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Volumn 6, Issue 8, 2005, Pages 831-837

VX-950 Vertex/Mitsubishi

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CILUPREVIR; MERIMEPODIB; PEGINTERFERON; PLACEBO; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; VX 950;

EID: 23344440213     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (19)

References (47)
  • 1
    • 33644486968 scopus 로고    scopus 로고
    • Vertex and Eli Lilly form strategic alliance to develop drugs to treat hepatitis C infection
    • 250154 Vertex Pharmaceuticals Inc PRESS RELEASE June 13
    • 250154 Vertex and Eli Lilly form strategic alliance to develop drugs to treat hepatitis C infection. Vertex Pharmaceuticals Inc PRESS RELEASE 1997 June 13
    • (1997)
  • 2
    • 0033920304 scopus 로고    scopus 로고
    • Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3′ nontranslated region are essential for virus replication in vivo
    • 356013
    • 356013 Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3′ nontranslated region are essential for virus replication in vivo. Kolykhalov AA, Mihalik K, Feinstone SM, Rice CM J VIROL 2000 74 4 2046-2051
    • (2000) J. Virol. , vol.74 , Issue.4 , pp. 2046-2051
    • Kolykhalov, A.A.1    Mihalik, K.2    Feinstone, S.M.3    Rice, C.M.4
  • 3
    • 33644491463 scopus 로고    scopus 로고
    • Lilly and Vertex select HCV candidate for development
    • 435040 Eli Lilly & Co PRESS RELEASE January 07
    • 435040 Lilly and Vertex select HCV candidate for development. Eli Lilly & Co PRESS RELEASE 2002 January 07
    • (2002)
  • 4
    • 33644483261 scopus 로고    scopus 로고
    • Vertex to lead VX-950 development, amends Lilly agreement
    • 475316 Vertex Pharmaceuticals Inc PRESS RELEASE January 02
    • 475316 Vertex to lead VX-950 development, amends Lilly agreement. Vertex Pharmaceuticals Inc PRESS RELEASE 2003 January 02
    • (2003)
  • 5
    • 33644497127 scopus 로고    scopus 로고
    • Solid phase parallel synthesis of α-ketoamide inhibitors of NS3.4A HCV protease
    • 502281 Abs MEDI 97
    • 502281 Solid phase parallel synthesis of α-ketoamide inhibitors of NS3.4A HCV protease. Court JJ, Cottrell KC, Harbeson SL, Pitlik J ACS 2003 226 Abs MEDI 97
    • (2003) ACS , vol.226
    • Court, J.J.1    Cottrell, K.C.2    Harbeson, S.L.3    Pitlik, J.4
  • 9
    • 33644476845 scopus 로고    scopus 로고
    • Vertex's HCV protease inhibitor VX-950 shows preclinical promise
    • 510538 Vertex Pharmaceuticals Inc PRESS RELEASE October 27
    • 510538 Vertex's HCV protease inhibitor VX-950 shows preclinical promise. Vertex Pharmaceuticals Inc PRESS RELEASE 2003 October 27
    • (2003)
  • 10
    • 0036893172 scopus 로고    scopus 로고
    • National Institutes of Health Consensus Development Conference Statement: Management of hepatitis C 2002
    • 511533 (June 10-12, 2002)
    • 511533 National Institutes of Health Consensus Development Conference Statement: Management of hepatitis C 2002 (June 10-12, 2002). GASTROENTEROLOGY 2002 123 6 2082-2099
    • (2002) Gastroenterology , vol.123 , Issue.6 , pp. 2082-2099
  • 11
    • 33644484240 scopus 로고    scopus 로고
    • Future Antivirals - SMi Conference. Latest developments in HIV, Hepatitis, Herpes, Influenza, RSV and SARS, London, UK
    • 513647 IDDB MEETING REPORT November 12-13
    • 513647 Future Antivirals - SMi Conference. Latest developments in HIV, Hepatitis, Herpes, Influenza, RSV and SARS, London, UK. Harrison R IDDB MEETING REPORT 2003 November 12-13
    • (2003)
    • Harrison, R.1
  • 12
    • 33644480463 scopus 로고    scopus 로고
    • 514086 The American Association for the Study of Liver Diseases - 54th Annual Meeting, Boston, MA, USA, 24-28 October 2003. IDDB MEETING REPORT
    • 514086 The American Association for the Study of Liver Diseases - 54th Annual Meeting, Boston, MA, USA, 24-28 October 2003. Susman E IDDB MEETING REPORT 2003
    • (2003)
    • Susman, E.1
