    • Hoofnagle, J.H.1    Di Bisceglie, A.M.2
  • 3
    • 0027999941 scopus 로고
    • Prevalence of chronic liver disease in the general population of northern Italy: The Dionysos Study
    • Bellentani S, Tiribelli C, Saccoccio G, Sodde M, Fratti N, De Martin C, et al. Prevalence of chronic liver disease in the general population of northern Italy: the Dionysos Study. Hepatology 1994;20:1442-9.
    • (1994) Hepatology , vol.20 , pp. 1442-1449
    • Bellentani, S.1    Tiribelli, C.2    Saccoccio, G.3    Sodde, M.4    Fratti, N.5    De Martin, C.6
  • 4
    • 0024981607 scopus 로고
    • Recombinant interferon alfa therapy for chronic hepatitis C. A randomised, double-blind, placebo-controlled trial
    • di Bisceglie AM, Martin P, Kassianides C, Lisker-Melman M, Murray L, Waggoner J, et al. Recombinant interferon alfa therapy for chronic hepatitis C. A randomised, double-blind, placebo-controlled trial. N Engl J Med 1989;321:1506-10.
    • (1989) N Engl J Med , vol.321 , pp. 1506-1510
    • Di Bisceglie, A.M.1    Martin, P.2    Kassianides, C.3    Lisker-Melman, M.4    Murray, L.5    Waggoner, J.6
  • 5
    • 0029054011 scopus 로고
    • A comparison of three interferon alfa-2b regimens for the long-term treatment of chronic non-A, non-B hepatitis
    • Multicenter Study Group
    • Poynard T, Bedossa P, Chevallier M, Mathurin P, Lemonnier C, Trepo C, et al. A comparison of three interferon alfa-2b regimens for the long-term treatment of chronic non-A, non-B hepatitis. Multicenter Study Group. N Engl J Med 1995;332:1457-62.
    • (1995) N Engl J Med , vol.332 , pp. 1457-1462
    • Poynard, T.1    Bedossa, P.2    Chevallier, M.3    Mathurin, P.4    Lemonnier, C.5    Trepo, C.6
  • 6
    • 0029833829 scopus 로고    scopus 로고
    • Meta-analysis of interferon randomized trials in the treatment of viral hepatitis C: Effects of dose and duration
    • Poynard T, Leroy V, Cohard M, Thevenot T, Mathurin P, Opolon P, et al. Meta-analysis of interferon randomized trials in the treatment of viral hepatitis C: effects of dose and duration. Hepatology 1996;24:778-89.
    • (1996) Hepatology , vol.24 , pp. 778-789
    • Poynard, T.1    Leroy, V.2    Cohard, M.3    Thevenot, T.4    Mathurin, P.5    Opolon, P.6
  • 7
    • 0032547938 scopus 로고    scopus 로고
    • Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C
    • Hepatitis Interventional Therapy Group
    • McHutchison JG, Gordon SC, Schiff ER, Shiffman ML, Lee WM, Rustgi VK, et al. Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group. N Engl J Med 1998;339:1485-92.
    • (1998) N Engl J Med , vol.339 , pp. 1485-1492
    • McHutchison, J.G.1    Gordon, S.C.2    Schiff, E.R.3    Shiffman, M.L.4    Lee, W.M.5    Rustgi, V.K.6
  • 8
    • 0034033749 scopus 로고    scopus 로고
    • Combination of ribavirin and interferon-alfa surpasses high doses of interferon-alfa alone in patients with genotype-1b-related chronic hepatitis C
    • Pol S, Nalpas B, Bourliere M, Couzigou P, Tran A, Abergel A, et al. Combination of ribavirin and interferon-alfa surpasses high doses of interferon-alfa alone in patients with genotype-1b-related chronic hepatitis C. Hepatology 2000;31:1338-44.
