Hypertension and Insulin Resistance Are Not Directly Related in Obese Dogs

Hypertension

Volumn 43, Issue 5, 2004, Pages 1011-1016

  Rocchini, Albert P ^a,b   Yang, John Q ^a   Gokee, Amy ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Hypertension; Insulin resistance; Obesity; Sympathetic nervous system

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; ATENOLOL; BETA ADRENERGIC RECEPTOR; CLONIDINE; FUROSEMIDE; I KAPPA B KINASE; PRAZOSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOG; DRUG MEGADOSE; ENZYME INHIBITION; FEMALE; HYPERINSULINEMIA; HYPERTENSION; INSULIN RESISTANCE; LIPID DIET; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SODIUM RESTRICTION;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ASPIRIN; ATENOLOL; BLOOD GLUCOSE; CLONIDINE; DIET, SODIUM-RESTRICTED; DIETARY FATS; DOGS; FEMALE; FUROSEMIDE; HEMODYNAMIC PROCESSES; HYPERTENSION; I-KAPPA B KINASE; INSULIN; INSULIN RESISTANCE; MALE; MODELS, ANIMAL; MODELS, BIOLOGICAL; OBESITY; PRAZOSIN; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; SYMPATHETIC NERVOUS SYSTEM;

EID: 2342511613     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000123073.48855.e9     Document Type: Article

References (39)

