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Volumn 14, Issue 3, 2004, Pages 143-149

Update on chemoprevention of prostate cancer

Author keywords

Chemoprevention; Finasteride; Lycopene; Prevention; Prostate cancer; Selenium; Soy; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANDROGEN; ANDROSTANOLONE; ANTIOXIDANT; BICALUTAMIDE; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DUTASTERIDE; FINASTERIDE; LYCOPENE; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; OMEGA 3 FATTY ACID; PROSTATE SPECIFIC ANTIGEN; ROFECOXIB; SELENIUM; SELENOMETHIONINE; STEROID 5ALPHA REDUCTASE; STEROID 5ALPHA REDUCTASE INHIBITOR; TRACE ELEMENT; VITAMIN D;

EID: 2342626088     PISSN: 09630643     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042307-200405000-00002     Document Type: Review
Times cited : (95)

References (42)
  • 1
    • 0037812658 scopus 로고    scopus 로고
    • The influence of finasteride on the development of prostate cancer
    • Thompson IM, Goodman PJ, Tangen CM, et al. The influence of finasteride on the development of prostate cancer. N Engl J Med 2003; 349:215-224. This landmark paper describes the findings of the first large-scale US National Cancer Institute-funded prostate cancer prevention effort in the United States. The results demonstrate the willingness and ability of men at risk for prostate cancer to enrol in and complete a 7-year study and obtain meaningful results.
    • (2003) N Engl J Med , vol.349 , pp. 215-224
    • Thompson, I.M.1    Goodman, P.J.2    Tangen, C.M.3
  • 2
    • 0038678851 scopus 로고    scopus 로고
    • The prevention of prostate cancer: The dilemma continues
    • Scardino PT. The prevention of prostate cancer: the dilemma continues. N Engl J Med 2003; 349:297-299. This editorial accompanying the publication of the PCPT urges caution in its interpretation.
    • (2003) N Engl J Med , vol.349 , pp. 297-299
    • Scardino, P.T.1
  • 3
    • 0346905442 scopus 로고    scopus 로고
    • Prevention of prostate cancer with finasteride: A U.S./European perspective
    • Thompson I, Klein EA, Lippman SM. Prevention of prostate cancer with finasteride: A U.S./European perspective. Eur Urol 2003; 44:650-655.
    • (2003) Eur Urol , vol.44 , pp. 650-655
    • Thompson, I.1    Klein, E.A.2    Lippman, S.M.3
  • 4
    • 0347129606 scopus 로고    scopus 로고
    • Selenium: Epidemiology and basic science
    • Klein EA. Selenium: epidemiology and basic science. J Urol 2004; 171 (2 Pt 2): S50-53
    • (2004) J Urol , vol.171 , Issue.2 PART 2
    • Klein, E.A.1
  • 5
    • 0037455838 scopus 로고    scopus 로고
    • Serum Se and risk of prostate cancer in U.S. blacks and whites
    • Vogt TM, Ziegler RG, Graubard BI, et al. Serum Se and risk of prostate cancer in U.S. blacks and whites. Int J Cancer 2003; 103:664-670.
    • (2003) Int J Cancer , vol.103 , pp. 664-670
    • Vogt, T.M.1    Ziegler, R.G.2    Graubard, B.I.3
  • 6
    • 0038244793 scopus 로고    scopus 로고
    • Se supplementation, baseline plasma Se status, and incidence of prostate cancer: An analysis of the complete treatment period of the Nutritional Prevention of Cancer study group
    • Duffield-Lillico AJ, Dalkin BL, Reid ME, et al. Se supplementation, baseline plasma Se status, and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer study group. BJU Int 2003; 91:608-612. This is a follow-up report of the initial randomized, blinded, placebo-controled trial comparing the effects of 200 μg yeast with placebo on the effect of non-melanoma skin cancer recurrence.
    • (2003) BJU Int , vol.91 , pp. 608-612
    • Duffield-Lillico, A.J.1    Dalkin, B.L.2    Reid, M.E.3
  • 7
    • 0141675027 scopus 로고    scopus 로고
    • Toenail selenium levels and the subsequent risk of prostate cancer: A prospective cohort study
    • van den Brandt PA, Zeegers MP, Bode P, Goldbohm RA. Toenail selenium levels and the subsequent risk of prostate cancer: a prospective cohort study. Cancer Epidemiol Biomarkers Prev 2003; 12:866-871. This describes an illustrative epidemiologic study on the risk reduction associated with high levels of selenium.
