Chronic Inhalation Toxicity and Carcinogenicity Study on Potassium Octatitanate Fibers (TISMO) in Rats

Inhalation Toxicology

Volumn 16, Issue 5, 2004, Pages 291-310

  Ikegami, T ^a   Tanaka, A K ^a   Taniguchi, M ^a   Clark, M L ^b   Ragan, H A ^b   Mast, T J ^b   Lee, K P ^c   Ichikawa, Y ^a  

^a OTSUKA CHEMICAL CO LTD   (Japan)

^b BATTELLE MEMORIAL INSTITUTE   (United States)

^c Otsuka Chemical Co Ltd ^*

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM OCTATITANATE FIBER; TITANIUM DERIVATIVE; UNCLASSIFIED DRUG;

AIR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CHRONIC TOXICITY; CONTROLLED STUDY; EXPOSURE; FIBER; HEALTH HAZARD; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; LUNG ALVEOLUS WALL; LUNG BURDEN; LUNG CLEARANCE; LUNG FIBROSIS; MALE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; WORLD HEALTH ORGANIZATION;

ADMINISTRATION, INHALATION; ANIMALS; BODY BURDEN; CARCINOGENICITY TESTS; CARCINOGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; LUNG; MACROPHAGES, ALVEOLAR; MALE; MINERAL FIBERS; MINERALS; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PULMONARY ALVEOLI; RATS; RATS, INBRED F344; TITANIUM;

ANIMALIA;

EID: 2342525887     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/08958370490428391     Document Type: Article

References (43)

