Immunoglobulin deficiency in kidney allograft recipients: Comparative effects of mycophenolate mofetil and azathioprine

Transplant Infectious Disease

Volumn 5, Issue 4, 2003, Pages 181-186

  Keven, Kenan ^a,b   Sahin, M ^a   Kutlay, S ^a   Sengul, S ^a   Erturk, S ^a   Ersoz, S ^a   Erbay, B ^a  

^a ANKARA UNIVERSITY   (Turkey)

^b NONE   (United States)

Author keywords

Azathioprine; Immunoglobulin deficiency; Kidney transplantation; Mycophenolate mofetil

Indexed keywords

AZATHIOPRINE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; DRUG DERIVATIVE; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID;

ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; GRAFT REJECTION; HUMAN; HYPOGAMMAGLOBULINEMIA; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN DEFICIENCY; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; INFECTION COMPLICATION; KIDNEY ALLOGRAFT; KIDNEY TRANSPLANTATION; PRIORITY JOURNAL; RECIPIENT; RECURRENT DISEASE; URINARY TRACT INFECTION; ADULT; ALLOTRANSPLANTATION; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; FEMALE; IMMUNOGLOBULIN G DEFICIENCY; MALE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL;

ADULT; AZATHIOPRINE; FEMALE; HUMANS; IGG DEFICIENCY; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; MYCOPHENOLIC ACID; PROSPECTIVE STUDIES; TRANSPLANTATION, HOMOLOGOUS; URINARY TRACT INFECTIONS;

EID: 2342570870     PISSN: 13982273     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3062.2003.00035.x     Document Type: Article

References (17)

1. MASSY ZA, GUIJARRO C, WIEDERKEHR MR, MA JZ, KASISKE BL. Chronic renal allograft rejection: immunologic and nonimmunologic risk factors. Kidney Int 1996: 49: 518-524.
2. VASQUEZ EM, SIFONTIS NM, POLLAK R, BENEDETTI E. Impact of mycophenolate mofetil on recurrent rejection in kidney transplant patients. Clin Transplant 2001: 15: 253-257.
3. Mycofenolate mofetil for the treatment of a first acute renal allograft rejection: three-year follow-up. The Mycophenolate Mofetil Acute Renal Rejection Study Group. Transplantation 2001: 71: 1091-1097.
4. SMITH KG, ISBEL NM, CATTON MG, LEYDON JA, BECKER GJ, WALKER RG. Suppression of the humoral immune response by mycophenolate mofetil. Nephrol Dial Transplant 1998: 13: 160-164.
5. GANSCHOW R, LYONS M, KEMPER MJ, BURDELSKI M. B-cell dysfunction and depletion using mycophenolate mofetil in a pediatric combined liver and kidney graft recipient. Pediatr Transplant 2001: 5: 60-63.
6. BERNABEU-WITTEL M, NARANJO M, CISNEROS JM, et al. Infections in renal transplant recipients receiving mycophenolate versus azathioprine-based immunosuppression. Eur J Clin Microbiol Infect Dis 2002: 21: 173-180.
7. JOHNSON DW, NICOL DL, PURDIE DM, et al. Is mycophenolate mofetil less safe than azathioprine in elderly renal transplant recipients? Transplantation 2002: 73: 1158-1163.
8. HUSAIN S, SINGH N. The impact of novel immunosuppressive agents on infections in organ transplant recipients and the interactions of these agents with antimicrobials. Clin Infect Dis 2002: 35: 53-61.
9. POLLOCK CA, MAHONY JF, IBELS LS, et al. Immunoglobulin abnormalities in renal transplant recipients. Transplantation 1989: 47: 952-956.
10. LEVY J, BARNETT EM MACDONALD NS, KLINENBERG JR, PEARSON CM. The effect of azathioprine on gammaglobulin synthesis in man. J Clin Invest 1972: 51: 2233-2238.
11. CORALES R, CHUA J, MAWHORTER S, et al. Significant post-transplant hypogammaglobulinemia in six heart transplant recipients: an emerging clinical phenomenon? Transplant Infectious Dis 2000: 3: 133-139.
12. YAMANI MH, AVERY RK, MAWHORTER SD, et al. Hypogammaglobulinemia following cardiac transplantation: a link between rejection and infection. J Heart Lung Transplant 2001: 4: 425-430.
13. ALLISON AC, EUGUI EM. Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF). Clin Transplant 1996: 10: 77-84.
14. ROSE ML, SMITH J, DUREAU G, KEOGH A, KOBASHIGOWA J. Mycophenolate mofetil decreases antibody production after cardiac transplantation. J Heart Lung Transplant 2002: 21: 282-285.
15. GHASEMIAN SM, GULERIA AS, KHAWAND NY, LIGHT JA. Diagnosis and management of the urologie complications of renal transplantation. Clin Transplant 1996: 10: 218-223.
16. RUBIN RH. Infectious disease complications of renal transplantation. Kidney Int 1993: 44: 221-236.
17. MULLER V, BECKER G, DELFS M, et al. Do urinary tract infections trigger chronic kidney transplant rejection in man? J Urol 1998: 159: 1826.