    • (2003) Cancer Epidemiol Biomarkers Prev , vol.12 , pp. 866-871
    • Van Den Brandt, P.A.1    Zeegers, M.P.2    Bode, P.3    Goldbohm, R.A.4
  • 9
    • 0037224465 scopus 로고    scopus 로고
    • Delineation of the molecular basis for Se-induced growth arrest in human prostate cancer cells by oligonucleotide array
    • Dong Y, Zhang H, Hawthorne L, et al. Delineation of the molecular basis for Se-induced growth arrest in human prostate cancer cells by oligonucleotide array. Cancer Res 2003; 63:52-59. This article builds on previous work demonstrating that selenium acts early in carcinogenesis to prevent clonal expansion of nascent tumors by blocking cell proliferation and promoting cell death, and that its effects are mediated by a variety of well-defined molecular pathways.
    • (2003) Cancer Res , vol.63 , pp. 52-59
    • Dong, Y.1    Zhang, H.2    Hawthorne, L.3
  • 10
    • 0742288062 scopus 로고    scopus 로고
    • Diverse effects of methylseleninic acid on the transcriptional program of human prostate cancer cells
    • Zhao H, Whitfield ML, Xu T, et al. Diverse effects of methylseleninic acid on the transcriptional program of human prostate cancer cells. Mol Biol Cell 2004; 15:506-519. This study confirmed previous observations on the effect of selenium on cell cycling, and demonstrated for the first time that selenium acts as an antiandrogen and induces antioxidant enzymes. The results suggest that the protective effect of selenium are mediated by several different pathways.
    • (2004) Mol Biol Cell , vol.15 , pp. 506-519
    • Zhao, H.1    Whitfield, M.L.2    Xu, T.3
  • 11
    • 0142219868 scopus 로고    scopus 로고
    • Synergy between selenium and vitamin E in apoptosis induction is associated with activation of distinctive initiator caapases in human prostate cancer cells
    • Zu K, Ip C. Synergy between selenium and vitamin E in apoptosis induction is associated with activation of distinctive initiator caapases in human prostate cancer cells. Cancer Res 2003; 63:6988-6995. This study demonstrated synergy of vitamin E and selenium against cell proliferation in prostate cancer cell lines, primarily by augmentation of apoptosis.
    • (2003) Cancer Res , vol.63 , pp. 6988-6995
    • Zu, K.1    Ip, C.2
  • 12
    • 0037420025 scopus 로고    scopus 로고
    • Effects of dietary Se supplementation on DNA damage and apoptosis in canine prostate
    • Waters DJ, Shen S, Cooley DM, et al. Effects of dietary Se supplementation on DNA damage and apoptosis in canine prostate. J Natl Cancer Inst 2003; 95:237-241. This placebo-controlled trial demonstrated that important antioxidant effects of oral selenium are measurable in the prostate in an in-vivo canine model, serving as an important proof-of-principle study for the use of selenium in prevention of prostate cancer.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 237-241
    • Waters, D.J.1    Shen, S.2    Cooley, D.M.3
  • 13
    • 0042737951 scopus 로고    scopus 로고
    • Prostatic and peripheral blood selenium levels after oral supplementation
    • Gianduzzo TR, Holmes EG, Tinggi U, et al. Prostatic and peripheral blood selenium levels after oral supplementation. J Urol 2003; 170:870-873. This study demonstrated that oral selenium is concentrated in the prostate.
    • (2003) J Urol , vol.170 , pp. 870-873
    • Gianduzzo, T.R.1    Holmes, E.G.2    Tinggi, U.3
  • 14
    • 0037369117 scopus 로고    scopus 로고
    • Selonomethionine does not affect PSA secretion independent of its effect on LNCap growth
    • Bhamre S, Whitin JC, Cohen HJ. Selonomethionine does not affect PSA secretion independent of its effect on LNCap growth. Prostate 2003; 54:315-321. This describes an important observation that selenium does not affect PSA secretion, suggesting that selenium use in human trials will not require adjustment of PSA values in deciding on the need for prostate biopsy (unlike what was required for finasteride in the PCPT).
