Nω-nitro-L-arginine methyl ester (L-NAME) amplifies the pulmonary hypertensive response to microparticle injections in broilers

Poultry Science

Volumn 84, Issue 7, 2005, Pages 1077-1091

  Wideman, R F ^a   Erf, G F ^a   Chapman, M E ^a  

^a UNIVERSITY OF ARKANSAS   (United States)

Author keywords

Broiler; L NAME; Nitric oxide; Pulmonary hypertension

Indexed keywords

ENZYME INHIBITOR; MICROSPHERE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIOSYNTHESIS; BIRD DISEASE; CHICKEN; DRUG ANTAGONISM; HEART OUTPUT; MALE; METABOLISM; PATHOPHYSIOLOGY; PULMONARY HYPERTENSION; VASOCONSTRICTION;

ANIMALS; CARDIAC OUTPUT; CHICKENS; ENZYME INHIBITORS; HYPERTENSION, PULMONARY; MALE; MICROSPHERES; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POULTRY DISEASES; VASOCONSTRICTION;

EID: 23244432648     PISSN: 00325791     EISSN: None     Source Type: Journal    
DOI: 10.1093/ps/84.7.1077     Document Type: Article

References (72)

1. Burton, R. R., E. L. Besch, and A. H. Smith. 1968. Effect of chronic hypoxia on the pulmonary arterial blood pressure of the chicken. Am. J. Physiol. 214:1438-1442.
2. Burton, R. R., and A. H. Smith. 1967. The effect of polycythemia and chronic hypoxia on heart mass in the chicken. J. Appl. Physiol. 22:782-785.
3. Chang, C. C., C. C. McCormick, A. W. Lin, R. R. Dietert, and Y.-J. Sung. 1996. Inhibition of nitric oxide synthase gene expression in vivo and in vitro by repeated doses of endotoxin. Am. J. Physiol. 271:G539-G548.
4. Chapman, M. E., and R. F. Wideman. 2001. Pulmonary wedge pressures confirm pulmonary hypertension in broilers is initiated by an excessive pulmonary arterial (precapillary) resistance. Poult. Sci. 80:468-473.
5. Chapman, M. E., and R. F. Wideman. 2002. Hemodynamic responses of broiler pulmonary vasculature to intravenously infused serotonin. Poult. Sci. 81:231-238.
6. Chapman, M. E., W. Wang, G. F. Erf, and R. F. Wideman. 2005. Pulmonary hypertensive responses of broilers to bacterial lipopolysaccharide (LPS): Evaluation of LPS source and dose, and impact of pre-existing pulmonary hypertension and cellulose microparticle selection. Poult. Sci. 84:432-441.
7. Cueva, S., H. Sillau, A. Valenzuela, and H. Ploog. 1974. High altitude induced pulmonary hypertension and right ventricular failure in broiler chickens. Res. Vet. Sci. 16:370-374.
8. Dil, N., and M. A. Qureshi. 2002a. Differential expression of inducible nitric oxide synthase is associated with differential toll-like receptor-4 expression in chicken macrophages from different genetic backgrounds. Vet. Immunol. Immunopathol. 84:191-207.
9. Dil, N., and M. A. Qureshi. 2002b. Involvement of LPS-related receptors and nuclear factor kappa-b in differential expression of inducible nitric oxide synthase in chicken macrophages from different genetic backgrounds. Vet. Immunol. Immunopathol. 88:149-161.
10. Fedde, M. R. 1986. Respiration. Pages 191-220 in Avian Physiology. 4th ed. P. J. Sturkie, ed. Springer-Verlag, New York.
11. Fedde, M. R., G. E. Weigle, and R. F. Wideman. 1998. Influence of feed deprivation on ventilation and gas exchange in broilers: Relationship to pulmonary hypertension syndrome. Poult. Sci. 77:1704-1710.
12. Forman, M. F., and R. F. Wideman. 1999. Renal responses of normal and preascitic broilers to systemic hypotension induced by unilateral pulmonary artery occlusion. Poult. Sci. 78:1773-1785.
13. Forman, M. F., and R. F. Wideman. 2001. Furosemide does not facilitate pulmonary vasodilation in broilers during chronic or acute unilateral pulmonary artery occlusion. Poult. Sci. 80:937-943.
14. Gladwin, M. T., J. H. Crawford, and R. P. Patel. 2004. The biochemistry of nitric oxide, nitrite, and hemoglobin: Role in blood flow regulation. Free Radic. Biol. Med. 36:707-717.