  • 13
    • 79953231799 scopus 로고    scopus 로고
    • Vertex Pharmaceuticals reports data on investigational hepatitis C therapies suggesting potential for novel treatment approaches
    • 533196 Vertex Pharmaceuticals Inc PRESS RELEASE April 16
    • 533196 Vertex Pharmaceuticals reports data on investigational hepatitis C therapies suggesting potential for novel treatment approaches. Vertex Pharmaceuticals Inc PRESS RELEASE 2004 April 16
    • (2004)
  • 14
    • 33644494270 scopus 로고    scopus 로고
    • 533720 Protease Inhibitors - ScreenTech World Summit, San Diego, CA, USA, 23-24 March 2004. IDDB MEETING REPORT March 23-24
    • 533720 Protease Inhibitors - ScreenTech World Summit, San Diego, CA, USA, 23-24 March 2004. Stewart K IDDB MEETING REPORT 2004 March 23-24
    • (2004)
    • Stewart, K.1
  • 16
    • 33644492121 scopus 로고    scopus 로고
    • Vertex combines pipeline candidates in HCV studies
    • 536309 Vertex Pharmaceuticals Inc PRESS RELEASE May 04
    • 536309 Vertex combines pipeline candidates in HCV studies. Vertex Pharmaceuticals Inc PRESS RELEASE 2004 May 04
    • (2004)
  • 17
    • 33644482346 scopus 로고    scopus 로고
    • 540281 International Society for Antiviral Research - 17th Annual International Conference on Antiviral Research (Part II), Tucson, AZ, USA, 2-6 May 2004. IDDB MEETING REPORT 02-06 May
    • 540281 International Society for Antiviral Research - 17th Annual International Conference on Antiviral Research (Part II), Tucson, AZ, USA, 2-6 May 2004. Smee D IDDB MEETING REPORT 2004 02-06 May
    • (2004)
    • Smee, D.1
  • 18
    • 33644492478 scopus 로고    scopus 로고
    • Vertex's oral protease inhibitor enters the clinic for HCV
    • 542937 Vertex Pharmaceuticals Inc PRESS RELEASE June 08
    • 542937 Vertex's oral protease inhibitor enters the clinic for HCV. Vertex Pharmaceuticals Inc PRESS RELEASE 2004 June 08
    • (2004)
  • 19
    • 2342420348 scopus 로고    scopus 로고
    • In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: Structural analysis indicates different resistance mechanisms
    • 542949
    • 542949 In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: Structural analysis indicates different resistance mechanisms. Lin C, Lin K, Luong YP, Rao BG, Wei YY, Brennan DL, Fulghum JR, Hsiao HM, Ma S, Maxwell JP, Cottrell KM et al J BIOL CHEM 2004 279 17 17508-17514
    • (2004) J. Biol. Chem. , vol.279 , Issue.17 , pp. 17508-17514
    • Lin, C.1    Lin, K.2    Luong, Y.P.3    Rao, B.G.4    Wei, Y.Y.5    Brennan, D.L.6    Fulghum, J.R.7    Hsiao, H.M.8    Ma, S.9    Maxwell, J.P.10    Cottrell, K.M.11
  • 20
    • 33644484025 scopus 로고    scopus 로고
    • Vertex outlicenses Asian rights to oral HCV drug
    • 544354 Vertex Pharmaceuticals Inc PRESS RELEASE June 14
    • 544354 Vertex outlicenses Asian rights to oral HCV drug. Vertex Pharmaceuticals Inc PRESS RELEASE 2004 June 14
    • (2004)
  • 22
    • 4644221540 scopus 로고    scopus 로고
    • Progress and development of small molecule HCV antivirals
    • 550035
    • 550035 Progress and development of small molecule HCV antivirals. Ni Z-J, Wagman AS CURR OPIN DRUG DISCOVERY DEV 2004 7 4 446-459
    • (2004) Curr. Opin. Drug Discovery Dev. , vol.7 , Issue.4 , pp. 446-459
    • Ni, Z.-J.1    Wagman, A.S.2
  • 23
    • 33644480146 scopus 로고    scopus 로고
    • Vertex Pharmaceuticals reports completion of dosing in the phase Ia clinical study of VX-950, an oral HCV protease inhibitor for the treatment of hepatitis C
    • 557798 Vertex Pharmaceuticals Inc PRESS RELEASE September 07
    • 557798 Vertex Pharmaceuticals reports completion of dosing in the phase Ia clinical study of VX-950, an oral HCV protease inhibitor for the treatment of hepatitis C. Vertex Pharmaceuticals Inc PRESS RELEASE 2004 September 07
    • (2004)
  • 25
    • 33644478083 scopus 로고    scopus 로고
