Lack of association between the serotonin transporter promoter gene polymorphism and impulsivity or aggressive behavior among suicide attempters and healthy volunteers

Psychiatry Research

Volumn 126, Issue 2, 2004, Pages 99-106

  Baca Garcia, Enrique ^a   Vaquero, Concepción ^b   Diaz Sastre, Carmen ^c   García Resa, Eloy ^d   Saiz Ruiz, Jeronimo ^d   Fernández Piqueras, José ^b   De Leon, Jose ^e  

^a Fundacion Jimenz Diaz   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^d UNIVERSITY OF ALCALÁ   (Spain)

^e EASTERN STATE HOSPITAL   (United States)

Author keywords

17q11.1 q12; Barratt Impulsiveness Scale; Brown Goodwin Aggressive Behavior Scale; Genetics; Serotonin; Serotonin transporter; Suicide

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; AGGRESSION; ARTICLE; BLOOD DONOR; BORDERLINE STATE; CONTROLLED STUDY; CULTURAL ANTHROPOLOGY; DNA POLYMORPHISM; FEMALE; GENETIC ANALYSIS; GENOTYPE; HUMAN; IMPULSIVENESS; MAJOR CLINICAL STUDY; MALE; PREMOTOR CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RATING SCALE; SEX DIFFERENCE; SPAIN; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; SUICIDAL BEHAVIOR;

ADULT; AGGRESSION; CARRIER PROTEINS; FEMALE; GENOTYPE; HUMANS; IMPULSE CONTROL DISORDERS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); QUESTIONNAIRES; REPRODUCIBILITY OF RESULTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SUICIDE, ATTEMPTED;

EID: 2342591384     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psychres.2003.10.007     Document Type: Article

References (33)

