Contrasting loxapine to its isomer isoloxapine - The critical role of in vivo D2 blockade in determining atypicality

Schizophrenia Research

Volumn 77, Issue 2-3, 2005, Pages 189-199

  Natesan, Sridhar ^a   VanderSpek, Suzi ^a   Nobrega, José N ^a,c   McClelland, Robert A ^b   Kapur, Shitij ^a,b  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

5 HT2 D2 occupancy; Antipsychotics; Catalepsy; Conditioned avoidance response; FOS expression; Prolactin

Indexed keywords

ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; ATYPICAL ANTIPSYCHOTIC AGENT; DOPAMINE 2 RECEPTOR; ISOLOXAPINE; LOXAPINE; PROLACTIN; PROTEIN FOS; SEROTONIN 2 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AVOIDANCE BEHAVIOR; CATALEPSY; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; FEMALE; ISOMER; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BLOCKING;

ANIMALS; ANTIPSYCHOTIC AGENTS; AVOIDANCE LEARNING; CATALEPSY; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; LOXAPINE; MALE; PROLACTIN; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2;

EID: 23444439969     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2005.03.009     Document Type: Article

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