    • (2003) Prostate , vol.54 , pp. 315-321
    • Bhamre, S.1    Whitin, J.C.2    Cohen, H.J.3
  • 15
    • 0142124893 scopus 로고    scopus 로고
    • Selenium and prevention of prostate cancer in high-risk men: The Negative Biopsy Study
    • Stratton MS, Reid ME, Schwartzberg G, et al. Selenium and prevention of prostate cancer in high-risk men: the Negative Biopsy Study. Anticancer Drugs 2003; 14:589-594.
    • (2003) Anticancer Drugs , vol.14 , pp. 589-594
    • Stratton, M.S.1    Reid, M.E.2    Schwartzberg, G.3
  • 16
    • 0142061650 scopus 로고    scopus 로고
    • Selenium and inhibition of disease progression in men diagnosed with prostate carcinoma: Study design and baseline characteristics of the 'Watchful Waiting' Study
    • Stratton MS, Reid ME, Schwartzberg G, et al. Selenium and inhibition of disease progression in men diagnosed with prostate carcinoma: study design and baseline characteristics of the 'Watchful Waiting' Study. Anticancer Drugs 2003; 14:595-600.
    • (2003) Anticancer Drugs , vol.14 , pp. 595-600
    • Stratton, M.S.1    Reid, M.E.2    Schwartzberg, G.3
  • 17
    • 0037427539 scopus 로고    scopus 로고
    • Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery
    • Ni J, Chen M, Zhang Y, et al. Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery. Biochem Biophys Res Commun 2003; 300:357-363. This study demonstrated the effects of vitamin E succinate on cell cycle arrest in prostate cancer cell lines, identified which molecular pathways are modulated, and suggested synergism with selenium in inhibiting cellular proliferation.
    • (2003) Biochem Biophys Res Commun , vol.300 , pp. 357-363
    • Ni, J.1    Chen, M.2    Zhang, Y.3
  • 18
    • 2342573753 scopus 로고    scopus 로고
    • Androgen antagonist activity by the antioxidant moiety of vitamin E, 2,2,5,7,8-pentamethyl-6-chromanol, in human prostate carcinoma cells
    • Thompson TA, Wilding G. Androgen antagonist activity by the antioxidant moiety of vitamin E, 2,2,5,7,8-pentamethyl-6-chromanol, in human prostate carcinoma cells. Mol Cancer Ther 2003; 2:797-803. This study demonstrated a potent antiandrogen effect for vitamin E, adding to the list of potential mechanisms by which vitamin E inhibits prostate cancer.
    • (2003) Mol Cancer Ther , vol.2 , pp. 797-803
    • Thompson, T.A.1    Wilding, G.2
  • 19
    • 0038116394 scopus 로고    scopus 로고
    • ATBC Study Group: Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: A postintervention follow-up
    • Virtamo J, Pietinen P, Huttunen JK, et al. ATBC Study Group: Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: a postintervention follow-up. JAMA 2003; 290:476-485. This study reported long-term post-intervention effects of β-carotene and α-tocopherol on cancer incidence, cause-specific mortality, and overall mortality in men on the ATBC trial.
    • (2003) JAMA , vol.290 , pp. 476-485
    • Virtamo, J.1    Pietinen, P.2    Huttunen, J.K.3
  • 20
    • 0037782104 scopus 로고    scopus 로고
    • The association between lung and prostate cancer risk, and serum micronutrients: Results and lessons learned from beta-carotene and retinol efficacy trial
    • Goodman GE, Schaffer S, Omenn GS, et al. The association between lung and prostate cancer risk, and serum micronutrients: results and lessons learned from beta-carotene and retinol efficacy trial. Cancer Epidemiol Biomarkers Prev 2003; 12:518-526. This study suggested that both the beneficial and deleterious effects of oral supplements disappear after they are no longer ingested, raising interesting questions on the molecular mechanisms underlying their effects and the best way to provide beneficial supplements to the population at large.
    • (2003) Cancer Epidemiol Biomarkers Prev , vol.12 , pp. 518-526
    • Goodman, G.E.1    Schaffer, S.2    Omenn, G.S.3
  • 21
    • 0037442025 scopus 로고    scopus 로고
    • Prospective study of antioxidant micronutrients in the blood and the risk of developing prostate cancer
    • Huang HY, Alberg AJ, Norkus EP, et al. Prospective study of antioxidant micronutrients in the blood and the risk of developing prostate cancer. Am J Epidemiol 2003; 157:335-344. This describes one of several studies causing controversy over whether γ-tocopherol is more active in preventing prostate cancer than α-tocopherol. This finding has not been replicated in the ATBC trial or in several other studies.
