Bretylium, an organic quaternary amine, inhibits the Na,K-ATPase by binding to the extracellular K-site

Blood Cells, Molecules, and Diseases

Volumn 32, Issue 3, 2004, Pages 394-400

  Helms, Jeff B ^a   Arnett, Krista L ^b   Gatto, Craig ^a   Milanick, Mark A ^b,c  

^a ILLINOIS STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

Author keywords

Antiarrhythmic drugs; Competitive inhibition; Enzyme kinetics; P type ATPase

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BRETYLIUM; OUABAIN; POTASSIUM;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG COMPETITION; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ERYTHROCYTE; EXTRACELLULAR FLUID; HUMAN; HUMAN CELL; IC 50; MALE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN HYDROLYSIS; SERUM GROUP KM SYSTEM;

ANTI-ARRHYTHMIA AGENTS; BINDING SITES; BINDING, COMPETITIVE; BRETYLIUM COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; HUMANS; KINETICS; NA(+)-K(+)-EXCHANGING ATPASE; PHOSPHORYLATION; POTASSIUM; PROTEIN CONFORMATION; QUATERNARY AMMONIUM COMPOUNDS; RUBIDIUM;

STROPHANTHUS GRATUS;

EID: 2342588818     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2004.01.013     Document Type: Article

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