Synthesis of labeled oligonucleotides through a new chemically cleavable linker

Tetrahedron Letters

Volumn 46, Issue 36, 2005, Pages 6149-6153

  Mahajan, S ^a   Patnaik, S ^a   Gandhi, R P ^b   Gupta, K C ^a   Kumar, P ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b UNIVERSITY OF DELHI   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYLAMINE; METHANOL; METHYLAMINE; OLIGOMER; OLIGONUCLEOTIDE; PHOSPHORAMIDIC ACID DERIVATIVE; SODIUM CHLORIDE; SODIUM HYDROXIDE;

ARTICLE; DEPROTECTION REACTION; FREEZE DRYING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ROOM TEMPERATURE; SYNTHESIS;

EID: 23244440429     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.06.164     Document Type: Article

References (24)

1. S. Beck, T. O'Keeffe, J.M. Coull, and H. Koster Nucleic Acid Res. 17 1989 5115 5123
2. A. Green, A. Roopra, and M. Vaudin Nucleic Acid Res. 18 1990 6163 6164
3. T. Hultman, S. Stahl, E. Hornes, and M. Uhlen Nucleic Acid Res. 17 1989 4937 4946
4. M.-J. De Vos, A. Cravador, J.-P. Lenders, S. Houard, and A. Bollen Nucleosides Nucleotides 9 1990 259 273
5. M. Bengtstrom, L. Harju, and A.-C. Syvanen Nucleosides Nucleotides 10 1991 507 509
6. A. Reyes-Engel, and J.L. Dieguez-Lucena Nucleic Acid Res. 21 1993 759 760
7. C.M. Niemeyer, T. Sano, C.L. Smith, and C.R. Cantor Nucleic Acid Res. 22 1994 5530 5539
8. K. Misiura, I. Durrant, M.R. Evans, and M.J. Gait Nucleic Acid Res. 18 1990 4345 4354
9. P. Kumar, A.K. Sharma, and K.C. Gupta Nucleosides Nucleotides 15 1996 1263 1273
10. P. Kumar, D. Bhatia, B.S. Garg, and K.C. Gupta Bioorg. Med. Chem. Lett. 4 1994 1761 1766
11. M. Manoharan, G. Inamati, and K.L. Tivel Nucleosides Nucleotides 16 1997 1411 1413
12. U. Pieles, B.S. Sproat, and G.M. Lamm Nucleic Acid Res. 18 1990 4355 4360
13. Z. Zhao, and J. Ackroyd Nucleosides Nucleotides 18 1999 1231 1234
14. M. Shimkus, J. Levy, and T. Herman Proc. Natl. Acad. Sci. U.S.A. 82 1985 2593 2597
15. J. Olejnik, S. Sonar, E. Krzymanska-Olejnik, and K.J. Rothschild Proc. Natl. Acad. Sci. U.S.A. 92 1995 7590 7594
16. J. Olejnik, E. Krzymanska-Olejnik, and K.J. Rothschild Nucleic Acid Res. 24 1996 361 366
17. S. Fang, and D.E. Bergstrom Nucleic Acid Res. 31 2003 708 715
18. S. Fang, and D.E. Bergstrom Bioconjug. Chem. 14 2003 80 85
19. M.P. Reddy, N.B. Hanna, and F. Farooqui Tetrahedron Lett. 35 1994 4311 4314
20. P. Kumar, and K.C. Gupta Nucleic Acid Res. 27 1999 e2
21. D. Wagner, J.P.H. Verheyden, and J.G. Moffatt J. Org. Chem. 39 1974 24 30
22. +).
23. Gene Assembler Plus Manual, Uppsala, Sweden, 1988.
24. Analytical HPLC was performed on an Agilent 1100 series fitted with a diode array detector set at 254 nm using a Hypersil Gold RP-18 column (125 mm × 4 mm). Solvent A = 0.1 M ammonium acetate, pH 7.1 and solvent B = 100% MeCN; Gradient: 0-45% B in 35 min; Flow rate: 1.0 mL/min.