    • (2003) Am J Epidemiol , vol.157 , pp. 335-344
    • Huang, H.Y.1    Alberg, A.J.2    Norkus, E.P.3
  • 22
    • 0141958547 scopus 로고    scopus 로고
    • The Selenium and Vitamin E Cancer Prevention Trial
    • Klein EA, Thompson IM, Lippman SM, et al. The Selenium and Vitamin E Cancer Prevention Trial. World J Urol 2003; 21:21-27. This article is an overview of the epidemiologic and biologic data supporting the use of selenium and vitamin E as preventative agents and the design assumptions of the Selenium and Vitamin E Cancer Prevention Trial.
    • (2003) World J Urol , vol.21 , pp. 21-27
    • Klein, E.A.1    Thompson, I.M.2    Lippman, S.M.3
  • 23
    • 0038676422 scopus 로고    scopus 로고
    • Pathways modeling the growth-inhibitory actions of vitamin D in prostate cancer
    • Peehl DM, Krishnan AV, Feldman D. Pathways modeling the growth-inhibitory actions of vitamin D in prostate cancer. J Nutr 2003; 133 (Suppl 7):2461S-2469S. These authors provide a nice summary of the epidemiologic data supporting the hypothesis that vitamin D deficiency is associated with prostate cancer risk, as well as an overview of molecular mechanisms potentialy underlying its action.
    • (2003) J Nutr , vol.133 , Issue.7 SUPPL.
    • Peehl, D.M.1    Krishnan, A.V.2    Feldman, D.3
  • 24
    • 0038054836 scopus 로고    scopus 로고
    • Susceptibility to prostate cancer: Studies on interactions between UVR exposure and skin type
    • Bodiwala D, Luscombe CJ, French ME, et al. Susceptibility to prostate cancer: studies on interactions between UVR exposure and skin type. Carcinogenesis 2003; 24:711-717.
    • (2003) Carcinogenesis , vol.24 , pp. 711-717
    • Bodiwala, D.1    Luscombe, C.J.2    French, M.E.3
  • 25
    • 0041846629 scopus 로고    scopus 로고
    • Calcium, dairy products, and risk of prostate cancer in a prospective cohort of United States men
    • Rodriguez C, McCullough ML, Mondul AM, et al. Calcium, dairy products, and risk of prostate cancer in a prospective cohort of United States men. Cancer Epidemiol Biomarkers Prev 2003; 12:597-603. This was a well-designed prospective study examining dietary dairy and calcium intake and the risk of prostate cancer.
    • (2003) Cancer Epidemiol Biomarkers Prev , vol.12 , pp. 597-603
    • Rodriguez, C.1    McCullough, M.L.2    Mondul, A.M.3
  • 26
    • 8844273350 scopus 로고    scopus 로고
    • Inhibition of prostate cancer growth by vitamin D: Regulation of target gene expression
    • Krishnan AV, Peehl DM, Feldman D. Inhibition of prostate cancer growth by vitamin D: Regulation of target gene expression. J Cell Biochem 2003; 68:363-371. This is an excelent overview of the molecular targets of vitamin D in prostate cancer, highlighting the role of insulin-like growth factor binding protein 1.
    • (2003) J Cell Biochem , vol.68 , pp. 363-371
    • Krishnan, A.V.1    Peehl, D.M.2    Feldman, D.3
  • 27
    • 0038625360 scopus 로고    scopus 로고
    • Cyclooxygenase-2 as a potential target in the prevention and treatment of genitourinary tumors: A review
    • Pruthi RS, Derksen E, Gaston K. Cyclooxygenase-2 as a potential target in the prevention and treatment of genitourinary tumors: a review. J Urol 2003; 169:2352-2359. This is an excellent overview of the pathogenesis of COX-2 in urological cancers and the rationale for COX-2 inhibitors in prevention and therapy.
    • (2003) J Urol , vol.169 , pp. 2352-2359
    • Pruthi, R.S.1    Derksen, E.2    Gaston, K.3
  • 28
    • 0345505237 scopus 로고    scopus 로고
    • Cyclooxygenase-2 and prostate carcinogenesis
    • Hussain T, Gupta S, Mukhtar H. Cyclooxygenase-2 and prostate carcinogenesis. Cancer Lett 2003; 191:125-135.