    • (2000) Hepatology , vol.31 , pp. 1338-1344
    • Pol, S.1    Nalpas, B.2    Bourliere, M.3    Couzigou, P.4    Tran, A.5    Abergel, A.6
  • 9
    • 0032548032 scopus 로고    scopus 로고
    • Combination therapy for hepatitis C infection
    • editorial; comment
    • Liang TJ. Combination therapy for hepatitis C infection. N Engl J Med 1998;339:1549-50 editorial; comment.
    • (1998) N Engl J Med , vol.339 , pp. 1549-1550
    • Liang, T.J.1
  • 10
    • 0028925814 scopus 로고
    • Two-year biochemical, virological, and histological follow-up in patients with chronic hepatitis C responding in a sustained fashion to interferon alfa-2b treatment
    • Reichard O, Glaumann H, Fryden A, Norkrans G, Schvarcz R, Sonnerborg A, et al. Two-year biochemical, virological, and histological follow-up in patients with chronic hepatitis C responding in a sustained fashion to interferon alfa-2b treatment. Hepatology 1995;21:918-22.
    • (1995) Hepatology , vol.21 , pp. 918-922
    • Reichard, O.1    Glaumann, H.2    Fryden, A.3    Norkrans, G.4    Schvarcz, R.5    Sonnerborg, A.6
  • 11
    • 15644380122 scopus 로고    scopus 로고
    • Long-term histologic improvement and loss of detectable intrahepatic HCV RNA in patients with chronic hepatitis C and sustained response to interferon-alpha therapy
    • Marcellin P, Boyer N, Gervais A, Martinot M, Pouteau M, Castelnau C, et al. Long-term histologic improvement and loss of detectable intrahepatic HCV RNA in patients with chronic hepatitis C and sustained response to interferon-alpha therapy. Ann Inter Med 1997;127:875-81.
    • (1997) Ann Inter Med , vol.127 , pp. 875-881
    • Marcellin, P.1    Boyer, N.2    Gervais, A.3    Martinot, M.4    Pouteau, M.5    Castelnau, C.6
  • 12
    • 12644299637 scopus 로고    scopus 로고
    • Relationship between biochemical, virological, and histological response during interferon treatment of chronic hepatitis C
    • Shiffman ML, Hofmann CM, Thompson EB, Ferreira-Gonzalez A, Contos MJ, Koshy A, et al. Relationship between biochemical, virological, and histological response during interferon treatment of chronic hepatitis C. Hepatology 1997;26:780-5.
    • (1997) Hepatology , vol.26 , pp. 780-785
    • Shiffman, M.L.1    Hofmann, C.M.2    Thompson, E.B.3    Ferreira-Gonzalez, A.4    Contos, M.J.5    Koshy, A.6
  • 13
    • 17644441983 scopus 로고
    • Histologic changes in liver biopsy specimens produced by recombinant interferon alpha-2b therapy for chronic non-A, non-B viral hepatitis. A randomized controlled trial
    • David E, Pucci A, Palladin D, Saracco G, Garello E, Pintus C, et al. Histologic changes in liver biopsy specimens produced by recombinant interferon alpha-2b therapy for chronic non-A, non-B viral hepatitis. A randomized controlled trial. Am J Clin Pathol 1992;98:397-401.
    • (1992) Am J Clin Pathol , vol.98 , pp. 397-401
    • David, E.1    Pucci, A.2    Palladin, D.3    Saracco, G.4    Garello, E.5    Pintus, C.6
  • 14
    • 0028284401 scopus 로고
    • Virological and biochemical long-term follow-up of patients with chronic hepatitis C treated with interferon
    • Castillo I, Bartolome J, Navas S, Gonzalez S, Herrero M, Carreno V. Virological and biochemical long-term follow-up of patients with chronic hepatitis C treated with interferon. Hepatology 1994;19:1342-6.
    • (1994) Hepatology , vol.19 , pp. 1342-1346
    • Castillo, I.1    Bartolome, J.2    Navas, S.3    Gonzalez, S.4    Herrero, M.5    Carreno, V.6
  • 16
    • 0030933395 scopus 로고    scopus 로고
    • Natural history of liver fibrosis progression in patients with chronic hepatitis C
    • The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups
    • Poynard T, Bedossa P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Lancet 1997;349:825-32.
