Zebrafish pit1 mutants lack three pituitary cell types and develop severe dwarfism

Molecular Endocrinology

Volumn 18, Issue 5, 2004, Pages 1196-1209

  Nica, Gabriela ^a   Herzog, Wiebke ^a   Sonntag, Carmen ^a   Hammerschmidt, Matthias ^a  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; ETHYLNITROSOUREA; FISH PROTEIN; GROWTH HORMONE; INTERMEDIN; PROLACTIN; PROOPIOMELANOCORTIN; THYROTROPIN; TRANSCRIPTION FACTOR PIT 1;

ADENOHYPOPHYSIS; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL TYPE; CONTROLLED STUDY; ECTOPIC ORGAN; EMBRYO; FISH GENETICS; GENE EXPRESSION; GENE MUTATION; GENETIC ANALYSIS; GONADOTROPIN SECRETING CELL; HYPOPHYSIS CELL; LARVAL STAGE; MOLECULAR CLONING; MOUSE; MUTANT; NONHUMAN; ORGANOGENESIS; PITUITARY DWARFISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; ZEBRA FISH;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; DNA-BINDING PROTEINS; DWARFISM; EMBRYO, NONMAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC TECHNIQUES; HOMEODOMAIN PROTEINS; MUTATION; PITUITARY GLAND, ANTERIOR; TRANSCRIPTION FACTOR PIT-1; TRANSCRIPTION FACTORS; ZEBRAFISH;

ANIMALIA; DANIO RERIO; MAMMALIA; VERTEBRATA;

EID: 2342449383     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2003-0377     Document Type: Article

References (49)

