Low Expression of Human Epithelial Sodium Channel in Airway Epithelium of Preterm Infants with Respiratory Distress

Pediatrics

Volumn 113, Issue 5 I, 2004, Pages 1267-1272

  Helve, Otto ^a,d   Pitkanen, Olli M ^a   Andersson, Sture ^a   O'Brodovich, Hugh ^b,c   Kirjavainen, Turkka ^a   Otulakowski, Gail ^c  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b UNIVERSITY OF TORONTO   (Canada)

^c HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Epithelium; Glucocorticoid; Ion transport; Lung liquid; Respiratory distress syndrome

Indexed keywords

BETAMETHASONE; CYTOKERATIN 18; DEXAMETHASONE; MESSENGER RNA; PORACTANT; SODIUM CHANNEL;

ALPHA EPITHELIAL SODIUM CHANNEL; ARTICLE; ASSISTED VENTILATION; BETA EPITHELIAL SODIUM CHANNEL; CONTROLLED STUDY; DIAGNOSTIC KIT; DOSE RESPONSE; EPITHELIAL SODIUM CHANNEL; FEMALE; GAMMA EPITHELIAL SODIUM CHANNEL; GENE EXPRESSION; GESTATIONAL AGE; HUMAN; IN SITU HYBRIDIZATION; ION TRANSPORT; KNOCKOUT MOUSE; LUNG ALVEOLUS OXYGEN TENSION; LUNG DEVELOPMENT; LUNG FLUID; MALE; NEONATAL RESPIRATORY DISTRESS SYNDROME; NEWBORN; PATHOGENESIS; PREMATURITY; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; RESPIRATORY FAILURE;

ANTI-INFLAMMATORY AGENTS; DEXAMETHASONE; EPITHELIAL SODIUM CHANNEL; FEMALE; GLUCOCORTICOIDS; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; MALE; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, NEWBORN; RESPIRATORY MUCOSA; RNA, MESSENGER; SODIUM CHANNELS;

EID: 2342451924     PISSN: 00314005     EISSN: None     Source Type: Journal    
DOI: 10.1542/peds.113.5.1267     Document Type: Article

References (45)

