Hepcidin: What every gastroenterologist should know

Gut

Volumn 53, Issue 5, 2004, Pages 624-627

  Walker, A P ^a,c   Partridge, J ^a   Srai, S K ^b   Dooley, J S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c Royal Free Campus   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEPCIDIN; PEPTIDE HORMONE;

AMINO ACID SEQUENCE; ANEMIA; CYTOKINE PRODUCTION; HEMOCHROMATOSIS; HUMAN; IMMUNOHISTOCHEMISTRY; IRON OVERLOAD; KNOCKOUT MOUSE; NONHUMAN; NOTE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION;

ANEMIA; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; HEMOCHROMATOSIS; HUMANS; IRON OVERLOAD; MICE; RATS;

EID: 2342436307     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2003.030304     Document Type: Note

References (28)

1. MacDermott RP, Greenberger NJ. Evidence for a humoral factor influencing iron absorption. Gastroenterology 1969;57:117-25.
2. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003;102:783-8.
3. Krause A, Neitz S, Magert HJ, et al. LEAP-1, a novel highly disulfide-bonded peptide, exhibits antimicrobial activity. FEBS Lett 2000;480:147-50.
4. Park CH, Valore EV, Waring AJ, et al. Hepcidin, a urinary antimicrobial peptide synthesised in the liver. J Biol Chem 2001;276:7806-10.
5. Pigeon C, Ilyin G, Courselaud B, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001;276:7811-19.
6. Nicolas G, Bennoun M, Devaux I, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 2001;98:8780-5.
7. Nicolas G, Bennoun M, Porteu A, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA 2002;99:4596-601.
8. Weiss G. Pathogenesis and treatment of anaemia of chronic disease. Blood Rev 2002;16:87-96.
9. Weinstein DA, Roy CN, Fleming MD, et al. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 2002;100:3776-81.
10. Nemeth E, Valore EV, Territo M, et al. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003;101:2461-3.
11. Nicolas G, Viatte L, Bennoun M, et al. Hepcidin, a new iron regulatory peptide. Blood Cell Mol Dis 2002;29:327-35.
12. Courselaud B, Pigeon C, Inoue Y, et al. C/EBP alpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. J Biol Chem 2002;277:41163-70.
13. Roetto A, Papanikolaou G, Politou M, et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 2003;33:21-2.
14. Kelly AL, Rhodes DA, Roland JM, et al. Hereditary juvenile haemochromatosis: a genetically heterogeneous life-threatening iron-storage disease. QJM 1998;91:607-18.
15. Roetto A, Totaro A, Cazzola M, et al. Juvenile hemochromatosis locus maps to chromosome 1q. Am J Hum Genet 1999;64:1388-93.
16. Merryweather-Clarke AT, Cadet E, Bomford A, et al. Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis. Hum Mol Genet 2003;12:2241-7.
17. The UK Haemochromatosis Consortium. A simple genetic test identifies 90% of UK patients with haemochromatosis. Gut 1997;41:841-4.
18. Bridle KR, Frazer DM, Wilkins SJ, et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 2003;361:669-73.
19. Ahmad KA, Ahmann JR, Migas MC, et al. Decreased liver hepcidin expression in the Hfe knockout mouse. Blood Cells Mol Dis 2002;29:361-6.
20. Muckenthaler M, Roy CN, Custodio AO, et al. Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet 2003;34:102-7.
21. Frazer DM, Wilkins SJ, Becker EM, et al. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 2002;123:835-44.
22. Turlin B, Deugnier Y. Evaluation and interpretation of iron in the liver. Semin Diagn Pathol 1998;15:237-45.
23. Dallalio G, Fleury T, Means RT. Serum hepcidin in clinical specimens. Br J Haematol 2003;122:996-1000.
24. Kulaksiz H, Gehrke SG, Janetzko A, et al. Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia. Gut 2003;53:735-43.
25. Kluver E, Schulz A, Forssmann WG, et al. Chemical synthesis of beta-defensins and LEAP-1/hepcidin. J Peptide Res 2002;59:241-8.
26. Hunter HN, Fultan DB, Ganz T, et al. The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. J Biol Chem 2002;277:37597-603.
27. Wilkins MR, Lindskog I, Gasteiger, E, et al. Detailed peptide characterisation using PEPTIDEMASS - a World-Wide Web accessible tool. Electrophoresis 1997;18:403-8.
28. Lee P, Gelbart T, West C, et al. A study of genes that may modulate the expression of hereditary hemochromatosis: transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (IRP)-1 and -2, and hepcidin. Blood Cells Mol Dis 2001;27:783-802.