    • (2003) Cancer Lett , vol.191 , pp. 125-135
    • Hussain, T.1    Gupta, S.2    Mukhtar, H.3
  • 29
    • 0042026388 scopus 로고    scopus 로고
    • The cyclooxygenase 2-specific nonsteroidal anti-inflammatory drugs celecoxib and nimesulide inhibit androgen receptor activity via induction of c-Jun in prostate cancer cells
    • Pan Y, Zhang JS, Gazi MH, Young CY. The cyclooxygenase 2-specific nonsteroidal anti-inflammatory drugs celecoxib and nimesulide inhibit androgen receptor activity via induction of c-Jun in prostate cancer cells. Cancer Epidemiol Biomarkers Prev 2003; 12:769-774. This describes the first observation that COX-2 inhibitors have direct antiandrogenic effects.
    • (2003) Cancer Epidemiol Biomarkers Prev , vol.12 , pp. 769-774
    • Pan, Y.1    Zhang, J.S.2    Gazi, M.H.3    Young, C.Y.4
  • 30
    • 0037699032 scopus 로고    scopus 로고
    • Bevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma
    • Shappell SB, Olson SJ, Hannah SE, et al. Bevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma. Cancer Res 2003; 63:2256-2267. This interesting study suggested selective expression of COX-2 in precursor lesions of prostate cancer, establishing an excellent model system for studying COX-2 inhibition as a preventative strategy.
    • (2003) Cancer Res , vol.63 , pp. 2256-2267
    • Shappell, S.B.1    Olson, S.J.2    Hannah, S.E.3
  • 31
    • 0041846598 scopus 로고    scopus 로고
    • Soy and isoflavone consumption in relation to prostate cancer risk in China
    • Lee MM, Gomez SL, Chang JS, et al. Soy and isoflavone consumption in relation to prostate cancer risk in China. Cancer Epidemiol Biomarkers Prev 2003; 12:665-668. This well-done study demonstrated the protective effect of diets high in soy on the risk of prostate cancer even in a low-risk country like China. This study raises interesting questions about dietary and environmental interactions.
    • (2003) Cancer Epidemiol Biomarkers Prev , vol.12 , pp. 665-668
    • Lee, M.M.1    Gomez, S.L.2    Chang, J.S.3
  • 32
    • 0037223129 scopus 로고    scopus 로고
    • Soy isoflavonoid equal modulates the growth of benign and malignant prostate epithelial cells in vitro
    • Hedlund TE, Johannes WU, Miller GJ. Soy isoflavonoid equal modulates the growth of benign and malignant prostate epithelial cells in vitro. Prostate 2003; 54:68-78.
    • (2003) Prostate , vol.54 , pp. 68-78
    • Hedlund, T.E.1    Johannes, W.U.2    Miller, G.J.3
  • 33
    • 0037441382 scopus 로고    scopus 로고
    • Effect of soy protein isolate and conjugated linoleic acid on the growth of Dunning R-3327-AT-1 rat prostate tumors
    • Cohen LA, Zhao Z, Pittman B, Scimeca J. Effect of soy protein isolate and conjugated linoleic acid on the growth of Dunning R-3327-AT-1 rat prostate tumors. Prostate 2003; 54:169-180.
    • (2003) Prostate , vol.54 , pp. 169-180
    • Cohen, L.A.1    Zhao, Z.2    Pittman, B.3    Scimeca, J.4
  • 34
    • 0037312591 scopus 로고    scopus 로고
    • Genistein and daidzein downregulate prostate androgen-regulated transcript-1 (PART-1) gene expression induced by dihydrotestosterone in human prostate LNCaP cancer cells
    • Yu L, Blackburn GL, Zhou JR. Genistein and daidzein downregulate prostate androgen-regulated transcript-1 (PART-1) gene expression induced by dihydrotestosterone in human prostate LNCaP cancer cells. J Nutr 2003; 133:389-392. This study demonstrated a potential antiandrogenic effect for the major isoflavones found in soy.
    • (2003) J Nutr , vol.133 , pp. 389-392
    • Yu, L.1    Blackburn, G.L.2    Zhou, J.R.3
  • 35
    • 0038606063 scopus 로고    scopus 로고
    • Tomato and soy polyphenols reduce insulin-like growth factor-1-stimulated rat prostate cancer cell proliferation and apoptotic resistance in vitro via inhibition of intracellular signaling pathways involving tyrosine kinase
    • Wang S, DeGroff VL, Clinton SK. Tomato and soy polyphenols reduce insulin-like growth factor-1-stimulated rat prostate cancer cell proliferation and apoptotic resistance in vitro via inhibition of intracellular signaling pathways involving tyrosine kinase. J Nutr 2003; 133:2367-2376. Insulin-like growth factor I is a known risk factor for prosate cancer in humans, and this article suggests that the polyphenols in soy and tomato products may be effective in inhibiting its action.