    • (1997) Lancet , vol.349 , pp. 825-832
    • Poynard, T.1    Bedossa, P.2    Opolon, P.3
  • 17
    • 0020055254 scopus 로고
    • The hydrophobic-hydrophilic balance of bile salts. Inverse correlation between reverse-phase high performance liquid chromatographic mobilities and micellar cholesterol-solubilizing capacities
    • Armstrong MJ, Carey MC. The hydrophobic-hydrophilic balance of bile salts. Inverse correlation between reverse-phase high performance liquid chromatographic mobilities and micellar cholesterol-solubilizing capacities. J Lipid Res 1982;23:70-80.
    • (1982) J Lipid Res , vol.23 , pp. 70-80
    • Armstrong, M.J.1    Carey, M.C.2
  • 18
    • 0025790578 scopus 로고
    • Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: In vitro studies in rat hepatocytes and human erythrocytes
    • Heuman DM, Pandak WM, Hylemon PB, Vlahcevic ZR. Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: in vitro studies in rat hepatocytes and human erythrocytes. Hepatology 1991;14:920-6.
    • (1991) Hepatology , vol.14 , pp. 920-926
    • Heuman, D.M.1    Pandak, W.M.2    Hylemon, P.B.3    Vlahcevic, Z.R.4
  • 19
    • 0025155478 scopus 로고
    • Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes
    • Galle PR, Theilmann L, Raedsch R, Otto G, Stiehl A. Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes. Hepatology 1990;12:486-91.
    • (1990) Hepatology , vol.12 , pp. 486-491
    • Galle, P.R.1    Theilmann, L.2    Raedsch, R.3    Otto, G.4    Stiehl, A.5
  • 20
    • 0032525819 scopus 로고    scopus 로고
    • A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation
    • Rodrigues CM, Fan G, Ma X, Kren BT, Steer CJ. A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. J Clin Invest 1998;101:2790-9.
    • (1998) J Clin Invest , vol.101 , pp. 2790-2799
    • Rodrigues, C.M.1    Fan, G.2    Ma, X.3    Kren, B.T.4    Steer, C.J.5
  • 21
    • 0031911131 scopus 로고    scopus 로고
    • Effect of tauroursodeoxycholic acid on bile-acid-induced apoptosis and cytolysis in rat hepatocytes
    • Benz C, Angermuller S, Tox U, Kloters-Plachky P, Riedel HD, Sauer P, et al. Effect of tauroursodeoxycholic acid on bile-acid-induced apoptosis and cytolysis in rat hepatocytes. J Hepatol 1998;28:99-106.
    • (1998) J Hepatol , vol.28 , pp. 99-106
    • Benz, C.1    Angermuller, S.2    Tox, U.3    Kloters-Plachky, P.4    Riedel, H.D.5    Sauer, P.6
  • 22
    • 0025876404 scopus 로고
    • A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis
    • UDCA-PBC Study Group
    • Poupon RE, Balkau B, Eschwege E, Poupon R. A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC Study Group. N Engl J Med 1991;324:1548-54.
    • (1991) N Engl J Med , vol.324 , pp. 1548-1554
    • Poupon, R.E.1    Balkau, B.2    Eschwege, E.3    Poupon, R.4
  • 23
    • 0028346255 scopus 로고
    • The Canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis
    • Heathcote EJ, Cauch-Dudek K, Walker V, Bailey RJ, Blendis LM, Ghent CN, et al. The Canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1994;19:1149-56.
    • (1994) Hepatology , vol.19 , pp. 1149-1156
    • Heathcote, E.J.1    Cauch-Dudek, K.2    Walker, V.3    Bailey, R.J.4    Blendis, L.M.5    Ghent, C.N.6
  • 25
    • 0025257161 scopus 로고
    • Effects of ursodeoxycholic acid and taurine on serum liver enzymes and bile acids in chronic hepatitis
    • Podda M, Ghezzi C, Battezzati PM, Crosignani A, Zuin M, Roda A. Effects of ursodeoxycholic acid and taurine on serum liver enzymes and bile acids in chronic hepatitis. Gastroenterology 1990;98:1044-50.