15. Grabarevic, Z., M. Tisljar, B. Artukovic, M. Bratulic, P. Dzaja, S. Seiwerth, P. Sikiric, J. Peric, D. Geres, and J. Kos. 1997. The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks. J. Physiol (Paris) 91:139-149.
16. Huchzermeyer, F. W., and A. M. C. DeRuyck. 1986. Pulmonary hypertension syndrome associated with ascites in broilers. Vet. Rec. 119:94-96.
17. Huchzermeyer, F. W., A. M. C. DeRuyck, and H. Van Ark, 1988. Broiler pulmonary hypertension syndrome. III. Commercial broiler strains differ in their susceptibility. Onderstepoort J. Vet. Res. 55:5-9.
18. Hussain, I., and M. A. Qureshi. 1997. Nitric oxide synthase activity and mRNA expression in chicken macrophages. Poult. Sci. 76:1524-1530.
19. Hussain, I., and M. A. Qureshi. 1998. The expression and regulation of inducible nitric oxide synthase gene differ in macrophages from chickens of different genetic background. Vet. Immunol. Immunopathol. 61:317-329.
20. 50 in the chicken. Am. J. Physiol. 250:R260-R266.
21. Jandel Scientific. 1994. SigmaStat Statistical Software User's Manual. Jandel Scientific Software, San Rafael, CA.
22. Julian, R. J. 1989. Lung volume of meat-type chickens. Avian Dis. 33:174-176.
23. Julian, R. J. 1993. Ascites in poultry. Avian Pathol. 22:419-454.
24. Julian, R. J. 2000. Physiological, management and environmental triggers of the ascites syndrome: A review. Avian Pathol. 29:519-527.
25. Julian, R. J., and S. M. Mirsalimi. 1992. Blood oxygen concentration of fast-growing and slow-growing broiler chickens, and chickens with ascites from right ventricular failure. Avian Dis. 36:730-732.
26. Lauer, T., P. Kleinbongard, and M. Kelm. 2002. Indexes of NO bioavailability in human blood. News Physiol. Sci. 17:251-255.
27. Lubritz, D. L., J. L. Smith, and B. N. McPherson. 1995. Heritability of ascites and the ratio of right to total ventricle weight in broiler breeder male lines. Poult. Sci. 74:1237-1241.
28. Martinez-Lemus, L. A., R. K. Hester, E. J. Becker, J. S. Jeffrey, and T. W. Odom. 1999. Pulmonary artery endothelium-dependent vasodilation is impaired in a chicken model of pulmonary hypertension. Am. J. Physiol. 277:R190-197.
29. Martinez-Lemus, L. A., R. K. Hester, E. J. Becker, G. A. Ramirez, and T. W. Odom. 2003. Pulmonary artery vasoactivity in broiler and leghorn chickens: An age profile. Poult. Sci. 82:1957-1964.
30. National Research Council. 1994. Nutrient Requirements of Poultry. 9th rev. ed. National Academy Press, Washington, DC.
31. Odom, T. W., L. A. Martinez-Lemus, R. K. Hester, E. J. Becker, J. S. Jeffrey, G. A. Meininger, and G. A. Ramirez. 2004. In vitro hypoxia differentially affects constriction and relaxation responses of isolated pulmonary arteries from broiler and leghorn chickens. Poult. Sci. 83:835-841.
32. Owen, R. L., R. F. Wideman, G. F. Barbato, B. S. Cowen, B. C. Ford, and A. L. Hattel. 1995. Morphometric and histologic changes in the pulmonary system of broilers raised at simulated high altitude. Avian Pathol. 24:293-302.
33. Peacock, A. J., C. Pickett, K. Morris, and J. T. Reeves. 1989. The relationship between rapid growth and pulmonary hemodynamics in the fast-growing broiler chicken. Am. Rev. Respir. Dis. 139:1524-1530.
34. Peacock, A. J., C. Pickett, K. Morris, and J. T. Reeves. 1990. Spontaneous hypoxaemia and right ventricular hypertrophy in fast growing broiler chickens reared at sea level. Comp. Biochem. Physiol. 97A:537-541.
35. Powell, F. L., R. H. Hastings, and R. W. Mazzone. 1985. Pulmonary vascular resistance during unilateral pulmonary artery occlusion in ducks. Am. J. Physiol. 249:R39-R43.