1. Abraham, J. L., Churg, A., Green, F. H. Y., Kleinerman, J., Pratt, P. C., Seemayer, T. A., Vallythan, V., and Weil, H. 1982. The pathology of asbestos-associated disease of the lung and pleural cavities: Diagnostic criteria and proposed grading system. Report of the Pneumoconiosis Committee of the College of American Pathologists and the National Institute for Occupational Safety and Health. Arch. Pathol. 106:592-594.
2. Adamson, I. Y. R., and Bowden, D. H. 1974. The Type II cell as progenitor of alveolar epithelial regeneration: A cytodynamic study in mice after exposure to oxygen. Lab. Invest. 30:35-42.
3. American Conferences of Governmental Industrial Hygienists. 1994. Threshold limit values and biological exposure indices for 1993-1994, p. 6. Cincinnatti, OH: ACGIH.
4. Bakerville, A., Thomas, G., Wood, M., and Harris, W. J. 1974. Histology and ultrastructure of metaplasia of alveolar epithelium following infection of mice and hamsters with influenza virus. Br. J. Expl. Pathol. 55:130-137.
5. Bellmann, B., Muhle, H., Creutzenberg, O., Ernst, H., Brown, R. C., and S'ebastien, P. 2001. Effects of nonfibrous particles on ceramic fiber (RCF1) toxicity in rats. Inhal. Toxicol. 13:877-901.
6. Bignon, J., Brochard, P., Brown, R., Davis, J. M. G., Vu, V., Gibb, B., Greim, M., Oberdorster, G., and Sebastien, P. 1995. Assessment of the toxicity of man-made fibers. A final report of a workshop held in Paris, France, 3-4 February 1994. Ann. Occup. Hyg. 39:89-106.
7. Brightwell, J., Fouillet, X. L. M., and Cassanozoppi, A. L. 1985. Some pathological changes observed in rodents following long-term inhalation exposure to high concentrations of automobile exhaust emissions. Proc. American Association for Aerosol Research, Albuquerque, NM, p. 190.
8. Davis, J. M. G., and Jones, A. D. 1988. Comparison of the pathogenicity of long and short fibers of chrysotile asbestos in rats. Br. J. Exp. Pathol. 69:717-737.
9. Drozdowicz, B. Z., Ulrich, C. E., Booth, A. D., Proctor, J. E., and Goldberg, L. 1986. Chronic inhalation study and carcinogenicity study of SRC-I (solvent refined coal) solid in rats. Results from the 6- and 12-month interim sacrifices. Toxicologist 6:532. Abstr., 25th Anniversary meeting.
10. Ellouk, S. A., and Jaurand, M.-C. 1994. Review of animal/in vitro data on biological effects of man-made fibers. Environ. Health, Perspect. 102(suppl. 2):47-63.
11. Fukuda, Y., Ferrans, V. J., Schoenberger, C. L., Rennard, S. I., and Crystal, R. C. 1985. Patterns of pulmonary structural remodeling after experimental paraquat toxicity. Am. J. Pathol. 118:452-475.
12. Heinrich, U., Mulhle, H., Takenaka, S., Ernst, H., Furst, R., Mohr, U., Pott, F., and Stober, W. 1986. Chronic effects on the respiratory tract of hamsters, mice, and rats after long-term of high concentrations of filtered and unfiltered diesel engine emissions. J. Appl. Toxiocol. 6:383-395.
13. Hesterberg, T. W., and Hart, G. A. 2001. Synthetic vitreous fibers: A review of toxicology research and its impact of hazard classification. Crit. Rev. Toxicol. 31(1):1-53.
14. Hesterberg, T. W., Miiller, W. C., Thevenaz, P., and Anderson, R. 1995. Chronic inhalation studies of man-made vitreous fibers: Characterization of fibers in the exposure aerosol and lungs. Ann. Occup. Hyg. 39:637-653.
15. Ikegami, T., Taniguchi, M., Singer, A. W., Brooker, M. J., Yarrington, J., Placke, M. E., and Lee, K. P. 2000. Inhalation toxicity study of potassium octatitanate fibers (TISMO) in rats following 13 weeks of aerosol exposure. Inhal. Toxicol. 12:415-438.
16. Kamstrup, O., Ellehauge, A., Chevalier, J., Davis, J. M. G., McConnell, E. E., and Thevenaz, R. 2001. Chronic inhalation studies of two types of stone wool fibers in rats. Inhal. Toxicol. 13:603-621.
17. Klonne, D., Bruns, J., Halder, C., Holdsworth, C., and Ulrich, C. 1985. Two-year inhalation study of petroleum coke (delayed process) in rats and monkeys. Toxicologist 1:180.
18. Lee, K. P. 1985. Lung response to particulates with emphasis on asbestos and other fibrous dusts. CRC Critical Rev. Toxicol. 14(1):33-86.
19. Lee, K. P. 1989. Lung response to particulates. In Encyclopedia of environmental control Technology, ed. P. N. Cheremisinoff, vol. 2, pp. 835-882. Houston, TX: Gulf.
20. Lee, K. P., and Gilles, P. J. 1986. Pulmonary response and intrapulmonary lipids in rats exposed to bismuth orthovanadate (BOV) dust inhalation. Environ. Res. 40:115-135.
21. Lee, K. P., Barras, C. E., Griffith, F. D., Waritz, R. S., and Lapin, C. A. 1981. Comparative pulmonary response to inhaled inorganic fibers with asbestos and fiberglass. Environ. Res. 24:167-191.
22. Lee, K. P., Kelly, D. P., and Kennedy, G. L., Jr. 1983. Pulmonary response to inhaled Kevlar aramid synthetic fibers in rats. Toxicol. Appl. Pharmacol. 71:242-253.