    • (1990) Gastroenterology , vol.98 , pp. 1044-1050
    • Podda, M.1    Ghezzi, C.2    Battezzati, P.M.3    Crosignani, A.4    Zuin, M.5    Roda, A.6
  • 26
    • 0026062522 scopus 로고
    • Effects of ursodeoxycholic acid on serum liver enzymes and bile acid metabolism in chronic active hepatitis: A dose-response study
    • Crosignani A, Battezzati PM, Setchell KD, Camisasca M, Bertolini E, Roda A, et al. Effects of ursodeoxycholic acid on serum liver enzymes and bile acid metabolism in chronic active hepatitis: a dose-response study. Hepatology 1991;13:339-44.
    • (1991) Hepatology , vol.13 , pp. 339-344
    • Crosignani, A.1    Battezzati, P.M.2    Setchell, K.D.3    Camisasca, M.4    Bertolini, E.5    Roda, A.6
  • 27
    • 0028293869 scopus 로고
    • Ursodeoxycholic therapy in chronic liver disease: A meta-analysis in primary biliary cirrhosis and in chronic hepatitis
    • Simko V, Michael S, Prego V. Ursodeoxycholic therapy in chronic liver disease: a meta-analysis in primary biliary cirrhosis and in chronic hepatitis. Am J Gastroenterol 1994;89:392-8.
    • (1994) Am J Gastroenterol , vol.89 , pp. 392-398
    • Simko, V.1    Michael, S.2    Prego, V.3
  • 28
    • 0029891114 scopus 로고    scopus 로고
    • Effect of ursodeoxycholic acid on HCV replication in subtyped chronic hepatitis C
    • letter
    • Mohler M, Seipp S, Tox U, Stremmel W, Theilmann L, Goeser T. Effect of ursodeoxycholic acid on HCV replication in subtyped chronic hepatitis C. Dig Dis Sci 1996;41:1276-7 letter.
    • (1996) Dig Dis Sci , vol.41 , pp. 1276-1277
    • Mohler, M.1    Seipp, S.2    Tox, U.3    Stremmel, W.4    Theilmann, L.5    Goeser, T.6
  • 29
    • 0030761870 scopus 로고    scopus 로고
    • Interferon plus ursodeoxycholic acid versus interferon in the treatment of chronic C viral hepatitis
    • Clerici C, Distrutti E, Gentili G, Solinas A, Miglietti M, Balo S, et al. Interferon plus ursodeoxycholic acid versus interferon in the treatment of chronic C viral hepatitis. Minerva Med 1997;88:219-25.
    • (1997) Minerva Med , vol.88 , pp. 219-225
    • Clerici, C.1    Distrutti, E.2    Gentili, G.3    Solinas, A.4    Miglietti, M.5    Balo, S.6
  • 30
    • 8044245916 scopus 로고    scopus 로고
    • Efficacy of combination therapy of interferon-alpha with ursodeoxycholic acid in chronic hepatitis C: A randomized controlled clinical trial
    • Kiso S, Kawata S, Tamura S, Imai Y, Inui Y, Nagase T, et al. Efficacy of combination therapy of interferon-alpha with ursodeoxycholic acid in chronic hepatitis C: a randomized controlled clinical trial. J Gastroenterol 1997;32:56-62.
    • (1997) J Gastroenterol , vol.32 , pp. 56-62
    • Kiso, S.1    Kawata, S.2    Tamura, S.3    Imai, Y.4    Inui, Y.5    Nagase, T.6
  • 31
    • 0028960364 scopus 로고
    • Interferon and ursodeoxycholic acid combined therapy in the treatment of chronic viral C hepatitis: Results from a controlled randomized trial in 80 patients
    • Boucher E, Jouanolle H, Andre P, Ruffault A, Guyader D, Moirand R, et al. Interferon and ursodeoxycholic acid combined therapy in the treatment of chronic viral C hepatitis: results from a controlled randomized trial in 80 patients. Hepatology 1995;21:322-7.
