Input Resistance Is Voltage Dependent Due to Activation of Ih Channels in Rat CA1 Pyramidal Cells

Journal of Neuroscience Research

Volumn 76, Issue 4, 2004, Pages 475-480

  Surges, Rainer ^a,b   Freiman, Thomas M ^a   Feuerstein, Thomas J ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b Sect of Clinical Neuropharmacology   (Germany)

Author keywords

Gabapentin; HCN channels; Hyperpolarization activated cation current; Intrinsic membrane properties; ZD7288

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; CATION CHANNEL; GABAPENTIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; FEMALE; HYPERPOLARIZATION; ION CURRENT; MALE; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT;

4-AMINOPYRIDINE; ACETIC ACIDS; AMINES; ANIMALS; ANIMALS, NEWBORN; CALCIUM CHANNEL BLOCKERS; CYCLOHEXANECARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRIC IMPEDANCE; ELECTRIC STIMULATION; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; ION CHANNEL GATING; ION CHANNELS; MEMBRANE POTENTIALS; NICKEL; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; PYRAMIDAL CELLS; PYRIMIDINES; RATS; RATS, WISTAR; TETRODOTOXIN;

EID: 2342630046     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20075     Document Type: Article

References (20)

1. + channel: differential contribution by two discrete residues. J Physiol 534:381-393.
2. Azouz R, Alroy G, Yaari Y. 1997. Modulation of endogenous firing patterns by osmolarity in rat hippocampal neurones. J Physiol 502:175-187.
3. Chen K, Aradi I, Thon N, Eghbal-Ahmadi M, Baram TZ, Soltesz I. 2001. Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nat Med 7:331-337.
4. Fernandez N, Andreasen M, Nedergaard S. 2002. Influence of the hyperpolarization-activated cation current, I(h), on the electrotonic properties of the distal apical dendrites of hippocampal CA1 pyramidal neurones. Brain Res 930:42-52.
5. Fisahn A, Yamada M, Duttaroy A, Gan JW, Deng CX, McBain CJ, Wess J. 2002. Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents. Neuron 33:615-624.
6. Gasparini S, DiFrancesco D. 1997. Action of the hyperpolarization-activated current (Ih) blocker ZD.7288 in hippocampal CA1 neurons. Pflugers Arch 435:99-106.
7. + current in rat hippocampal pyramidal cells. J Physiol 545:783-805.
8. h channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices. Naunym Schiedebergs Arch Pharmacol 367:422-425.
9. Lorincz A, Notomi T, Tamas G, Shigemoto R, Nusser Z. 2002. Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites. Nat Neurosci 5:1185-1193.
10. Maccaferri G, Mangoni M, Lazzari A, DiFrancesco D. 1993. Properties of the hyperpolarization-activated current in rat hippocampal CA1 pyramidal cells. J Neurophysiol 69:2129-2136.
11. Magee JC. 1998. Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons. J Neurosci 18:7613-7624.
12. h normalizes temporal summation in hippocampal CA1 neurons. Nat Neurosci 2:508-514.
13. Pape HC. 1996. Queer current and pacemaker: the hyperpolarization-activated cation current in neurons. Annu Rev Physiol 58:299-327.
14. Poolos NP, Migliore M, Johnston D. 2002. Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites. Nat Neurosci 5:767-774.
15. Scott RH, Martin DJ, McClelland D. 2003. Cellular actions of gabapentin and related compounds on cultured sensory neurones. Curr Neuropharmacol 1:219-235.
16. Southan AP, Morris NP, Stephens GJ, Robertson B. 2000. Hyperpolarization-activated currents in presynaptic terminals of mouse cerebellar basket cells. J Physiol 526:91-97.
17. Surges R, Feuerstein TJ. 2002. Mode of action of gabapentin in chronic neuropathic pain syndromes. A short review about its cellular mechanisms in nociceptive neurotransmission. Arzneimittelforschung 52:583-586.
18. h in rat CA1 pyramidal cells. Neurosci Lett 332:136-140.
19. h in CA1 pyramidal cells of rat hippocampus. Epilepsia 44:150-156.
20. +. J Physiol 526:231-240.