    • (2003) J Nutr , vol.133 , pp. 2367-2376
    • Wang, S.1    DeGroff, V.L.2    Clinton, S.K.3
  • 36
    • 0042261670 scopus 로고    scopus 로고
    • Inhibition of the proteasome activity, a novel mechanism associated with the tumor cell apoptosis-inducing ability of genistein
    • Kazi A, Daniel KG, Smith DM, et al. Inhibition of the proteasome activity, a novel mechanism associated with the tumor cell apoptosis-inducing ability of genistein. Biochem Pharmacol 2003; 66:965-976.
    • (2003) Biochem Pharmacol , vol.66 , pp. 965-976
    • Kazi, A.1    Daniel, K.G.2    Smith, D.M.3
  • 37
    • 0037307213 scopus 로고    scopus 로고
    • Soy consumption and phytoestrogens: Effect on serum prostate specific antigen when blood lipids and oxidized low-density lipoprotein are reduced in hyperlipidemic men
    • Jenkins DJ, Kendall CW, D'Costa MA, et al. Soy consumption and phytoestrogens: effect on serum prostate specific antigen when blood lipids and oxidized low-density lipoprotein are reduced in hyperlipidemic men. J Urol 2003; 169:507-511. This was one of the few studies to look at the effect of soy on serum PSA levels, which surprisingly did not change despite the known estrogenic effects of these compounds.
    • (2003) J Urol , vol.169 , pp. 507-511
    • Jenkins, D.J.1    Kendall, C.W.2    D'Costa, M.A.3
  • 38
    • 0242410142 scopus 로고    scopus 로고
    • Lycopene inhibits the growth of normal human prostate epithelial cells in vitro
    • Obermuller-Jevic UC, Olano-Martin E, et al. Lycopene inhibits the growth of normal human prostate epithelial cells in vitro. J Nutr 2003; 133:3356-3360.
    • (2003) J Nutr , vol.133 , pp. 3356-3360
    • Obermuller-Jevic, U.C.1    Olano-Martin, E.2
  • 39
    • 0037574103 scopus 로고    scopus 로고
    • Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone- treated rats fed tomato powder, lycopene, or energy-restricted diets
    • Boilesu TW, Liao Z, Kim S, et al. Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets. J Natl Cancer Inst 2003; 95:1578-1586. This study illustrated the effect of caloric restriction and dietary supplementation on risk of dying from prostate cancer in a mice model, and highlights differential effects of whole foods versus individual dietary supplements.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 1578-1586
    • Boilesu, T.W.1    Liao, Z.2    Kim, S.3
  • 40
    • 0038000122 scopus 로고    scopus 로고
    • Molecular targets for green tea in prostate cancer prevention
    • Adhami VM, Ahmad N, Mukhtar H. Molecular targets for green tea in prostate cancer prevention. J Nutr 2003; 133 (Suppl 7):2417S-2424S.
    • (2003) J Nutr , vol.133 , Issue.7 SUPPL.
    • Adhami, V.M.1    Ahmad, N.2    Mukhtar, H.3
  • 41
    • 0043067996 scopus 로고    scopus 로고
    • Role of p63 and NF-kappaB in epigallocatechin-3-gallate-induced apoptosis of LNCaP cells
    • Hastak K, Gupta S, Ahmad N, et al. Role of p63 and NF-kappaB in epigallocatechin-3-gallate-induced apoptosis of LNCaP cells. Oncogene 2003; 22:4851-4859. This is a dissection of the molecular effects of the major polyphenol in green tea.
    • (2003) Oncogene , vol.22 , pp. 4851-4859
    • Hastak, K.1    Gupta, S.2    Ahmad, N.3
  • 42
    • 0041337028 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells
    • Brusselmans K, De Schrijver E, Heyns W, et al. Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells. Int J Cancer 2003; 108:856-862. This article suggests a novel mechanism for the antiapoptotic effect of EGCG, involving fatty acid synthase, a known marker for progression for prostate cancer.
    • (2003) Int J Cancer , vol.108 , pp. 856-862
    • Brusselmans, K.1    De Schrijver, E.2    Heyns, W.3


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