Hepatitis B core antigen in liver tissue from HBs-positive, HBe-negative patients

Hepato-Gastroenterology

Volumn 51, Issue 57, 2004, Pages 709-712

  Karpinska, Ewa ^a,b   Wawrzynowicz Syczewska, Marta ^a   Chosia, Maria ^a   Jurczyk, Krzysztof ^a   Urbanowicz, Waldemar ^a   Boron Kaczmarska, Anna ^a  

^a POMERANIAN MEDICAL UNIVERSITY   (Poland)

^b Department of Infectious Diseases ^*  (Poland)

Author keywords

Chronic hepatitis B; HBV; Hepatitis B core antigen; Hepatitis B e antigen

Indexed keywords

AMINOTRANSFERASE; HEPATITIS B ANTIGEN; VIRUS DNA;

ADOLESCENT; ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CHEMICAL ANALYSIS; CHRONIC LIVER DISEASE; CONTROLLED STUDY; CYTOPLASM; DNA DETERMINATION; DNA HYBRIDIZATION; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER; LIVER BIOPSY; LIVER CELL NUCLEUS; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SERODIAGNOSIS; STATISTICAL SIGNIFICANCE;

ADOLESCENT; ADULT; AGED; DNA, VIRAL; FEMALE; HEPATITIS B CORE ANTIGENS; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HUMANS; LIVER; MALE; MIDDLE AGED;

EID: 2342507114     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Lee WM: Hepatitis B virus infection. N Engl J Med 1997; 337:1733-1745.
2. Lok A: Chronic hepatitis B. N Engl J Med 2002; 346:1683-1684.
3. Borg F, Kate FJ, Cuypers HT, Leentvaar A, Oosting J, Werthaim-van Dillen PM, Honkoop P, Rasch MC, Man RA, Hattum J, Chamuleau RA, Reesink HW, Jones EA: Relation between laboratory test results and histological hepatitis activity in individuals positive for hepatitis B surface antigen and antibodies to hepatitis B e antigen. Lancet 1998; 351:1914-1918.
4. Ruiz-Moreno M, Otero M, Millan A, Castillo I, Cabrerizo M, Jimenez FJ, Oliva H, Ramony Cajd S, Careno V: Clinical and histological outcome after Hepatitis B e antigen to antibody seroconversion in children with chronic hepatitis B. Hepatology 1999; 29:572-575.
5. Cha H, Hui Y, Leung N, Ching J, Chan F, Sung J: Risk factors for active liver disease in HBeAg-negative chronic hepatitis B Virus-infected patients. Am J Gastroenterol 2000; 95:3547-3561.
6. Funk ML, Rosenberg D, Lok ASF: World-wide epidemiology of HBeAg-negative chronic hepatitis B and associated precore and core promoter variants. J Viral Hepatitis 2002; 9:52-61.
7. Chan H, Tsang S, Liew Ch, Tse Ch, Wong M, Ching J, Leung N, Tam J, Sung J: Viral genotype and hepatitis B virus DNA levels are correlated with histological liver damage in HBeAg negative chronic hepatitis B virus infection. Am J Gastroenterology 2002; 97:406-412.
8. Lindh M, Savage K, Rees J, Garwood L, Horal P, Norkrans G, Dhillon AP: HBeAg immunostaining of liver tissue in various stages of chronic hepatitis B. Liver 1999; 19:294-298.
9. Hsu HC, Su IJ, Lai MY, Chen DS, Chang H, Chuang SM, Sung JL: Biologic and prognostic significance of hepatocyte hepatitis B core antigen expressions in the natural course of chronic hepatitis B virus infection. J Hepatol 1987; 5:45-50.
10. Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, Kieman TW, Wollman J: Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981; 1:431-435.
11. Perillo RP, Brunt EM: Hepatic histologic and immunohistochemical changes of hepatitis B e antigen and hepatitis B surface antigen. Ann Intern Med. 1991; 115:113-115.
12. Borg F, Kate FJ, Cuypers HT, Leentvaar A, Oosting J, Werthaim-van Dillen PM, Honkoop P, Rasch MC, Man RA, Hattum J, Chamuleau RA, Tytgat GNJ, Jones EA: A survey of liver pathology in needle biopsies from HBsAg and anti-HBe positive individuals. J Clin Pathol 2000; 53:541-548.
13. Martinot-Peignoux M, Boyer N, Colombat M, Akremi R, Pham B, Ollivier S, Castelnau C, Valla D, Degott C, Marcellin P: Serum hepatitis B virus DNA levels and liver histology in inactive HBsAg carries. J Hepatol 2002; 36:543-546.
14. Shamra RR, Dhiman RK, Chawla Y, Vasistha RK: Immunochistochemistry for core and surface antigens in chonic hepatitis. Trop Gastroenterol 2002; 23:16-19.
15. Chu CM, Yeh CT, Sheen IS: Subcellular localisation of hepatitis B core antigen in relation to hepatocyte regeneration in chronic hepatitis B. Gastroenterology 1995; 109:1926-1932.
16. Yeh CT, Wong SW, Fung YK, Ou IH: Cell cycle regulation of nuclear localization of hepatitis B virus core protein. Proc Natl Acad Sci USA 1993; 90:6459-6463.
17. Chu CM, Liaw YF: Natural history of chronic hepatitis B virus infection: an immunopathological study. J Gastroenterol Hepatol 1997; 12(9-10):218-222.
18. Hadziyannis SJ, Vassilopoulos: Immunopathogenesis of hepatitis B e antigen negative chronic hepatitis B infection. Antiviral Research 2001; 52:91-98.
19. Chu CM, Yeh CT, Chien RN: The degrees of hepatocyte nuclear but not cytoplasmic expression of hepatitis B core antigen reflect the level of viral replication in chronic hepatitis B virus infection. J Clin Microbiol 1997; 35:102-105.