Identification of sanguinarine as a novel HIV protease inhibitor from high-throughput screening of 2,000 drugs and natural products with a cell-based assay

Letters in Drug Design and Discovery

Volumn 2, Issue 5, 2005, Pages 364-371

  Cheng, Ting Jen ^a   Goodsell, David S ^b   Kan, Chen Chen ^a  

^a KECK GRADUATE INSTITUTE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

E. coli based system; High throughput screening; HIV protease; HIV protease inhibitors; HIV protease precursor; Sanguinarine

Indexed keywords

BETA GALACTOSIDASE; CHELERYTHRINE; INDINAVIR; NATURAL PRODUCT; NELFINAVIR; PROTEINASE; PROTEINASE INHIBITOR; SANGUINARINE; SAQUINAVIR;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS REACTION; CYTOTOXICITY; DRUG IDENTIFICATION; DRUG PROTEIN BINDING; DRUG SPECIFICITY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; HIGH THROUGHPUT SCREENING; IC 50; IN VITRO STUDY; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; STRUCTURE ACTIVITY RELATION;

EID: 23244440510     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/1570180054405811     Document Type: Article

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