1. Rocchini AP, Marker P, Cervenka T. Time course of insulin resistance associated with feeding dogs a high fat diet. Am J Physiol. 1997;272: E147-E154.
2. Rocchini AP, Moorehead CS, DeRemer S, Bondie D. Pathogenesis of weight-related changes in pressure in the dog. Hypertension. 1989;13:922-928.
3. Rocchini AP, Mao HZ, Baba K, Marker P, Rocchini AJ. Clonidine prevents insulin resistance and hypertension in obese dogs. Hypertension. 1999;33:548-553.
4. Rocchini AP, Key J, Bondie D, Chico R, Moorehead C, Katch V, Martin M. The effect of weight loss on the sensitivity of blood pressure to sodium in obese adolescents. N Engl J Med. 1989;321:580-585.
5. Krieger DR, Landsberg L. Mechanism in obesity-related hypertension: role of insulin and catecholamines. Am J Hypertens. 1988;1:84-90.
6. Pollare T, Lithell H, Berne C. Insulin resistance is a characteristic feature of primary hypertension independent of obesity. Metabolism. 1990;39:167-174.
7. Shen DC, Shieh SM, Fuh MM, Wu DA, Chen YD, Reaven GM. Resistance to insulin-simulated-glucose uptake in patients with hypertension. J Clin Endocrinol Metab. 1988;66:580-583.
8. Ferrannini E, Haffner SM, Stern MP. Essential hypertension: an insulin-resistance state. J Cardiovasc Pharmacol. 1990;15:S18-S25.
9. Hall JE, Brands MW, Kivlighn SD, Mizelle HL, Hidebrandt DA, Gaillard CA. Chronic hyperinsulinemia and blood pressure: interaction with catecholamines? Hypertension. 1990;15:519-527.
10. Sowers JB, Whitfield LA, Catania RA, Stern N, Tuck ML, Domfeld L, Maxwell M. Role of the sympathetic nervous system in blood pressure maintenance in obesity. J Clin Endocrinol Metab. 1982;54:1181-1186.
11. Hall JE, Van Vliet BN, Garrity CA, Connell RD, Brands MW. Role of increased adrenergic activity in obesity-induced hypertension. Circulation. 1992;86(suppl I):1-541.
12. Young JB, Saville ME, Rothwell NJ, Stock MJ, Landsberg L. Effect of diet and cold exposure on norepinephrine turnover in brown adipose tissue in the rat. J Clin Invest. 1982;69:1061-1071.
13. Schwartz JH, Young JB, Landsberg L. Effect of diet fat on sympathetic nervous system activity in the rat. J Clin Invest. 1983;72:361-370.
14. Kuo JJ, Barrett-Jones O, Hall JE. Chronic cardiovascular and renal actions of leptin during hyperinsulinemia. Am J Physiol Regul Integr Comp Physiol 2003;284:R1037-R1042.
15. Diebert DC, DeFronzo RA. Epinephrine-induced insulin resistance in man. J Clin Invest. 1980;65:717-721.
16. Jamerson KA, Julius A, Gudbrandsson T, Andersson O, Brant DO. Reflex sympathetic activation induces acute insulin resistance in the human forearm. Hypertension. 1993;21:618-623.
17. Rosen P, Ohly P, Gleichmann H. Experimental benefit of moxonidine on glucose metabolism and insulin secretion in the fructose-fed rat. J Hypertens. 1997;15:S31-S38.
18. Ernsberger P, Friedman JE, Kooletsky RJ. The II-imidazoline receptor: from binding site to therapeutic target in cardiovascular disease. J Hypertens. 1997;15:S9-S23.
19. Kim JK, Kim Y, Fillmore JJ, Chen Y, Moore I, Lee J, Yuan M, Li ZW, Karin M, Perret P, Shoelson SE, Shulman GI. Prevention of fat-induced insulin resistance by salicylate. J Clin Invest 2001;108:437-446.
20. Kassab S, Kato T, Wilkins FC, Chen R, Hall JE, Granger JP. Renal denervation attenuates the sodium retention and hypertension associated with obesity. Hypertension. 1995;25:893-897.
21. Feldman RD, Schmidt ND. Moderate dietary salt restriction increases vascular and systemic insulin resistance. Am J Hypertens. 1999;12:643-647.
22. Egan BM, Stephiakowski K, Goodfriend TL. Renin and aldosterone are higher and the hyperinsulinemic effect of salt restriction greater in subjects with risk factors clustering. Am J Hypertens. 1994;7:866-893.
23. Woford MR, Anderson DC, Brown CA, Jones DW, Miller ME, Hall JE. Antihypertensive effect of α- and β-adrenergic blockade in obese and lean hypertensive subjects. Am J Hypertens. 2001;14:694-698.
24. Antic V, Kiener-Belforti F, Tempini A, Vliet V, Montani JP. Role of the sympathetic nervous system during the development of obesity-induced hypertension in rabbits. Am J Hypertens. 2000;13:556-559.
25. 2-adrenoceptor activation. Br J Pharmacol. 2001;134:957-968.
26. 2-Adrenoceptor function in arterial hypertension associated with obesity in dogs fed a high fat diet. J Hypertens. 2002;20:957-964.
27. 1-adrenoceptor subtypes. Am J Hypertens. 2000;13:529-534.
28. 2-adrenergic vasorelaxation by a pertussis toxin mechanism. Hypertension. 1997;30:1128-1134.
29. Steinberg HO, Baron AD. Vascular function, insulin resistance and fatty acids. Diabetologia. 2002;45:623-634.
30. Baron AD, Laakso M, Brechtel G, Edelman SV. Mechanism of insulin resistance in insulin-dependent diabetes mellitus: a major role for reduced skeletal muscle blood flow. J Clin Endocrinol Metab. 1991;73:637-643.
31. Hall JE. Renal and cardiovascular mechanisms of hypertension in obesity. Hypertension. 1994;23:381-394.
32. Luft FC. G-proteins and insulin signaling. J Mol Med. 1997;75:233-235.
33. Rizzo MA, Romero G. The role of G proteins in insulin signaling. J Basic Clin Physiol Pharmacol. 1998;9:167-195.
34. i2 enhances insulin signaling via suppression of protein-tyrosine phosphatase 1B. J Biol Chem. 2001;276:39705-39712.
35. Swislocki ALM, Vestal RE, Reaven GM, Hoffman BB. Acute metabolic effects of clonidine and adenosine in man. Horm Metab Res. 1993;25:90-95.
36. Barbe P, Galitzky J, Riviere D, Senard JM, Lanfontan M, Garrigues M, Berlan M. Effects of physiological and pharmacological variation of sympathetic nervous system activity on plasma non-esterified fatty acid concentrations in man. Br J Pharmacol. 1993;36:25-30.
37. Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1963;1:785-789.
38. Griffin ME, Marcucci MJ, Cline GW, Bell K, Barucci N, Lee D, Goodyear LJ, Kraegen EW, White MF, Shulman GI. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C-θ and alterations in the insulin signaling cascade. Diabetes. 1999;48:1270-1274.
39. Itani SI, Ruderman NB, Schmieder F, Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C and IKB-α. Diabetes. 2002;51:2005-20011.