The human red cell voltage-regulated cation channel. The interplay with the chloride conductance, the Ca2+-activated K+ channel and the Ca2+ pump

Journal of Membrane Biology

Volumn 195, Issue 1, 2003, Pages 1-8

  Bennekou, P ^a   Kristensen, B I ^a   Christophersen, P ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NEUROSEARCH A S   (Denmark)

Author keywords

Erythrocyte; G rdos channel; Hysteresis; Non selective cation channel

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ION; POTASSIUM ION; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; CALCIUM TRANSPORT; CHLORIDE CONDUCTANCE; CONTROLLED STUDY; ERYTHROCYTE; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; KINETICS; MEMBRANE POTENTIAL; SUSPENSION;

ADAPTATION, PHYSIOLOGICAL; CALCIUM; CALCIUM-TRANSPORTING ATPASES; CELLS, CULTURED; CHLORIDE CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC CONDUCTIVITY; ERYTHROCYTE MEMBRANE; ERYTHROCYTES; FEEDBACK; HOMEOSTASIS; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; ION CHANNEL GATING; ION CHANNELS; MEMBRANE POTENTIALS; NONLINEAR DYNAMICS; POTASSIUM; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; POTASSIUM CHANNELS, VOLTAGE-GATED;

EID: 0141428833     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-003-2036-6     Document Type: Article

References (27)

1. Adorante, J.S., Macey, R.I. 1986. Calcium-induced transient potassium efflux in human red blood cells. Am. J. Physiol. 250:C55-C64
2. +-valinomycin and chloride conductance of the human red cell membrane. Influence of the membrane protonophore carbonylcyanide m-chlorophenylhydrazone. Biochim. Biophys. Acta 776:1-9
3. Bennekou, P. 1988. Protonophore anion permeability of the human red cell membrane determined in the presence of valinomycin. J. Membrane Biol. 102:225-234
4. Bennekou, P. 1993. The voltage-gated non-selective cation channel from human red cells is sensitive to acetylcholine. Biochim. Biophys. Acta 1147:165-167
5. Bennekou, P. 1999. The feasibility of pharmacological volume control of sickle cells is dependent on the quantization of the transport pathways. A model study. J. Theor. Biol. 196:129-137.
6. Bennekou, P., Christophersen, P. 1992. A human red cell cation channel showing hysteresis like voltage activation/inactivation. Acta Physiol. Scand. 146 Sup: 608:56
7. Bennekou, P., Pedersen, O., Moller, A., Christophersen, P. 2000. Volume control in sickle cells is facilitated by the novel anion conductance inhibitor NS1652. Blood 95:1842-1849
8. Christophersen, P., Bennekou, P. 1991. Evidence for a voltage-gated, non-selective cation channel in the human red cell membrane. Biochim. Biophys. Acta 1065:103-106
9. Dawson, H. 1939. Studies on the permeability of erythrocytes. VI. The effect of reducing the salt concentration in the medium surrounding the cell. Biochem. J. 33:389-401
10. Donlon, A.J., Rothstein, A. 1969. The cation permeability of erythrocytes in low ionic strength media of various tonicities. J. Membrane Biol. 1:37-52
11. --dependent cation conductance in human red blood cells. J. Physiol. 539:847-855
12. Fanger, CM, Ghanshani, S, Logsdon, NJ, Rauer, H, Kalman, K, Zhou, J, Beckingham, K, Chandy, KE, Cahalan, MD, Aiyar, J. 1999. Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCal. J. Biol. Chem. 274:5746-5754
13. Fomenti, A., Rodighiero, S. 2001. Whole-cell and perforated-patch recordings of voltage-dependent outward and inward cation currents in human red blood cells. XIII Meeting of the European Association for Red Cell Research. 72.
14. Freedman, J.C., Hoffman, J.F. 1979. Ionic and osmotic equilibria of human red blood cells treated with nystatin. J. Gen. Physiol. 74:157-185
15. Halperin, J.A., Brugnara, C., Tosteson, M.T., Van Ha, T., Tosteson, D.C. 1989. Voltage-activated cation transport in human erythrocytes. Am. J. Physiol. 257:C986-C996
16. Halperin, J.A., Brugnara, C., van Ha, T., Tosteson, D.C. 1990. Voltage-activated cation permeability in high-potassium but no low-potassium red blood cells. Am. J. Physiol. 258:C1169-C1172
17. Heinz, A, Passow, H. 1980. Role of external potassium in the calcium-induced potassium efflux from human red blood cell ghosts. J. Membr. Biol. 57(2):119-131
18. Hodgkin, A.L., Huxley, A.F. 1952. The components of membrane conductance in the giant axon of Loligo. J. Physiol. 116:449-472
19. Huber, S.M., Gamper, N., Lang, F. 2001. Chloride conductance and volume-regulatory nonselective cation conductance in human red blood cell ghosts. Pfluegers Arch. - Eur. J. Physiol. 441:551-558
20. Jones, G.S., Knauf, P.A. 1985. Mechanism of the increase in cation permeability of human erythrocytes in low-chloride media. J. Gen. Physiol. 86:721-738
21. Kaestner, L., Christophersen, P., Bernhardt, I., Bennekou, P. 2001. The non-selective voltage-activated cation channel in the human red blood cell membrane: Reconciliation between two conflicting reports and further characterization. Biolectrichemistry 52:117-125
22. + exchange under low ionic strength conditions. J. Membrane Biol. 176:207-216
23. LaCelle, P.L., Rothstein, A. 1966. The passive permeability of the red blood cell to cations. J. Gen. Physiol. 50:171-189
24. Richter, S., Hamann, J., Kummerow, D., Bernhardt, I. 1997. The monovalent cation 'leak' transport in human erythrocytes: An electroneutral exchange process. Biophys. J. 73:733-745
25. Scharff, O. 1981. Calmodulin and its role in cellular activation. Cell Calcium 2:1-27
26. 2+-ATPase in erythrocyte membranes. Biochem. Biophys. Acta 691:133-143
27. + conductance and membrane potential of human erythrocytes mediated by the ionophore A23187. Biochim. Biophys. Acta 688:37-44