Low serum β-carotene reflects immune activation in patients with coronary artery disease

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 13, Issue 3, 2003, Pages 120-125

  Jonasson, L ^a   Wikby, A ^b   Olsson, A G ^c  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^b JÖNKÖPING UNIVERSITY   (Sweden)

^c LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Antioxidant; C reactive protein; Coronary artery disease; Immune system; T lymphocytes; carotene

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; BETA CAROTENE; C REACTIVE PROTEIN; INTERLEUKIN 2 RECEPTOR; LYCOPENE;

ADULT; ANGIOGRAPHY; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FLOW CYTOMETRY; HUMAN; IMMUNE RESPONSE; INFLAMMATION; MALE; QUANTITATIVE ANALYSIS; STABLE ANGINA PECTORIS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANGINA;

EID: 2342423591     PISSN: 09394753     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-4753(03)80170-9     Document Type: Article

References (35)

1. Ross R (1999) Atherosclerosis: an inflammatory disease. N Engl J Med 340: 115-126
2. Neri Serneri GG, Prisco D, Martini F, Gori AM, Brunelli T, Poggesi L, Rostagno C, Gensini GF, Abbate R (1997) Acute T cell activation is detectable in unstable angina. Circulation 95: 1806-1812
3. Mazzone A, De Servi S, Vezzoli M, Fossati G, Mazzucchelli I, Gritti D, Ottini E, Mussini A, Specchia G (1999) Plasma levels of interleukin 2,6,10 and phenotype characterization of circulating T lymphocytes in ischemic heart disease. Atherosclerosis 145: 369-374
4. Jonasson L, Linderfalk C, Olsson J, Wikby A, Olsson AG (2002) Systemic T cell activation in stable angina pectoris. Am J Cardiol 89: 754-756
5. Riemersmaa RA, Wood DA, Macyntire CC, Elton RA, Gey KF, Oliver MF (1991) Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene. Lancet 337: 1-5
6. Gey KF, Stähelin HB, Eichholzer M (1993) Poor plasma status of carotene and vitamin C is associated with higher mortality from ischemic heart disease and stroke: Basel Prospective Study. Clin Invest 71: 3-6
7. Ford ES, Giles WH (2000) Serum vitamins, carotenoids, and angina pectoris: findings from the National Health and Nutrition Examination Survey III. Ann Epidemiol 10: 106-116
8. D'Odorico A, Martines D, Kiechl S, Egger G, Oberhollenzer F, Bonvicini P, Sturniolo GC, Naccarato R, Willeit J (2000) High plasma levels of alpha- and beta-carotene are associated with a lower risk of atherosclerosis: results from the Bruneck study. Atherosclerosis 153: 231-239
9. Hughes DA (1999) Effects of carotenoids on human immune function. Proc Nutr Soc 58: 713-718
10. Serafini M (2000) Dietary vitamin E and T cell-mediated function in the elderly: effectiveness and mechanism of action. Int J Dev Neurosci 18: 401-410
11. Jyonouchi H, Zhang L, Gross M, Tomita Y (1994) Immunomodulating actions of carotenoids: enhancement of in vivo and in vitro antibody production to T-dependent antigens. Nutr Cancer 21: 47-58
12. Kazi N, Radvany R, Oldham T, Keshavarzian A, Frommel TO, Libertin C, Mobarhan S (1997) Immunomodulatory effect of β-carotene on T lymphocyte subsets in patients with resected colonic polyps and cancer. Nutr Cancer 28: 140-145
13. De la Fuente M, Victor VM (2000) Anti-oxidants as modulators of immune function. Immunol Cell Biol 78: 49-54
14. Boosalis MG, Snowdon DA, Tully CL, Gross MD (1996) Acute phase response and plasma carotenoid concentrations in older women: findings from the Nun Study. Nutrition 12: 475-478
15. Kritchevsky SB, Bush AJ, Pahor M, Gross MD (2000) Serum carotenoids and markers of inflammation in nonsmokers. Am J Epidemiol 152: 1065-1071
16. Erlinger TP, Guallar E, Miller ER, Stolzenberg-Solomon R, Appel LJ (2001) Relationship between systemic markers of inflammation and serum beta-carotene levels. Arch Intern Med 161: 1903-1908
