A novel pacemaker mechanism drives gastrointestinal rhythmicity

News in Physiological Sciences

Volumn 15, Issue 6, 2000, Pages 291-298

  Sanders, Kenton M ^a   Ördög, Tamás ^a   Koh, Sang Don ^a   Ward, Sean M ^a  

^a UNIVERSITY OF NEVADA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034549386     PISSN: 08861714     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiologyonline.2000.15.6.291     Document Type: Article

References (15)

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2. Cajal SR. Histologie du système nerveux de l'homme et des vertébrés. Paris: Maloine, 1911, vol. 2, p. 891-942.
3. Dickens EJ, Hirst GDS, and Tomita T. Identification of rhythmically active cells in guinea-pig stomach. J Physiol (Lond) 514: 515-531, 1999.
4. Horowitz BM, Ward SM, and Sanders KM. Cellular and molecular basis for electrical rhythmicity in gastrointestinal muscles. Annu Rev Physiol 61: 19-43, 1999.
5. Koh SD, Sanders KM, and Ward SM. Spontaneous electrical rhythmicity in cultured interstitial cells of Cajal from the murine small intestine. J Physiol (Lond) 513: 203-213, 1998.
6. Langton P, Ward SM, Carl A, Norell MA, and Sanders KM. Spontaneous electrical activity of interstitial cells of Cajal isolated from canine proximal colon. Proc Natl Acad Sci USA 86: 7280-7284, 1989.
7. Liu LW, Thuneberg L, and Huizinga JD. Cyclopiazonic acid, inhibiting the endoplasmic reticulum calcium pump, reduces the canine colonic pacemaker frequency. J Pharmacol Exp Ther 275: 1058-1068, 1995.
8. Prosser CL and Mangel AW. Mechanisms of spike and slow wave pacemaker activity in smooth muscle cells. In: Cellular Pacemakers, edited by Carpenter D. New York: John Wiley & Sons, 1982, vol. 1, p. 273-301.
9. Sanders KM. A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract. Gastroenterology 111: 492-515, 1996.
10. Sanders KM, Ördög T, Koh SD, Torihashi S, and Ward SM. Development and plasticity of interstitial cells of Cajal. Neurogastroenterol Motil 11, 311-338, 1999.
11. Thomsen L, Robinson TL, Lee JC, Farraway LA, Hughes MJ, Andrews DW, and Huizinga JD. Interstitial cells of Cajal generate a rhythmic pacemaker current. Nat Med 4: 848-851, 1998.
12. Tomita T. Electrical activity (spikes, and slow waves) in gastrointestinal smooth muscle. In: Smooth Muscle: An Assessment of Current Knowledge, edited by Bulbring E, Brading AF, Jones AW, and Tomita T. Austin, TX: University of Texas, 1981, p. 127-156.
13. Torihashi S, Nishi K, Tokutomi Y, Nishi T, Ward SM, and Sanders KM. Blockade of Kit signaling induces transdifferentiation of interstitial cells of Cajal to a smooth muscle phenotype. Gastroenterology 117: 140-148, 1999.
14. Ward SM, Beckett EAH, Wang XY, Baker F, Khoyi M, and Sanders KM. Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons. J Neurosci 20: 1393-1403, 2000.
15. Ward SM, Ördög T, Koh SD, Baker SA, Jun YT, Amberg G, Monaghan K, Sanders KM. Pacemaking in interstitial cells of Cajal depends upon calcium handling by endoplasmic reticulum and mitochondria. J Physiol (Lond) 527: 149-162, 2000.