Hyperoxia-induced improvement of the in vitro response to gemcitabine in transitional cell carcinoma

Anticancer Research

Volumn 25, Issue 5, 2005, Pages 3413-3418

  Fechner, Guido ^a   Dederichs, Frank ^a   Schmidt, Doris ^a   Müller, Stefan ^a   Vaupel, Peter ^b   Albers, Peter ^c  

^a UNIVERSITY OF BONN   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c KLINIKUM KASSEL   (Germany)

Author keywords

Bladder cancer; Gemcitabine; Hypoxia

Indexed keywords

EPIDERMAL GROWTH FACTOR; GEMCITABINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; VASCULOTROPIN;

ANEMIA; ANGIOGENESIS; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER INVASION; CELL ASSAY; CELL PROLIFERATION; CELL STRAIN RT112; CELL STRAIN RT4; CELL STRAIN T24; CELL STRAIN TCC SUP; CELL SURVIVAL; CONTROLLED STUDY; DRUG RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYPEROXIA; HYPOXEMIA; IN VITRO STUDY; MICROCULTURE TETRAZOLIUM ASSAY; MONOLAYER CULTURE; PRIORITY JOURNAL; TRANSITIONAL CELL CARCINOMA; WESTERN BLOTTING;

ANTIMETABOLITES, ANTINEOPLASTIC; BLOTTING, WESTERN; CARCINOMA, TRANSITIONAL CELL; CELL GROWTH PROCESSES; CELL HYPOXIA; CELL SURVIVAL; DEOXYCYTIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; OXYGEN; TRANSCRIPTION FACTORS; URINARY BLADDER NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 23444445853     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Molls M, Stadler P, Backer A, Feldmann HJ and Dunst J: Relevance of oxygen in radiation oncology. Mechanisms of action, correlation to low hemoglobin levels. Strahlenther Onkol 174 Suppl 4: 13-16, 1998.
2. Kelleher DK, Thews O and Vaupel P: Can erythropoietin improve tumor oxygenation? Strahlenther Onkol 174 Suppl 4: 20-23, 1998.
3. Teicher BA, Lazo JS and Sartorelli AC: Classification of antineoplastic treatments by their differential toxicities toward oxygenated and hypoxic tumor cells. Cancer Res 41: 73-81, 1991.
4. Teicher BA, Ara G, Hernst R, Tekeuchi H, Keyes S and Northey D: PEG-hemoglobin: effects on tumor oxygenation and response to chemotherapy. In Vivo 11: 301-311, 1997.
5. Graham CH, Forsdike J, Fitzgerald CJ and Macdonald-Goodfellow S: Hypoxia-mediated stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression. Int J Cancer 80: 617-623, 1999.
6. Brizel DM, Scully SP, Harrelson JM, Layfield LJ, Ean JM and Prosnitz LR: Tumor oxygenation predicts the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 56: 941-943, 1996.
7. Vaupel P, Thews O and Hoeckel M: Treatment resistance of solid tumors. Med Oncol 18: 243-259, 2001.
8. von der Maase H, Hansen SW, Roberts JT, Dogliotti L, Oliver T, Moore MJ, Bodrogi I, Albers P, Knuth A, Lippert CM, Kerbrat P, Sanchez Rovira P, Wersall P, Cleall SP, Roychowdhury DF, Tomlin I, Visseren-Grul CM and Conte PF: Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study. J Clin Oncol 18(17): 3068-3077, 2000.
9. Turner KJ, Crew JP, Wykoff CC, Watson PH, Poulsom R, Pastorek J, Ratcliffe PJ, Cranston D and Harris AL: The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer. Br J Cancer 22;86: 1276-1282, 2002.
10. Xia G, Kageyama Y, Hayashi T, Hyochi N, Kawakami S and Kihara K: Positive expression of HIF-2alpha/EPAS1 in invasive bladder cancer. Urology 59: 774-778, 2002.
11. Musallam L, Ethier C, Haddad PS and Bilodeau M: EGF mediates protection against Fas-induced apoptosis by depleting and oxidizing intracellular GSH stocks. J Cell Physiol 198: 62-72, 2004.
12. Bergman AM, Pinedo HM and Peters GJ: Determinants of resistance to 2′,2′-difluorodeoxycytidine (gemcitabine). Drug Resist Update 5: 19-33, 2002.
13. Felderhoff-Mueser U, Sifringer M, Policy O, Dzietko M, Leineweber B, Mahler L, Baier M, Bittigau P, Obladen M, Ikonomidou C and Buhrer C: Caspase-1-processed interleukins in hyperoxia-induced cell death in the developing brain. Ann Neurol 57(1): 50-59, 2005.
14. Brafman A, Mett I, Shafir M, Gottlieb H, Damari G, Gozlan-Kelner S, Vishnevskia-Dai V, Skaliter R, Einat P, Faerman A, Feinstein E and Shoshani T: Inhibition of oxygen-induced retinopathy in RTP801-deficient mice. Invest Ophthalmol Vis Sci 45(10): 3796-3805, 2004.
15. Pagano A and Barazzone-Argiroffo C: Alveolar cell death in hyperoxia-induced lung injury. Ann NY Acad Sci 1010: 405-416, 2003.