    • Vertex Pharmaceuticals reports positive results from first-in-human study for VX-950, an investigational oral protease inhibitor for the treatment of hepatitis C
    • 567855 Vertex Pharmaceuticals Inc PRESS RELEASE November 01
    • 567855 Vertex Pharmaceuticals reports positive results from first-in-human study for VX-950, an investigational oral protease inhibitor for the treatment of hepatitis C. Vertex Pharmaceuticals Inc PRESS RELEASE 2004 November 01
    • (2004)
  • 26
    • 33644491041 scopus 로고    scopus 로고
    • Vertex Pharmaceuticals announces advancement to phase Ib clinical trial for VX-950, an investigational oral protease inhibitor for the treatment of hepatitis C
    • 569516 Vertex Pharmaceuticals Inc PRESS RELEASE November 08
    • 569516 Vertex Pharmaceuticals announces advancement to phase Ib clinical trial for VX-950, an investigational oral protease inhibitor for the treatment of hepatitis C. Vertex Pharmaceuticals Inc PRESS RELEASE 2004 November 08
    • (2004)
  • 27
    • 36349009983 scopus 로고    scopus 로고
    • Comparison of two anti-HCV clinical candidates, VX-950 and BILN 2061, for potency and resistance in the HCV replicon system and in a novel HCV protease animal model
    • 571269
    • 571269 Comparison of two anti-HCV clinical candidates, VX-950 and BILN 2061, for potency and resistance in the HCV replicon system and in a novel HCV protease animal model. Lin K, Lin C, Kalkeri G, Almquist S, Luong YP, Rao BG, Wei Y, Gates CA, Perni RB, Kwong AD ANTIVIR RES 2004 62 2 A83-A84
    • (2004) Antivir. Res. , vol.62 , Issue.2
    • Lin, K.1    Lin, C.2    Kalkeri, G.3    Almquist, S.4    Luong, Y.P.5    Rao, B.G.6    Wei, Y.7    Gates, C.A.8    Perni, R.B.9    Kwong, A.D.10
  • 28
    • 33644482234 scopus 로고    scopus 로고
    • In vitro combination studies of VX-950 (a HCV protease inhibitor) or VX-497 (an IMPDH inhibitor), two novel anti-HCV clinical candidates, with IFN-α
    • 571270
    • 571270 In vitro combination studies of VX-950 (a HCV protease inhibitor) or VX-497 (an IMPDH inhibitor), two novel anti-HCV clinical candidates, with IFN-α. Lin K, Lin C, Kwong AD ANTIVIR RES 2004 62 2 A52
    • (2004) Antivir. Res. , vol.62 , Issue.2
    • Lin, K.1    Lin, C.2    Kwong, A.D.3
  • 29
    • 33644494269 scopus 로고    scopus 로고
    • VX-950, a novel HCV protease inhibitor, retains potency against BILN-2061 resistant replicon cells: Computational analysis indicates that resistance develops via different mechanisms
    • 571271
    • 571271 VX-950, a novel HCV protease inhibitor, retains potency against BILN-2061 resistant replicon cells: Computational analysis indicates that resistance develops via different mechanisms. Lin C, Lin K, Luong YP, Rao BG, Wei YY, Brennan D, Fulghum J Frantz D, Hsiao HM, Ma S, Maxwell J et al J HEPATOL 2004 40 Suppl 1 21
    • (2004) J. Hepatol. , vol.40 , Issue.SUPPL. 1 , pp. 21
    • Lin, C.1    Lin, K.2    Luong, Y.P.3    Rao, B.G.4    Wei, Y.Y.5    Brennan, D.6    Fulghum, J.7    Frantz, D.8    Hsiao, H.M.9    Ma, S.10    Maxwell, J.11
  • 30
    • 33644494170 scopus 로고    scopus 로고
    • Clearance and rebound kinetics of HCV RNA in replicon cells treated with VX-950, a novel HCV NS34A protease inhibitor, alone or in combination with interferon-α
    • 571272
    • 571272 Clearance and rebound kinetics of HCV RNA in replicon cells treated with VX-950, a novel HCV NS34A protease inhibitor, alone or in combination with interferon-α. Lin K, Perni RB, Kwong AD, Lin C J HEPATOL 2004 40 Suppl 1 11
    • (2004) J. Hepatol. , vol.40 , Issue.SUPPL. 1 , pp. 11
    • Lin, K.1    Perni, R.B.2    Kwong, A.D.3    Lin, C.4
  • 32
    • 33644491158 scopus 로고    scopus 로고
    • Mechanism-based design of synergistic therapeutics for hepatitis C
    • 574833 December 01-02
    • 574833 Mechanism-based design of synergistic therapeutics for hepatitis C. Thomson J SMI CONF - ADV ANTIVIR THER 2004 December 01-02
    • (2004) SMI Conf. - Adv. Antivir. Ther.