36. Qureshi, M. A. 2003. Avian macrophage and immune response: An overview. Poult. Sci. 82:691-698.
37. Reeves, J. T., G. Ballam, S. Hofmeister, C. Pickett, K. Morris, and A. Peacock. 1991. Improved arterial oxygenation with feed restriction in rapidly growing broiler chickens. Comp. Biochem. Physiol. 99A:481-485.
38. Roush, W. B., and R. F. Wideman. 2000. Evaluation of growth velocity and acceleration in relation to pulmonary hypertension syndrome. Poult. Sci. 79:180-191.
39. Ruiz-Feria, C. A., K. W. Beers, M. T. Kidd, and R. F. Wideman. 1999. Plasma taurine levels in broilers with pulmonary hypertension syndrome induced by unilateral pulmonary artery occlusion. Poult. Sci. 78:1627-1633.
40. Ruiz-Feria, C. A., M. T. Kidd, and R. F. Wideman. 2001. Plasma levels of arginine, ornithine, and urea and growth performance of broilers fed supplemental L-arginine during cool temperature exposure. Poult. Sci. 80:358-369.
41. Ruiz-Feria, C. A., and R. F. Wideman. 2001. Taurine, cardiopulmonary hemodynamics, and pulmonary hypertension syndrome in broilers. Poult. Sci. 80:1607-1618.
42. Sturkie, P. D. 1986. Heart and circulation: Anatomy, hemodynamics, blood pressure, blood flow. Pages 130-166 in Avian Physiology. 4th ed. P. J. Sturkie, ed. Springer-Verlag, New York.
43. Swenson, M. J. 1993. Physiological properties and cellular and chemical constituents of blood. Pages 22-48 in Dukes' Physiology of Domestic Animals. 11th ed. M. J. Swenson and W. O. Reece, ed. Cornell University Press, Ithaca, NY.
44. Villamor, E., K. Ruijtenbeek, V. Pulgar, J. G. R. De Mey, and C. E. Blanco. 2002. Vascular reactivity in intrapulmonary arteries of chicken embryos during transition to ex ovo life. Am. J. Physiol. 282:R917-R927.
45. Wang, W., G. F. Erf, and R. F. Wideman. 2002a. Pulmonary hypertensive response to endotoxin in cellulose-primed and unprimed broiler chickens. Poult. Sci. 81:1224-1230.
46. Wang, W., G. F. Erf, and R. F. Wideman. 2002b. Effect of cage vs. floor litter environments on the pulmonary hypertensive response to intravenous endotoxin and on blood-gas values in broilers. Poult. Sci. 81:1728-1737.
47. Wang, J., X. Wang, R. Xiang, and W. Sun. 2002c. Effect of L-NAME on pulmonary arterial pressure, plasma nitric oxide and pulmonary hypertension syndrome morbidity in broilers. Br. Poult. Sci. 43:615-620.
48. Wang, W., R. F. Wideman, T. K.Bersi, and G. F. Erf. 2003. Pulmonary and hematological inflammatory responses to intravenous cellulose microparticles in broilers. Poult. Sci. 82:771-780.
49. Weidong, S., W. Xiaolong, W. Jinyong, and J. Ruiping. 2002. Pulmonary arterial pressure and electrocardiograms in broiler chickens infused intravenously with L-NAME, an inhibitor of nitric oxide synthase, or sodium nitroprusside (SNP), a nitric oxide donor. Br. Poult. Sci. 43:306-312.
50. Wideman, R. F. 1999. Cardiac output in four-, five- and six-week-old broilers, and hemodynamic responses to intravenous injections of epinephrine. Poult. Sci. 78:392-403.
51. Wideman, R. F. 2000. Cardio-pulmonary hemodynamics and ascites in broiler chickens. Poult. Avian Biol. Rev. 11:21-43.
52. Wideman, R. F. 2001. Pathophysiology of heart/lung disorders: Pulmonary hypertension syndrome in broiler chickens. World's Poult. Sci. J. 57:289-307.
53. Wideman, R. F., and W. G. Bottje. 1993. Current understanding of the ascites syndrome and future research directions. Pages 1-20 in Nutrition and Technical Symposium Proceedings. Novus International, Inc., St. Louis, MO.
54. Wideman, R. F., and M. E. Chapman. 2004. Nω-Nitro-L-Arginine Methyl Ester (L-NAME) amplifies the pulmonary hypertensive response to endotoxin in broilers. Poult. Sci. 82:485-494.
