Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 17, 2004, Pages 6450-6455

  Jemth, Per ^a   Gianni, Stefano ^a   Day, Ryan ^b   Li, Bin ^b   Johnson, Christopher M ^a   Daggett, Valerie ^b   Fersht, Alan R ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

FF domain; Folding intermediate; Helix bundle; Molecular dynamics

Indexed keywords

PROTEIN; PROTEIN FBP11; PROTEIN HYPA; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; ENERGY; HUMAN; KINETICS; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN ISOLATION; SIMULATION;

KINETICS; PROTEIN ENGINEERING; PROTEIN FOLDING;

MUS;

EID: 2342655032     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0401732101     Document Type: Article

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