CXCR4 but not CXCR3 expression correlates with lymphocyte counts in B-cell chronic lymphocytic leukemia

Annals of Hematology

Volumn 83, Issue 5, 2004, Pages 326-327

  Dao Ung, Lan Phuong ^a   Sluyter, Ronald ^a   Fuller, Stephen J ^a   Taper, John ^a   Wiley, James S ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CD38 ANTIGEN; CD5 ANTIGEN; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR4; MONOCLONAL ANTIBODY;

ADULT; AGED; ANTIGEN EXPRESSION; B CELL LEUKEMIA; BLOOD ANALYSIS; CANCER GRADING; CANCER STAGING; CHRONIC LYMPHATIC LEUKEMIA; COMPUTER PROGRAM; DENSITY GRADIENT CENTRIFUGATION; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOPHENOTYPING; LETTER; LYMPHOCYTE COUNT; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANK SUM TEST;

AGED; AGED, 80 AND OVER; FEMALE; HUMANS; LEUKEMIA, B-CELL, CHRONIC; LEUKEMIA, LYMPHOCYTIC, CHRONIC; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; RECEPTORS, CHEMOKINE; RECEPTORS, CXCR4;

EID: 2342483697     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-004-0846-y     Document Type: Letter

References (6)

1. Barretina J, Junca J, Llano A, Gutierrez A, Hores A, Blanco J, Clotet B, Este JA (2003) CXCR4 and SDF-1 expression in B-cell chronic lymphocytic: leukemia and stage of the disease. Ann Hematol 82:500-505
2. Wiley JS, Dao-Ung LP, Gu BJ, Sluyter R, Shemon AN, Li C, Taper J, Gallo J, Manoharan A (2002) A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: a molecular study. Lancet 359:1114-1119
3. Burger JA, Burger M, Kipps TJ (1999) Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. Blood 94:3658-3667
4. Ishibe N, Albitar M, Jilani IB, Goldin LR, Marti GE, Caporaso NE (2002) CXCR4 expression is associated with survival in familial chronic lymphocytic leukemia, but CD38 expression is not. Blood 100:1100-1101
5. Trentin L, Agostini C, Facco M, Piazza F, Perin A, Siviero M, Gurrieri C, Galvan S, Adami F, Zambello R, Semenzato G (1999) The chemokine receptor CXCR3 is expressed on malignant B cells and mediates chemotaxis. J Clin Invest 104:115-121
6. Jones D, Benjamin RJ, Shahsafaei A, Dorfman DM (2000) The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia. Blood 95:627-632