Antithrombotic effects of morpholine and piperazine ring derivatives and their molecular mechanism

Yaoxue Xuebao

Volumn 38, Issue 9, 2003, Pages 641-645

  Chen, Dong Mei ^a   Chen, Kai ^a   Wang, Hai ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

Acetylcholine; Carrageenin; Endothelial cell; Thrombosis

Indexed keywords

FIBRINOLYTIC AGENT; MORPHOLINE; MORPHOLINE DERIVATIVE; PIPERAZINE; PIPERAZINE DERIVATIVE; PLASMINOGEN ACTIVATOR INHIBITOR 1; TISSUE PLASMINOGEN ACTIVATOR; VASODILATOR AGENT;

ANIMAL; ARTICLE; DRUG EFFECT; FEMALE; MALE; METABOLISM; MOUSE; RAT; THORACIC AORTA; THROMBOCYTE AGGREGATION; VASCULAR ENDOTHELIUM; WISTAR RAT;

ANIMALS; AORTA, THORACIC; ENDOTHELIUM, VASCULAR; FEMALE; FIBRINOLYTIC AGENTS; MALE; MICE; MORPHOLINES; PIPERAZINES; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLATELET AGGREGATION; RATS; RATS, WISTAR; TISSUE PLASMINOGEN ACTIVATOR; VASODILATOR AGENTS;

EID: 2342642222     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Key NS. Scratching the surface: endothelium as a regulator of thrombosis, fibrinolysis, and inflammation [J]. J Lab Clin Med, 1992,120(2): 184-186.
2. Gross PL, Aird WC. The endothelium and thrombosis [J]. Semin Thromb Hemost, 2000,26(5):463-478.
3. Raitakari OT, Celermajer DS. Testing for endothelial dysfunction [J]. Ann Med, 2000,32(5):293-304.
4. Dawson S, Henney A. The status of PAI-1 as a risk factor for arterial andthrombotic disease: a review [J]. Atherosclerosis, 1992,95(2):105-117.
5. Holvoet P, Collen D. Oxidized lipoproteins in atherosclerosis and thrombosis [J]. FASEB, 1994,8(15):1279-1284.
6. Boulanger CM. Endothelial dysfunction:a novel therapeutic target. Secondary endothelial dysfunction:hypertension and heart failure [J]. J Mol Cell Cardiol, 1999,31(1):39-49.
7. Shimokawa H. Endothelial dysfunction:a novel therapeutic target. Primary endothelial dysfunction:atherosclerosis [J]. J Mol Cell Cardiol, 1999,31(1):23-37.
8. Nene S, Gelabert HA, Moore WS, et al. Exposure to thrombus diminishes endothelial derived relaxation in the rabbit carotid artery [J]. J Surg Res, 1999,87(1):51-56.
9. Reil TD, Moore WS, Kashyap VS. The effects of thrombosis, thrombectomy and thrombolysis on endothelial function [J]. Eur J Vas Endovasc Surg, 2000,199(2):162 -168.
10. Feletou M, Vanhoutte PM. Endothelium-dependent hyperpolarization of canine coronary smooth muscle [J]. Br J Pharmacol, 1988,93(3):515- 524.
11. Bekemeier H, Hirschelmann R, Giessler AJ. Carrageenin-induced thrombosis in the rat and mouse as a test model of substances influencing thrombosis [J]. Biomed Biochim Acta, 1984,43(3):347-350.
12. Li MS, Hai W. Pharmacological characteristics of the endothelial target for acetylcholine [J]. Life Sci., 2002,70 (11):1285-1298.
13. Chen DM, Mu SF, Wang H. Antithrombosis through activating endothelial target for acetylcholine and its molecular mechanism [J]. Chin Pharmacol Bull, 2002,18(5):527-531.