    • (1995) Hepatology , vol.21 , pp. 322-327
    • Boucher, E.1    Jouanolle, H.2    Andre, P.3    Ruffault, A.4    Guyader, D.5    Moirand, R.6
  • 32
    • 0030482377 scopus 로고    scopus 로고
    • Efficacy of ursodeoxycholic acid in combination with interferon-alpha in treating chronic hepatitis C: Results of a long-term follow-up trial
    • Tanaka K, Kondo M, Sakaguchi T, Saito S, Arata S, Ikeda M, et al. Efficacy of ursodeoxycholic acid in combination with interferon-alpha in treating chronic hepatitis C: results of a long-term follow-up trial. J Gastroenterol Hepatol 1996;11:1155-60.
    • (1996) J Gastroenterol Hepatol , vol.11 , pp. 1155-1160
    • Tanaka, K.1    Kondo, M.2    Sakaguchi, T.3    Saito, S.4    Arata, S.5    Ikeda, M.6
  • 33
    • 0034076164 scopus 로고    scopus 로고
    • Efficacy of ursodeoxycholic acid in association with alpha-interferon for chronic hepatitis C in alpha-interferon non-responder patients
    • Fabbri C, Marchetto S, Pezzoli A, Accogli E, Fusaroli P, Azzaroli F, et al. Efficacy of ursodeoxycholic acid in association with alpha-interferon for chronic hepatitis C in alpha-interferon non-responder patients. Eur J Gastroenterol Hepatol 2000;12:511-5.
    • (2000) Eur J Gastroenterol Hepatol , vol.12 , pp. 511-515
    • Fabbri, C.1    Marchetto, S.2    Pezzoli, A.3    Accogli, E.4    Fusaroli, P.5    Azzaroli, F.6
  • 35
    • 0028814835 scopus 로고
    • Recombinant interferon-alpha and ursodeoxycholic acid versus interferon-alpha alone in the treatment of chronic hepatitis C: A randomized clinical trial with long-term follow-up
    • Angelico M, Gandin C, Pescarmona E, Rapicetta M, Del Vecchio C, Bini A, et al. Recombinant interferon-alpha and ursodeoxycholic acid versus interferon-alpha alone in the treatment of chronic hepatitis C: a randomized clinical trial with long-term follow-up. Am J Gastroenterol 1995;90:263-9.
    • (1995) Am J Gastroenterol , vol.90 , pp. 263-269
    • Angelico, M.1    Gandin, C.2    Pescarmona, E.3    Rapicetta, M.4    Del Vecchio, C.5    Bini, A.6
  • 36
    • 0019813866 scopus 로고
    • Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
    • Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981;1:431-5.
    • (1981) Hepatology , vol.1 , pp. 431-435
    • Knodell, R.G.1    Ishak, K.G.2    Black, W.C.3    Chen, T.S.4    Craig, R.5    Kaplowitz, N.6
  • 39
    • 12944259215 scopus 로고    scopus 로고
    • Interferon and ursodeoxycholic acid combined therapy in chronic viral C hepatitis: Controlled randomized trial in 203 patients
    • Boucher E, Guyader D, Jacquelinet S, Andre P, Mendler MH, Turlin B, et al. Interferon and ursodeoxycholic acid combined therapy in chronic viral C hepatitis: controlled randomized trial in 203 patients. Dig Liver Dis 2000;32:29-33.
    • (2000) Dig Liver Dis , vol.32 , pp. 29-33
    • Boucher, E.1    Guyader, D.2    Jacquelinet, S.3    Andre, P.4    Mendler, M.H.5    Turlin, B.6
  • 40
    • 0032736213 scopus 로고    scopus 로고
    • A randomised, controlled trial of maintenance interferon therapy for patients with chronic hepatitis C virus and persistent viremia
    • Shiffman ML, Hofmann CM, Contos MJ, Luketic VA, Sanyal AJ, Sterling RK, et al. A randomised, controlled trial of maintenance interferon therapy for patients with chronic hepatitis C virus and persistent viremia. Gastroenterology 1999;117:1164-72.