1. Burrows HL, Douglas KR, Seasholtz AF, Camper SA 1999 Genealogy of the anterior pituitary gland: tracing a family tree. Trends Endocrinol Metab 10:343-352
2. Dasen JS, Rosenfeld MG 1999 Combinatorial codes in signaling and synergy: lessons from pituitary development. Curr Opin Gen Dev 9:566-574
3. Dasen JS, Rosenfeld MG 1999 Signaling mechanisms in pituitary morphogenesis and cell fate determination. Curr Opin Cell Biol 11:669-677
4. Kioussi C, Carrière C, Rosenfeld MG 1999 A model for the development of the hypothalamic-pituitary axis: transcribing the hypophysis. Mech Dev 81:23-35
5. Sheng HZ, Westphal H 1999 Early steps in pituitary organogenesis. Trends Genet 15:236-240
6. Burgess R, Lunyak V, Rosenfeld MG 2002 Signaling and transcriptional control of pituitary development. Curr Opin Genet Dev 12:534-539
7. Scully KM, Rosenfeld MG 2002 Pituitary development: regulatory codes in mammalian organogenesis. Science 295:2231-2235
8. Zhao L, Bakke M, Krimkevich Y, Cushman LJ, Parlow AF, Camper SA, Parker KL 2001 Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function. Development 128:147-154
9. Lamolet B, Pulichino A-M, Lamonerie T, Gauthier Y, Brue T, Enjalbert A, Drouin J 2001 A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins. Cell 104:849-859
10. Liu J, Lin C, Gleiberman A, Ohgi KA, Herman MA, Huang H, Tsai MJ, Rosenfeld MG 2001 Tbx19, a tissue-selective regulator of POMC gene expression. Proc Natl Acad Sci USA 98:8674-8679
11. Pulichino A-M, Vallette-Kasic S, Tsai JP-Y, Couture C, Gauthier Y, Drouin J 2003 Tpit determines alternate fates during pituitary cell differentiation. Genes Dev 17: 738-747
12. Bousquet C, Zatelli MC, Melmed S 2000 Direct regulation of pituitary proopiomelanocortin by STAT3 provides a novel mechanism for immuno- neuroendocrine interfacing. J Clin Invest 106:1417-1425
13. Bodner M, Castrillo J-L, Theill LE, Deerinck T, Ellisman M, Karin M 1988 The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. Cell 50: 267-275
14. Ingraham HA, Chen R, Mangalam HJ, Elsholtz HP, Flynn SE, Lin CR, Simmons DM, Swanson LW, Rosenfeld MG 1988 A tissue-specific transcription factor containing a homeodomain specifies pituitary phenotype. Cell 50: 519-529
15. Lin S-C, Li S, Drolet DW, Rosenfeld MG 1994 Pituitary ontogeny of the Snell dwarf mouse reveals Pit-1-independent and Pit-1-dependent origins of the thyrotrope. Development 120:515-522
16. Li S, Crenshaw III EB, Rawson EJ, Simmons DM, Swanson LW, Rosenfeld MG 1990 Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene Pit-1. Nature 347:528-533
17. Tatsumi K-i, Miyai K, Notomi T, Kaibe K, Amino N, Mizuno Y, Kohno H 1992 Cretinism with combined hormone deficiency caused by a mutation in the PIT1 gene. Nat Genet 1:56-58
18. Pfäffle RW, DiMattia GE, Parks JS, Brown MR, Wit JM, Jansen M, Van der Nat H, Van den Brande JL, Rosenfeld MG, Ingraham HA 1992 Mutation of the Pou-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia. Science 257:1118-1121
19. Radovick S, Nations M, Du Y, Berg LA, Weintraub B, Wondisford FE 1992 A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency. Science 257:1115-1118
20. Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG 1999 Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types. Cell 97:587-598
21. Gordon DF, Lewis SR, Haugen BR, James RA, McDermott MT, Wood WM, Ridgway EC 1997 Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin β-subunit promoter. J Biol Chem 272: 24339-24347
22. Scully KM, Jabobson EM, Jepsen K, Lunyak V, Viadiu H, Carrière C, Rose DW, Hooshmand F, Aggarwal AK, Rosenfeld MG 2000 Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification. Science 290:1127-1131
23. Chen RP, Ingraham HA, Treacy MN, Albert VR, Wilson L, Rosenfeld MG 1990 Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements. Nature 346:583-586
24. McCormick A, Brady H, Theil LE, Karin M 1990 Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues. Nature 345: 829-832
25. Rhodes SJ, Chen R, DiMattia GE, Scully KM, Kalla KA, Lin S-C, Yu VC, Rosenfeld MG 1993 A tissue specific enhancer confers Pit-1 dependent morphogen inducibility and autoregulation of pit-1 gene. Genes Dev 7:913-932