55. 2) in broilers. Poult. Sci. 84:442-453.
56. Wideman, R. F., M. E. Chapman, C. M. Owens, M. K. Devabhaktuni, L. C. Cavitt, and G. F. Erf. 2003. Broiler survivors of intravenous microparticle injections: Evaluation of growth, livability, meat quality, and arterial blood gas values during a cyclic heat challenge. Poult. Sci. 82:484-495.
57. Wideman, R. F., M. E. Chapman, W. Wang, and G. F. Erf. 2004. Immune modulation of the pulmonary hypertensive response to bacterial lipopolysaccharide (endotoxin) in broilers. Poult. Sci. 83:624-637.
58. Wideman, R. F., and G. F. Erf. 2002. Intravenous microparticle injections trigger pulmonary hypertension in broiler chickens. Poult. Sci. 81:877-886.
59. Wideman, R. F., G. F. Erf, and M. E. Chapman. 2001. Intravenous endotoxin triggers pulmonary vasoconstriction and pulmonary hypertension in broiler chickens. Poult. Sci. 80:647-655.
60. Wideman, R. F., G. F. Erf, M. E. Chapman, W. Wang, N. B. Anthony, and L. Xiaofong. 2002. Intravenous microparticle injections and pulmonary hypertension in broiler chickens: Acute postinjection mortality and ascites susceptibility. Poult. Sci. 81:1203-1217.
61. Wideman, R. F., M. R. Fedde, C. D. Tackett, and G. E. Weigle. 2000. Cardio-pulmonary function in preascitic (hypoxemic) or normal broilers inhaling ambient air or 100% oxygen. Poult. Sci. 79:415-425.
62. Wideman, R. F., M. F. Forman, J. D. Hughes, Y. K. Kirby, N. Marson, and N. B. Anthony. 1998. Flow-dependent pulmonary vasodilation during acute unilateral pulmonary artery occlusion in jungle fowl. Poult. Sci. 77:615-626.
63. Wideman, R. F., and H. French. 1999. Broiler breeder survivors of chronic unilateral pulmonary artery occlusion produce progeny resistant to pulmonary hypertension syndrome (ascites) induced by cool temperatures. Poult. Sci. 78:404-411.
64. Wideman, R. F., and H. French. 2000. Ascites resistance of progeny from broiler breeders selected for two generations using chronic unilateral pulmonary artery occlusion. Poult. Sci. 79:396-401.
65. Wideman, R. F., and Y. K. Kirby. 1995a. A pulmonary artery clamp model for inducing pulmonary hypertension syndrome (ascites) in broilers. Poult. Sci. 74:805-812.
66. Wideman, R. F., and Y. K. Kirby. 1995b. Evidence of a ventilation-perfusion mismatch during acute unilateral pulmonary artery occlusion in broilers. Poult. Sci. 74:1209-1217.
67. Wideman, R. F., Y. K. Kirby, M. Ismail, W. G. Bottje, R. W. Moore, and R. C. Vardeman. 1995. Supplemental L-arginine attenuates pulmonary hypertension syndrome (ascites) in broilers. Poult. Sci. 74:323-330.
68. Wideman, R. F., Y. K. Kirby, R. L. Owen, and H. French. 1997. Chronic unilateral occlusion of an extra-pulmonary primary bronchus induces pulmonary hypertension syndrome (ascites) in male and female broilers. Poult. Sci. 76:400-404.
69. Wideman, R. F., Y. K. Kirby, C. D. Tackett, N. E. Marson, and R. W. McNew. 1996. Cardio-pulmonary function during acute unilateral occlusion of the pulmonary artery in broilers fed diets containing normal or high levels of arginine-HCl. Poult. Sci. 75:1587-1602.
70. Wideman, R. F., P. Maynard, and W. G. Bottje. 1999a. Thromboxane mimics the pulmonary but not systemic vascular responses to bolus HCl injections in broiler chickens. Poult. Sci. 78:714-721.
71. Wideman, R. F., P. Maynard, and W. G. Bottje. 1999b. Venous blood pressure in broilers during acute inhalation of 5% carbon dioxide or unilateral pulmonary artery occlusion. Poult. Sci.78:1443-1451.
72. Wideman, R. F., and C. Tackett. 2000. Cardio-pulmonary function in broilers reared at warm or cold temperatures: Effect of acute inhalation of 100% oxygen. Poult. Sci. 79:257-264.