23. Lee, K. P., Trochimowicz, H. J., and Reinhardt, C. F. 1985. Pulmonary response of rats exposed to titanium dioxide (TiO2) by inhalation for two years. Toxicol. Appl. Pharmacol. 79:179-192.
24. Lee, K. P., Kelly, D. P., Schneider, P. W., and Trochimowicz, H. J. 1986. Inhalation toxicity study on rats exposed to titanium tetrachloride atmospheric hydrolysis products for two years. Toxicol. Appl. Pharmacol. 93:30-45.
25. Lee, K. P., Kelly, D. P., O'Neal, F. O., Stadler, J. C., and Kennedy, G., Jr. 1988a. Lung response to ultrafine Kevlar aramid synthetic fibers following 2-year inhalation exposure in rats. Fundam. Appl. Toxicol. 11:1-20.
26. Lee, K. P., Ulrich, C. E., Geil, R. G., and Trochimowicz, J. H. 1988b. Effects of inhaled chromium dioxide dust on rats exposed for two years. Fundam. Appl. Toxicol. 10:124-145.
27. Mast, R. W., McConnell, E. E., Anderson, R., Chevalier, J., Kotin, P., Bernstein, D. M., Thevenaz, P., Glass, L. R., Miiller, W. C., and Hesterberg, T. W. 1995a. Studies on the chronic toxicity (inalation) of four types of refractory ceramic fiber in male Fischer 344 rats. Inhal. Toxicol. 7:425-467.
28. Mast, R. W., McConnell, E. E., Hesterberg, T. W., Chevalier, J., Kotin, P., Thevenaz, P., Bernstein, D. M., Glass, L. R., Miiller, W. C., and Anderson, R. 1995b. Multiple-dose chronic inhalation toxicity study of size-serrated kaolin refractory ceramic fiber in male Fischer 344 rats. Inhal. Toxicol. 7:469-502.
29. Martin, J. C., Daniel, H., and Bouffant, L. 1977. Short and long-term experimental study of the toxicity of coal mine dust and some of its constituents. In Inhaled particles, ed. W. H. Walton, vol. IV, part 1, pp. 361-372. Oxford: Pergamon.
30. Maxim, L. D., Mast, R. W., Utell, M. J., Yu, C. P., Boymel, P. M., Zoitos, B. K., and Cason, J. E. 1999. Hazard assessment and risk analysis of two new synthetic vitreous fibers. Regul. Toxicol. Pharmacol. 30:54-74.
31. McConnell, E. E. 1995. Advantages and limitations of in vivo screening tests. Ann. Occup. Hyg. 39:727-735.
32. McConnell, E. E., Wagner, J. C., Skidmore, J. W., and Moore, J. A. 1984. A comparative study of the fibrogenic and carcinogenic effects of UICC Canadian chrysotile B asbestos and glass microfibre (JM 100). In Biological effects of man-made mineral fibres, pp. 234-252. Geneva: World Health Organization.
33. McConnell, E. E., Kamstrup, O., Musselman, R., Hesterberg, T. W., Chevalier, J., Miiller, W. C., and Thevenaz, P. 1994. Chronic inhalation study of size-separated rock and slag wool insulation fibers in Fischer 344/N rats. Inhal. Toxicol. 6:571-614.
34. McConnell, E. E., Mast, R. W., Hesterberg, T. W., Chevalier, J., Kotin, P., Bernstein, D. M., Thevenaz, P., Glass, L. R., and Anderson, R. 1995. Chronic inhalation toxicity of a kaolin-based refractory ceramic fiber in Syrian golden hamsters. Inhal. Toxicol. 7:503-532.
35. Nettesheim, P., and Schreiber, H. 1975. Advance in experimental lung cancer research, pp. 604-691. New York: Springer-Verlag.
36. Pott, F., Schlipkoter, H. W., Ziem, U., Spumy, K., and Huth, F. 1984. New results form implantation experiments with mineral fibres. In Biological effects of man-made mineral fibres, vol. 2, pp. 286-302. Copenhagen: World Health Organization.
37. Richter, C. B. 1970. Application of infectious agents to the study of lung cancer: Studies on the etiology and morphogenesis of meta-plastic lung lesions in mice. In Morphology of experimental respiratory carcinogenesis. Proceedings of a biological division, eds. P. Nettesheim, M. G. Hanna, Jr., and J. W. Deatherage, Jr., pp. 365-381. Oak Ridge National Laboratory Conference, Gatlinburg, TN, 13-16 May.
38. Stanton, M. F., and Wrench, C. 1972. Mechanism of mesothelioma induction with asbestos and fibrous glass. J. Natl. Cancer Inst. 48:797-821.
39. Stanton, M. F., Layard, M., Tergeris, A., Miller, E., May M., and Kent, E. 1977. Carcinogenicity of fibrous glass: Pleural response in the rats in relation to fiber dimension. J. Natl. Cancer Inst. 58:587-603.
40. Taniguchi, M., Tanaka, A., Urata, K., and Lee, K. P. 2000. Workplace environment and health hazard evaluation of potassium octatitanate fiber (PTF) production workers. AIHCE 2000. The premier occupational and environmental health and safety conference and exposition. Abstracts, no. 394, p. 80. 20-25 May. Orlando, FL.
41. Vosame, A. I. 1979. Carcinogenicity studies of estonian oil shale soots. Environ. Health Perspect. 30:173-176.
42. Wehner, A. P., Dagle, G. E., Clark, M. L., and Buschbom, R. I. 1986. Lung changes in rats following inhalation exposure to volcanic ash for two years. Environ. Res. 40:499-517.
43. Wheeler, C. S. 1990. Exposure to man-made mineral fibers: A summary of current animal data. Toxicol. Ind. Health 6:293-307.