Characteristics of drug-release in vitro of different dextran-dexamethasone conjugates

Yaoxue Xuebao

Volumn 38, Issue 5, 2003, Pages 388-391

  Zhou, Si Yuan ^a   Mei, Qi Bing ^a   Liu, Li ^a   Zhang, Bang Le ^a   Li, Chen ^a   Zhou, Jin ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Colon specific drug; Dexamethasone; Dextran; Drug release characteristics

Indexed keywords

DEXAMETHASONE; DEXTRAN; DRUG CARRIER;

ANIMAL; ARTICLE; CHEMISTRY; COLON; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FEMALE; IN VITRO STUDY; MALE; METABOLISM; MOLECULAR WEIGHT; RAT; SMALL INTESTINE; SPRAGUE DAWLEY RAT; STOMACH;

ANIMALS; COLON; DEXAMETHASONE; DEXTRANS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; FEMALE; INTESTINE, SMALL; MALE; MOLECULAR WEIGHT; RATS; RATS, SPRAGUE-DAWLEY; STOMACH;

EID: 2342652387     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Nolen HW, Fedorak RN, Friend DR. Budesonide-β-D-glucuronide: A potential prodrug for treatment of ulcerative colitis [J]. J Pharm Sci, 1995,84(6):677-681.
2. Wilding IR, Davis SS, Pozzi F, et al. Enteric coated timed release systems for colonic targeting [J]. Int J Pharm, 1994,111(1):99- 102.
3. Jung YJ, Lee JS, Kim YM. Colon-specific prodrugs of 5-aminosalicylic acid: synthesis and in vitro/in vivo properties of acidic amino acid derivatives of 5-aminosalicylic acid [J]. J Pharm Sci, 2001,90(11):1767-1775.
4. Zhou SY, Mei QB, Zhou J, et al. Pharmacokinetics of site-specific delivery of dexamethasone-dextran prodrug in rat gastrointestinal tract [J]. Acta Pharm Sin, 2001,36(5):325-328.
5. Rodriguez M, Antunez JA, Taboada C, et al. Colon-specific delivery of budesonide from microencapsulated cellulosic cores: evaluation of the efficacy against colonic inflammation in rats [J]. J Pharm Pharmacol, 2001,53(9):1207-1215.
6. Muraoka M, Hu Z, Shimokawa T, et al. Evaluation of intestinal pressure-controlled colon delivery capsule containing caffeine as a model drug in human volunteers [J]. J Controlled Release, 1998,52(1/2):119- 129.
7. Pang YN, Zhang ZR, Pang QJ, et al. Study on the enzyme dependent colon targeting prodrug-dexamethasone succinate dextran and its tablets [J]. Acta Pharm Sin, 2001,36(8):625-630.
8. Zhou SY, Mei QB, Zhao DH. Synthesis and delivery characteristics of colon-specific dexamethasone prodrug [J]. J Med Coll PLA, 2000,15(2):91-93.
9. McLeod AD, Friend DR, Tozer TN. Synthesis and chemical stability of glucocorticoid-dextran esters: potential prodrugs for colon-specific delivery [J]. Int J Pharm, 1993,92(2):105-114.
10. Zhou J, Mei QB, LI P, et al. Colon-specific delivery release mechanism of prednisolone-dextran prodrug [J]. Chin Pharmacol Bull, 2002,18(3):328-330.