1. Strang LB. Fetal lung liquid: secretion and reabsorption. Physiol Rev. 1991;71:991-1016
2. Pitkanen OM, O'Brodovich HM. Significance of ion transport during lung development and in respiratory disease of the newborn. Ann Med. 1998;30:134-142
3. O'Brodovich H. Epithelial ion transport in the fetal and perinatal lung. Am J Physiol. 1991;261(suppl):C555-C564
4. Olver RE, Strang LB. Ion fluxes across the pulmonary epithelium and the secretion of lung liquid in the foetal lamb. J Physiol. 1974;241:327-357
5. Brown MJ, Olver RE, Ramsden CA, Strang LB, Walters DV. Effects of adrenaline and of spontaneous labour on the secretion and absorption of lung liquid in the fetal lamb. J Physiol. 1983;344:137-152
6. Pitkarten O, Transwell AK, Downey G, O'Brodovich H. Increased Po2 alters the bioelectric properties of fetal distal lung epithelium. Am J Physiol. 1996;270(suppl):L1060-L1066
7. Bland RD, Nielson DW. Developmental changes in lung epithelial ion transport and liquid movement. Annu Rev Physiol. 1992;54:373-394
8. Barker PM, Gowen CW, Lawson EE, Knowles MR. Decreased sodium ion absorption across nasal epithelium of very premature infants with respiratory distress syndrome. J Pediatr. 1997;130:373-377
9. Canessa CM, Schild L, Buell G, et al. Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature. 1994;367: 463-467
10. O'Brodovich H, Hannam V, Seear M, Mullen JB. Amiloride impairs lung water clearance in newborn guinea pigs. J Appl Physiol. 1990;68: 1758-1762
11. Hummler E, Barker P, Gatzy J, et al. Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nat Genet. 1996;12:325-328
12. Venkatesh VC, Katzberg HD. Glucocorticoid regulation of epithelial sodium channel genes in human fetal lung. Am J Physiol. 1997; 273(suppl):L227-L233
13. Sayegh R, Auerbach SD, Li X, et al. Glucocorticoid induction of epithelial sodium channel expression in lung and renal epithelia occurs via trans-activation of a hormone response element in the 5′-flanking region of the human epithelial sodium channel alpha subunit gene. J Biol Chem. 1999;274:12431-12437
14. Thomas CP, Auerbach SD, Zhang C, Stokes JB. The structure of the rat amiloride-sensitive epithelial sodium channel gamma subunit gene and functional analysis of its promoter. Gene. 1999;228:111-122
15. Lazrak A, Samanta A, Venetsanou K, Barbry P, Matalon S. Modification of biophysical properties of lung epithelial Na(+) channels by dexamethasone. Am J Physiol Cell Physiol. 2000;279:C762-C770
16. Pitkanen OM, Smith D, O'Brodovich H, Otulakowski G. Expression of alpha-, beta-, and gamma-hENaC mRNA in the human nasal, bronchial, and distal lung epithelium. Am J Respir Crit Care Med. 2001;163:273-276
17. Knowles M, Gatzy J, Boucher R. Increased bioelectric potential difference across respiratory epithelia in cystic fibrosis. N Engl J Med. 1981; 305:1489-1495
18. Jorissen M, Bertrand B, Eloy P. Ciliary dyskinesia in the nose and paranasal sinuses. Acta Otorhinolaryngol Belg. 1997;51:353-366
19. Knowles MR, Carson JL, Collier AM, Gatzy JT, Boucher RC. Measurements of nasal transepithelial electric potential differences in normal human subjects in vivo. Am Rev Respir Dis. 1981;124:484-490
20. Otulakowski G, Flueckiger-Staub S, Ellis L, et al. Relation between alpha, beta, and gamma human amiloride-sensitive epithelial Na+ channel mRNA levels and nasal epithelial potential difference in healthy men. Am J Respir Crit Care Med. 1998;158:1213-1220
21. Avery M, Mead J. Surface properties in relation to atelectasis and hyaline membrane disease. Am J Dis Child. 1959;97:517-523
22. Jobe AH. Pulmonary surfactant therapy. N Engl J Med. 1993;328:861-868
23. O'Brodovich HM. Immature epithelial Na+ channel expression is one of the pathogenetic mechanisms leading to human neonatal respiratory distress syndrome. Proc Assoc Am Physicians. 1996;108:345-355
24. DeSa DJ. Pulmonary fluid content in infants with respiratory distress. J Pathol. 1969;97:469-478
25. Tchepichev S, Ueda J, Canessa C, Rossier BC, O'Brodovich H. Lung epithelial Na channel subunits are differentially regulated during development and by steroids. Am J Physiol. 1995;269(suppl):C805-C812
26. O'Brodovich H, Canessa C, Ueda J, Rafii B, Rossier BC, Edelson J. Expression of the epithelial Na+ channel in the developing rat lung. Am J Physiol. 1993;265(suppl):C491-C496
27. Dagenais A, Kothary R, Berthiaume Y. The alpha subunit of the epithelial sodium channel in the mouse: developmental regulation of its expression. Pediatr Res. 1997;42:327-334
28. McDonald FJ, Yang B, Hrstka RF, et al. Disruption of the beta subunit of the epithelial Na+ channel in mice: hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype. Proc Natl Acad Sci U S A. 1999;96:1727-1731
29. Bonny O, Rossier BC. Disturbances of Na/K balance: pseudohypoaldosteronism revisited. J Am Soc Nephrol. 2002;13:2399-2414
30. Bonny O, Chraibi A, Loffing J, et al. Functional expression of a pseudohypoaldosteronism type I mutated epithelial Na+ channel lacking the pore-forming region of its alpha subunit. J Clin Invest. 1999;104: 967-974
31. Kerem E, Bistritzer T, Hanukoglu A, et al. Pulmonary epithelial sodium-channel dysfunction and excess airway liquid in pseudohypoaldosteronism. N Engl J Med. 1999;341:156-162
32. Thomas CP, Zhou J, Liu KZ, Mick VE, MacLaughlin E, Knowles M. Systemic pseudohypoaldosteronism from deletion of the promoter region of the human beta epithelial na(+) channel subunit. Am J Respir Cell Mol Biol. 2002;27:314-319
33. McNicholas CM, Canessa CM. Diversity of channels generated by different combinations of epithelial sodium channel subunits. J Gen Physiol. 1997;109:681-692
34. Konstas AA, Korbmacher C. The gamma-subunit of ENaC is more important for channel surface expression than the beta-subunit. Am J Physiol Cell Physiol. 2003;284:C447-C456
35. Smith DE, Otulakowski G, Yeger H, Post M, Cutz E, O'Brodovich HM. Epithelial Na(+) channel (ENaC) expression in the developing normal and abnormal human perinatal lung. Am J Respir Crit Care Med. 2000; 161(suppl):1322-1331
36. Gowen CW Jr, Lawson EE, Gingras J, Boucher RC, Gatzy JT, Knowles MR. Electrical potential difference and ion transport across nasal epithelium of term neonates: correlation with mode of delivery, transient tachypnea of the newborn, and respiratory rate. J Pediatr. 1988; 113(suppl):121-127
37. Kassovska-Bratinova S, Vannam V, Freywald T, Otulakowski G, O'Brodovich H. Absence of detectable amiloride-sensitive ion transport in murine tracheal epithelia may result from lack of beta-ENaC mRNA expression. Am J Respir Crit Care Med. 2000;161:A234
38. Firsov D, Gautschi I, Merillat AM, Rossier BC, Schild L. The heterotetrameric architecture of the epithelial sodium channel (ENaC). EMBO J. 1998;17:344-352
39. Wright LL, Horbar JD, Gunkel H, et al. Evidence from multicenter networks on the current use and effectiveness of antenatal corticosteroids in low birth weight infants. Am J Obstet Gynecol. 1995;173:263-269
40. Gladstone IM, Ehrenkranz RA, Jacobs HC. Pulmonary function tests and fluid balance in neonates with chronic lung disease during dexamethasone treatment. Pediatrics. 1989;84:1072-1076
41. Bancalari E. Corticosteroids and neonatal chronic lung disease. Eur J Pediatr. 1998;157(suppl 1):S31-S37
42. Folkesson HG, Norlin A, Wang Y, Abedinpour P, Matthay MA. Dexamethasone and thyroid hormone pretreatment upregulate alveolar epithelial fluid clearance in adult rats. J Appl Physiol. 2000;88:416-424
43. Talbot CL, Bosworth DG, Briley EL, et al. Quantitation and localization of ENaC subunit expression in fetal, newborn, and adult mouse lung. Am J Respir Cell Mol Biol. 1999;20:398-406
44. Rafii B, Tanswell AK, Pitkanen O, O'Brodovich H. Induction of epithelial sodium channel (ENaC) expression and sodium transport in distal lung epithelia by oxygen. Curr Top Membr. 1999;47:239-244
45. Minakata Y, Suzuki S, Grygorczyk C, Dagenais A, Berthiaume Y. Impact of beta-adrenergic agonist on Na+ channel and Na+-K+-ATPase expression in alveolar type II cells. Am J Physiol. 1998;275(suppl): L414-L422