26. DiMattia GE, Rhodes SJ, Krones A, Carriere C, O'Connell S, Kalla KA, Arias C, Sawchenko PE, Rosenfeld MG 1997 The Pit-1 gene is regulated by distinct early and late pituitary-specific enhancers. Dev Biol 182:180-190
27. Lin SC, Lin CR, Gukovsky I, Lusis AJ, Sawchenko PE, Rosenfeld MG 1993 Molecular basis of the little mouse phenotype and implications for cell type-specific growth. Nature 364:208213.
28. Glasgow E, Karavanov AA, Dawid IB 1997 Neuronal and neuroendocrine expression of lim3, a LIM class homeobox gene, is altered in mutant zebrafish with axial signaling defects. Dev Biol 192:405-419
29. Herzog W, Zeng X, Lele Z, Sonntag C, Ting J-W, Chang C-Y, Hammerschmidt M 2003 Adenohypophysis formation in the zebrafish and its dependence on sonic hedgehog. Dev Biol 254:36-49
30. Liu N-A, Huang H, Yang Z, Herzog W, Hammerschmidt M, Lin S, Melmed S 2003 Pituitary corticotroph ontogeny and regulation in transgenic zebrafish. Mol Endocrinol 17:959-966
31. Nasevicius A, Ekker SC 2000 Effective targeted gene 'knockdown' in zebrafish. Nat Genet 26:216-220
32. Herzog W, Sonntag C, Walderich B, Odenthal J, Maischein H-M, Hammerschmidt M 2004 Genetic analysis of adenohypophysis formation in zebrafish. Mol Endocrinol 18:1185-1195
33. Snell GD 1929 A new mendellan recessive character of the house mouse. Proc Natl Acad Sci USA 15:733-734
34. Camper SA, Saunder TL, Katz RW, Reeves RH 1990 The Pit-1 transcription factor gene is a candidate for the murine snell dwarf mutation. Genomics 8:586-590
35. Streisinger G, Walker C, Dower N, Knauber D, Singer F 1981 Production of clones of homozygous diploid zebrafish, Brachydanio rerio. Nature 291:293-296
36. Treier M, Gleiberman AS, O'Connell SM, Szeto DP, McMahon JA, McMahon AP, Rosenfeld MG 1998 Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev 12:1691-1704
37. Bach I, Rhodes SJ, Pearse RV, Heinzel T, Gloss B, Scully KM, Sawchenko PE, Rosenfeld MG 1995 P-LIM, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1. Proc Natl Acad Sci USA 92:2720-2724
38. Kelly PA, Djiane J, Postel-Vinay MC, Edery M 1991 The prolactin/growth hormone receptor family. Endocr Rev 12:235-251
39. Childs GV, Unabia G, Wu P 2000 Differential expression of growth hormone messenger ribonucleic acid by somatotropes and gonadotropes in male and cycling female rats. Endocrinology 141:1560-1570
40. Childs GV 2000 Growth hormone cells as co-gonadotropes: partners in the regulation of the reproductive system. Trends Endocrinol Metab 11:168-175
41. Childs GV 2002 Development of gonadotropes may involve cyclic transdifferentiation of growth hormone cells. Arch Physiol Biochem 110:42-49
42. Vidal S, Horvath E, Kovacs K, Loloyd RV, Smyth HS 2001 Reversible transdifferentiation: interconversion of somatotrophs and lactotrophs in pituitary hyperplasia. Mod Pathol 14:20-28
43. Vidal S, Horvath E, Kovacs K, Cohen SM, Lloyd RV, Scheithauer BW 2000 Transdifferentiation of somatotrophs to thyrotrophs in the pituitary of patients with protracted primary hypothyroidism. Virchows Arch 436: 43-51
44. Geisler R, Rauch G-J, Baier H, van Bebber F, Broß L, Davis RW, Dekens M, Finger K, Fricke C, Gates MA, Geiger H, Geiger-Rudolph S, Gilmour D, Glaser S, Gnügge L, Habeck H, Hingst K, Holley S, Keenan J, Kim A, Knaut H, Lashkari D, Maderspacher F, Martyn U, Neuhauss S, Neumann C, Nicolson T, Pelegri F, Ray R, Rick, J, Roehl H, Roeser T, Schauerte HE, Schier AF, Schönberger U, Schönthaler H-B, Schulte-Merker S, Seydler C, Talbot WS, Weiler C, Nüsslein-Volhard C, Haffter P 1999 A radiation hybrid map of the zebrafish genome. Nat Genet 23:86-89
45. Geisler R 2002 Mapping and cloning. In: Nüsslein-Volhard C, Dahm R, eds. Zebrafish: a practical approach, vol 261. Oxford, UK: Oxford University Press; 175-212
46. Knapik EW, Goodman A, Ekker M, Chevrette M, Delgado J, Neuhauss S, Shimoda N, Driever W, Fishman MC, Jacob HJ 1998 A microsatellite genetic linkage map for zebrafish (Danio rerio). Nat Genet 18:338-343
47. Hammerschmidt M, Blader P, Strähle U 1999 Strategies to perturb zebrafish development. In: Detrich HW, Westerfield M, Zon LI, eds. Methods in cell biology. Vol 59. San Diego: Academic Press; 87-115
48. Hammerschmidt M, Serbedzija GN, McMahon AP 1996 Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor. Genes Dev 10:2452-2461
49. Cole LK, Ross LS 2001 Apoptosis in the developing zebrafish embryo. Dev Biol 240:123-142