Antithrombosis through activating endothelial target for acetylcholine and its molecular mechanism

Chinese Pharmacological Bulletin

Volumn 18, Issue 5, 2002, Pages 527-531

  Chen, Dong Mei ^a   Mu, Shao Feng ^a   Wang, Hai ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

Acetylcholine; Arecoline; Carrageenin; Endothelium; PAI 1; T PA; Thrombosis

Indexed keywords

ACETYLCHOLINE; ACETYLSALICYLIC ACID; ARECOLINE; CARRAGEENAN; MUSCARINIC RECEPTOR; PILOCARPINE; PLASMINOGEN ACTIVATOR INHIBITOR; PROTHROMBIN; THROMBIN; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY THROMBOSIS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; HEMOSTASIS; MALE; MOUSE; NONHUMAN; THROMBOCYTE AGGREGATION; VASCULAR ENDOTHELIUM;

EID: 0036816323     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288(5789):373-6
2. Sagripanti A, Carpi A. Antithrombotic and prothrombotic activities of the vascular endothelium. Biomed Pharmacother, 2000;54(2): 107-11
3. Rosenberg RD, Aird WC. Vascular-bed-specific hemostasis and hypercoagulable states. N Engl J Med, 1999;340(20):1555-64
4. Repo H, Harlan JM. Mechanisms and consequences of phagocyte adhesion to endothelium. Ann Med, 1999;31(3):156-65
5. Cines DB, Pollak ES, Buck CA. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood, 1998;91(10): 3527-61
6. Gross P, Aird WC. The endothelium and thrombosis. Seminars in Thrombosis and Hemostasis, 2000;26(5):463-78
7. Zollner S, Aberle S, Harvey SE. Changes of endothelial nitric oxide synthase level and activity during endothelial cell proliferation. Endothelium, 2000;7(3):169-84
8. Raitakari OT, Celermajer DS. Testing for endothelial dysfunction. Ann Med, 2000;32(5):293-304
9. Shan LM, Wang H. Pharmacological characteristics of the endothelial target for acetylcholine. Life Sci, 2002;70(11):1285-98