1. Baca-Garcia E., Vaquero C., Diaz-Sastre C., Ceverino A., Saiz-Ruiz J., Fernandez-Piqueras J., de Leon J. A gender-specific association between the serotonin transporter gene and suicide attempts. Neuropsychopharmacology. 26:2002;692-695
2. Bondy B., Erfurth A., de Jonge S., Kruger M., Meyer H. Possible association of the short allele of the serotonin transporter promoter gene polymorphism (5-HTTLPR) with violent suicide. Molecular Psychiatry. 5:2000;193-195
3. Brown C.S., Kent T.A., Bryant S.G., Gevedon R.M., Campbell J.L, Felthous A.R., Barratt E.S., Rose R.M. Blood platelet uptake of serotonin in episodic aggression. Psychiatry Research. 27:1989;5-12
4. Brown G.L., Goodwin F.K., Ballenger J.C., Goyer P.F., Major L.F. Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Research. 1:1979;131-139
5. Cavalli-Sforza L.L., Menozzi P., Piazza A. The History and Geography of Human Genes. 1994;285-287 Princeton University Press, Princenton, NJ
6. Chung Y.O., Lee C.W. A study of factor structures of the Barratt Impulsiveness Scale in Korean university students. Korean Journal of Clinical Psychology. 16:1997;117-129
7. Coccaro E.F. Impulsive aggression and central serotonergic system function in humans: an example of a dimensional brain-behavior relationship. International Clinical Psychopharmacology. 7:1992;3-12
8. Coccaro E.F., Kavoussi R.J., Hauger R.L., Cooper T.B., Ferris C.F. Cerebrospinal fluid vasopressin levels: correlates with aggression and serotonin function in personality-disordered subjects. Archives of General Psychiatry. 55:1998;708-714
9. Coccaro E.F., Kavoussi R.J., Sheline Y.I., Berman M.E., Csernansky J.G. Impulsive aggression in personality disorder correlates with platelet 5-HT2A receptor binding. Neuropsychopharmacology. 16:1997;211-216
10. Coccaro E.F., Kavoussi R.J., Sheline Y.I., Lish J.D., Csernansky J.G. Impulsive aggression in personality disorder correlates with tritiated paroxetine binding in the platelet. Archives of General Psychiatry. 53:1996a;531-536
11. Coccaro E.F., Berman M.E., Kavoussi R.J., Hauger R.L. Relationship of prolactin response to D-fenfluramine to behavioral and questionnaire assessments of aggression in personality disordered men. Biological Psychiatry. 40:1996b;557-564
12. Du L., Faludi G., Palkovits M., Demeter E., Bakish D., Lapierre Y.D., Sotonyi P., Hrdina P.D. Frequency of long allele in serotonin transporter gene is increased in depressed suicide victims. Biological Psychiatry. 46:1999;196-201
13. Fossati A., Ceglie A.D., Acquarini E., Barratt E.S. Psychometric properties of an Italian version of the Barratt Impulsiveness Scale-11 (BIS-11) in non-clinical subjects. Journal of Clinical Psychology. 57:2001;815-828
14. Geijer T., Frisch A., Persson M.L., Wasserman D., Rockah R., Michaelovsky E., Apter A., Jönsson E.G., Nöthen M.M., Weizman A. Search for association between suicide attempt and serotonergic polymorphisms. Psychiatry Genetics. 10:2000;19-26
15. Heils A., Teufel A., Petri S., Stober G., Riederer P., Bengel D., Lesch K.P. Allelic variation of human serotonin transporter gene expression. Journal of Neurochemistry. 66:1996;2621-2624
16. Heinz A., Jones D.W., Mazzanti C., Goldman D., Ragan P., Hommer D., Linnoila M., Weinberger D.R. A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biological Psychiatry. 47:2000;643-649
17. Lesch K.P., Hiels A. Serotonergic gene transcription control regions: targets for antidepressant drug development. International Journal of Neuropsychopharmacology. 3:2000;67-79
18. Linnoila V.L., Virkkunen M. Aggression, suicidality and serotonin. Journal of Clinical Psychiatry. 53:(10 suppl):1992;46-51
19. Lobo A., Pérez-Echevarria M.J., Artal J. Validity of the scaled versión of General Health Questionaire (GHQ-28) in Spanish population. Psychological Medicine. 16:1998;135-140
20. Mann J.J., Waternaux C., Gretcher L.H., Malone K.M. Toward a clinical model of suicidal behavior in psychiatric patients. American Journal of Psychiatry. 156:1999;181-189
21. Manuck S.B., Flory J.D., McCaffery J.M., Matthews K.A., Mann J.J., Muldoon M.F. Aggression, impulsivity, and central nervous system serotonergic responsivity in a non-patient sample. Neuropsychopharmacology. 19:1998;287-299
22. Moeller F.G., Barratt E.S., Dougherty D.M., Schmitz J.M., Swann A.C. Psychiatric aspects of impulsivity. American Journal of Psychiatry. 158:2001;1783-1793
23. Oquendo M.A., Baca-Garcia E., Graver R., Morales M., Montalvan V., Mann J.J. Spanish adaptation of the Barratt Impulsiveness Scale (BIS-11). European Journal of Psychiatry. 15:2001;147-155
24. Patkar A.A., Berrettini W.H., Hoehe M., Thornton C.C., Gottheil E., Hill K., Weinstein S.P. Serotonin transporter polymorphisms and measures of impulsivity, aggression and sensation seeking among African-American cocaine-dependent individuals. Psychiatry Research. 110:2002;103-115
25. Patton J.H., Stanford M.S., Barratt E.S. Factor structure of the Barratt Impulsiveness Scale. Journal of Clinical Psychology. 51:1995;768-774
26. 3H] paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivity. Psychiatry Research. 96:2000;51-61
27. Reist C., Mazzanti C., Vu R., Tran D., Goldman D. Serotonin transporter promoter polymorphism is associated with attenuated prolactin response to fenfluramine. American Journal of Medical Genetics. 105:2001;363-368
28. Seroczynski A.D., Bergeman C.S., Coccaro E.F. Etiology of the impulsivity/aggression relationship: genes or environment? Psychiatry Research. 86:1999;41-57
29. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E., Hergueta T., Baker R., Dunbar G.C. Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry. 59:(Suppl 20):1998;22-33
30. Stanley B., Molcho A., Stanley M., Winchel R., Gameroff M.J., Parsons B., Mann J.J. Association of aggressive behavior with altered serotonergic function in patients who are not suicidal. American Journal of Psychiatry. 157:2000;609-614
31. Williams R.B., Marchuk D.A., Gadde K.M., Barefoot J.C., Grichnik K., Helms M.J., Kuhn C.M., Lewis J.G., Schanberg S.P., Stafford-Smith M., Suarez E.C., Clary G.L., Svenson I.K., Siegler I.C. Central nervous system serotonin function and cardiovascular responses to stress. Psychosomatic Medicine. 63:2001;300-305
32. World Health Organization. International Personality Disorder Examination (IPDE)-ICD-10 Module. 1996;Cambridge University Press, New York
33. Zalsman G., Frisch A., Bromberg M., Gelernter J., Michaelovsky E., Campino A., Erlich Z., Tyano S., Apter A., Weizman A. Family-based association study of serotonin transporter promoter in suicidal adolescents: possible role in violence traits. American Journal of Medical Genetics. 105:2001;239-245