17. Schäfer Elinder L, Walldius G (1992) Simultaneous measurement of serum probucol and lipid-soluble anti-oxidants. J Lipid Res 33: 131-137
18. Kristenson M, Zieden B, Kucinskiene Z, Schäfer Elinder L, Bergdahl B, Elwing B, Abaravicius A, Razinkoviene L, Calkauskas H, Olsson AG (1997) Antioxidant state and mortality from coronary heart disease in Lithuanian and Swedish men: concomitant cross sectional study of men aged 50. BMJ 314: 629-633
19. Esterbauer H, Puhl H, Dieber-Rotheneder M, Waeg G, Rabi H (1991) Effects of antioxidants on oxidative modification of LDL. Ann Med 23: 573-581
20. Watzl B, Bub A, Brandstetter BR, Rechkemmer G (1999) Modulation of human T-lymphocyte functions by the consumption of carotenoid-rich vegetables. Br J Nutr 82: 383-389
21. Chew BP, Park JS, Wong TS, Kim HW, Weng BB, Byrne KM, Hayel MG, Reinhart GA (2000) Dietary beta-carotene stimulates cell-mediated and humoral immune response in dogs. J Nutr 130: 1910-1913
22. Talwar D, Ha TK, Scott HR, Cooney J, Fell GS, O'Reilly DS, Lean ME, McMillan DC (1997) Effect of inflammation on measures of antioxidant status in patients with non-small cell lung cancer. Am J Clin Nutr 66: 1283-1285
23. Chang CY, Lai YC, Cheng TJ, Lau MT, Hu ML (1998) Plasma levels of antioxidant vitamins, selenium, total sulfhydril groups and oxidative products in ischemic-stroke patients as compared to matched controls in Taiwan. Free Radic Res 28: 15-24
24. Cutts JL, Bankhurst AD (1989) Suppression of lymphoid cell function in vitro by inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by lovastatin. J Immunopharmacol 11: 863-869
25. Jialal I, Stein D, Balis D, Grundy SM, Adams-Huet B, Devaraj S (2001) Effect of hydroxymethyl glutaryl coenzyme A reductase inhibitor therapy on high sensitive C-reactive protein levels. Circulation 103: 1933-1935
26. Chew BP, Wong TS, Michael JJ, Standaert FE, Heirman LR (1991) Subcellular distribution of beta-carotene, retinol, and alpha-tocopherol in porcine lymphocytes after a single injection of beta-carotene. J Anim Sci 69: 4892-4897
27. Chew BP, Wong TS, Michael JJ (1993) Uptake of orally administered beta-carotene by blood plasma, leukocytes and lipoproteins in calves. J Anim Sci 71: 730-739
28. Torbergsen AC, Collins AR (2000) Recovery of human lymphocytes from oxidative DNA damage; the apparent enhancement of DNA repair by carotenoids is probably simply an antioxidant effect. Eur J Nutr 39: 80-85
29. Konopacka M, Rzeszowska-Wolny J (2001) Antioxidant vitamins C, E and beta-carotene reduce DNA damage before as well as after gamma-ray irradiation of human lymphocytes in vitro. Mutat Res 491: 1-7
30. Santos MS, Leka L, Ribaya-Mercado JD, Russell RM, Meydani M, Hennekens CH, Gaziano JM, Meydani SN (1997) Short- and long-term beta-carotene supplementation do not influence T cell-mediated immunity in healthy elderly persons. Am J Clin Nutr 66: 917-924
31. Gossage C, Deyhim M, Moser-Veillon PB, Douglas LW, Kramer TR (2000) Effect of beta-carotene supplementation and lactation on carotenoid metabolism and mitogenic T lymphocyte proliferation. Am J Clin Nutr 71: 950-955
32. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S, Hammar S (1996) Effects of combinations of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 334: 1150-1155
33. Virtamo J, Rapola JM, Ripatti S, Heinonen OP, Taylor PR, Albanes D, Huttunen JK (1998) Effect of vitamin E and beta carotene on the incidence of primary nonfatal myocardial infarction and fatal coronary heart disease. Arch Intern Med 158: 668-675
34. Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR, Belanger C, LaMotte F, Gaziano JM, Ridker PM, Willett W, Peto R (1996) Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 334: 1145-1149
35. Heart Protection Study Collaborative Group (2002) MRC/BHF Heart Protection Study on antioxidant vitamin supplementation in 20 536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360: 23-33