    • Thomson, J.1
  • 33
    • 4444243196 scopus 로고    scopus 로고
    • Hepatitis C treatment update
    • 590948
    • 590948 Hepatitis C treatment update. Pearlman BL AM J MED 2004 117 5 344-352
    • (2004) Am. J. Med. , vol.117 , Issue.5 , pp. 344-352
    • Pearlman, B.L.1
  • 34
    • 33644483032 scopus 로고    scopus 로고
    • Vertex Pharmaceuticals reports that VX-950, an investigational oral hepatitis C protease inhibitor, displays potent antiviral activity in early clinical study
    • 600335 Vertex Pharmaceuticals Inc PRESS RELEASE May 10
    • 600335 Vertex Pharmaceuticals reports that VX-950, an investigational oral hepatitis C protease inhibitor, displays potent antiviral activity in early clinical study. Vertex Pharmaceuticals Inc PRESS RELEASE 2005 May 10
    • (2005)
  • 35
    • 23344440820 scopus 로고    scopus 로고
    • Vertex Pharmaceuticals reports that oral hepatitis C protease inhibitor, VX-950, dramatically reduces viral levels in phase Ib clinical study
    • 601958 Vertex Pharmaceuticals Inc PRESS RELEASE May 17
    • 601958 Vertex Pharmaceuticals reports that oral hepatitis C protease inhibitor, VX-950, dramatically reduces viral levels in phase Ib clinical study. Vertex Pharmaceuticals Inc PRESS RELEASE 2005 May 17
    • (2005)
  • 38
    • 0036830454 scopus 로고    scopus 로고
    • Side effects of therapy of hepatitis C and their management
    • 605086
    • 605086 Side effects of therapy of hepatitis C and their management. Fried MW HEPATOLOGY 2002 36 5 Suppl 1 S237-S244
    • (2002) Hepatology , vol.36 , Issue.5 SUPPL. 1
    • Fried, M.W.1
  • 39
    • 9644275435 scopus 로고    scopus 로고
    • Combination of a hepatitis C virus NS3-NS4A protease inhibitor and α interferon synergistically inhibits viral RNA replication and facilitates viral RNA clearance in replicon cells
    • 605507
    • 605507 Combination of a hepatitis C virus NS3-NS4A protease inhibitor and α interferon synergistically inhibits viral RNA replication and facilitates viral RNA clearance in replicon cells. Lin K, Kwong AD, Lin C ANTIMICROB AGENTS CHEMOTHER 2004 48 12 4784-4792
    • (2004) Antimicrob. Agents Chemother. , vol.48 , Issue.12 , pp. 4784-4792
    • Lin, K.1    Kwong, A.D.2    Lin, C.3
  • 44
    • 0024509701 scopus 로고    scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • 606825
    • 606825 Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M SCIENCE 2005 244 4902 359-362
    • (2005) Science , vol.244 , Issue.4902 , pp. 359-362
    • Choo, Q.L.1    Kuo, G.2    Weiner, A.J.3    Overby, L.R.4    Bradley, D.W.5    Houghton, M.6
  • 45
    • 23344445204 scopus 로고    scopus 로고
    • Initial results of a phase 1b, multiple-dose study of VX-950, a hepatitis C virus protease inhibitor
    • 607083 Abs 527
    • 607083 Initial results of a phase 1b, multiple-dose study of VX-950, a hepatitis C virus protease inhibitor. Reesink HW, Zeuzem S, Van Vliet A, McNair L, Purdy S, Chu HM, Jansen PLM GASTROENTEROLOGY 2005 28 4 Suppl 2 Abs 527
    • (2005) Gastroenterology , vol.28 , Issue.4 SUPPL. 2
    • Reesink, H.W.1    Zeuzem, S.2    Van Vliet, A.3    McNair, L.4    Purdy, S.5    Chu, H.M.6    Jansen, P.L.M.7
  • 47
    • 33644493176 scopus 로고    scopus 로고
    • Bear-Biotech-Confab Update
    • 611232 BEAR STEARNS CO INC June 28
    • 611232 Bear-Biotech-Confab Update. Schoenebaum M, Samad A BEAR STEARNS CO INC 2005 June 28
    • (2005)
    • Schoenebaum, M.1    Samad, A.2


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