Psoriasis is not associated with IL-12p70/IL-12p40 production and IL12B promoter polymorphism

Journal of Investigative Dermatology

Volumn 122, Issue 4, 2004, Pages 923-926

  Litjens, Nicolle H R ^a   Van Der Plas, Mariena J A ^a   Ravensbergen, Bep ^a   Numan Ruberg, Sandra C ^a   Van Assen, Yvette ^b   Thio, H Bing ^b   Van Dissel, Jaap T ^a   Van Vosse, Esther De ^a   Nibbering, Peter H ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Blood cells; IL12B promoter polymorphism; Interleukin 12; Psoriasis

Indexed keywords

INTERLEUKIN 12; LIPOPOLYSACCHARIDE; PROTEIN P40;

ARTICLE; BLOOD CELL; CELL STIMULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA POLYMORPHISM; GENE FREQUENCY; GENETIC CODE; GENOTYPE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PSORIASIS; STATISTICAL SIGNIFICANCE; VOLUNTEER;

EID: 2342631378     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.22427.x     Document Type: Article

References (17)

1. Asadullah K, Eskdale J, Wiese A, Gallagher G, Friedrich M, Sterry W: Interleukin-10 promoter polymorphism in psoriasis. J Invest Dermatol 116:975-878, 2001
2. Austin LM, Ozawa M, Kikuchi T, Walters IB, Krueger JG: The majority of epidermal T-cells in psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: 1 A type 1 differentiation bias is also measured in circulating blood T-cells in psoriatic patients. J Invest Dermatol 113:752-759, 1999
3. Bos JD, De Rie MA: The pathogenesis of psoriasis: Immunological facts and speculations. Immunol Today 20:40-46, 1999
4. Bouter H, Schippers EF, Luelmo SA, et al: No effect of preoperative selective gut decontamination on endotoxemia and cytokine activation during cardiopulmonary bypass: A randomized, placebo-controlled study. Crit Care Med 30:38-43, 2002
5. Cheng J, Tu Y, Li J, Huang C, Liu Z, Liu D: A study on the expression of interleukin (IL)-10 and IL-12 P35, P40 mRNA in the psoriatic lesions. J Tongji Med Univ 21:86-88, 2001
6. Economidou J, Barkis J, Demetriou Z: Effects of cyclosporin A on immune activation markers in patients with active psoriasis. Dermatology 199:144-148, 1999
7. Hall MA, McGlinn E, Coakley G, et al: Genetic polymorphism of IL-12 p40 gene in immune-mediated disease. Genes Immun 1:219-224, 2000
8. Morahan G, Huang D, Wu M, et al: Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children. Lancet 360:455-459, 2002
9. Nestle FO, Turka LA, Nickoloff BJ: Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines. J Clin Invest 94:202-209, 1994
10. Nickoloff BJ: Skin innate immune system in psoriasl: Friend or foe? J Clin Invest 104:1161-1164, 1999
11. Reich K, Mossner R, Konig IR, Westphal G, Ziegler A, Neumann C: Promoter polymorphisms of the genes encoding tumor necrosis factor-alpha and interleukin-1beta are associated with different subtypes of psoriasis characterized by early and late disease onset. J Invest Dermatol 118: 155-163, 2002
12. Schlaak JF, Buslau M, Jochem W: T-cells involved in psoriasis belong to the TH1 subset. J Invest Dermatol 102:145-149, 1994
13. Stuart P, Malick F, Nair RP, et al: Analysis of phenotypic variation in psoriasis as a function of age at onset and family history. Arch Dermatol Res 294:207-213, 2002
14. Trinchieri G: Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3:133-146, 2003
15. Tsunemi Y, Saeki H, Nakamura K, et al: Interleukin-12 p40 gene (IL12B) 3′-untranslated region polymorphism is associated with susceptibility to atopic dermatitis and psoriasis vulgaris. J Dermatol Sci 30:161-166, 2002
16. Uyemura K, Yamamura M, Fivenson DF: The cytokine network in lesional and lesional-free psoriatic skin is characterized by a T helper type 1 cell-mediated response. J Invest Dermatol 101:701-705, 1993
17. Warrington JA, Bengtsson U: High-resolution physical mapping of human 5q31-q33 using three methods: Radiation hybrid mapping, interphase fluorescence in situ hybridization, and pulsed-field gel electrophoresis. Genomics 24:395s-396s, 1994