    • (1999) Gastroenterology , vol.117 , pp. 1164-1172
    • Shiffman, M.L.1    Hofmann, C.M.2    Contos, M.J.3    Luketic, V.A.4    Sanyal, A.J.5    Sterling, R.K.6
  • 41
    • 0028876148 scopus 로고
    • Efficacy of interferon alfa therapy in chronic hepatitis C patients depends primarily on hepatitis C virus RNA level
    • Yamada G, Takatani M, Kishi F, Takahashi M, Doi T, Tsuji T, et al. Efficacy of interferon alfa therapy in chronic hepatitis C patients depends primarily on hepatitis C virus RNA level. Hepatology 1995;22:1351-4.
    • (1995) Hepatology , vol.22 , pp. 1351-1354
    • Yamada, G.1    Takatani, M.2    Kishi, F.3    Takahashi, M.4    Doi, T.5    Tsuji, T.6
  • 43
    • 17844403232 scopus 로고    scopus 로고
    • A randomized, double-blind trial comparing pegylated interferon alfa-2b to interferon alfa-2b as initial treatment for chronic hepatitis C
    • Lindsay KL, Trepo C, Heintges T, Shiffman ML, Gordon SC, Hoefs JC, et al. A randomized, double-blind trial comparing pegylated interferon alfa-2b to interferon alfa-2b as initial treatment for chronic hepatitis C. Hepatology 2001;34:395-403.
    • (2001) Hepatology , vol.34 , pp. 395-403
    • Lindsay, K.L.1    Trepo, C.2    Heintges, T.3    Shiffman, M.L.4    Gordon, S.C.5    Hoefs, J.C.6
  • 44
    • 0027386603 scopus 로고
    • Pathological diagnosis of chronic hepatitis C: A multicenter comparative study with chronic hepatitis B
    • The Hepatitis Interventional Therapy Group
    • Lefkowitch JH, Schiff ER, Davis GL, Perrillo RP, Lindsay K, Bodenheimer HC Jr., et al. Pathological diagnosis of chronic hepatitis C: a multicenter comparative study with chronic hepatitis B. The Hepatitis Interventional Therapy Group. Gastroenterology 1993;104:595-603.
    • (1993) Gastroenterology , vol.104 , pp. 595-603
    • Lefkowitch, J.H.1    Schiff, E.R.2    Davis, G.L.3    Perrillo, R.P.4    Lindsay, K.5    Bodenheimer Jr., H.C.6
  • 45
    • 0028958795 scopus 로고
    • Effect of cholestasis and bile acids on interferon-induced 2′,5′-adenylate synthetase and NK cell activities
    • Podevin P, Calmus Y, Bonnefis MT, Veyrunes C, Chereau C, Poupon R. Effect of cholestasis and bile acids on interferon-induced 2′,5′-adenylate synthetase and NK cell activities. Gastroenterology 1995;108:1192-8.
    • (1995) Gastroenterology , vol.108 , pp. 1192-1198
    • Podevin, P.1    Calmus, Y.2    Bonnefis, M.T.3    Veyrunes, C.4    Chereau, C.5    Poupon, R.6
  • 46
    • 0028294206 scopus 로고
    • Ursodiol for the long-term treatment of primary biliary cirrhosis
    • The UDCA-PBC Study Group
    • Poupon RE, Poupon R, Balkau B. Ursodiol for the long-term treatment of primary biliary cirrhosis. The UDCA-PBC Study Group. N Engl J Med 1994;330:1342-7.
    • (1994) N Engl J Med , vol.330 , pp. 1342-1347
    • Poupon, R.E.1    Poupon, R.2    Balkau, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.